Peroxidase substrates stimulate the oxidation of hydralazine to metabolites which cause single-strand breaks in DNA

Chemical Research in Toxicology

Volumn 10, Issue 3, 1997, Pages 328-334

  Reilly, Christopher A ^a   Aust, Steven D ^a  

^a UTAH STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPROMAZINE; DRUG METABOLITE; HYDRALAZINE; PEROXIDASE; PHENOL DERIVATIVE; RADICAL; THIORIDAZINE; TRIFLUPROMAZINE;

ABSORPTION SPECTROPHOTOMETRY; AEROBIC METABOLISM; ARTICLE; CANCER; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG METABOLISM; DRUG OXIDATION; LUPUS ERYTHEMATOSUS;

DNA DAMAGE; DNA, SINGLE-STRANDED; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICALS; HORSERADISH PEROXIDASE; HYDRALAZINE; HYDROGEN-ION CONCENTRATION; OXIDATION-REDUCTION; PEROXIDASES; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0030949577     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx960189l     Document Type: Article

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