Properties of multinucleated giant cells in a new in vitro model for human granuloma formation

Journal of Pathology

Volumn 182, Issue 1, 1997, Pages 99-105

  Seitzer, Ulrike ^a   Scheel Toellner, Dagmar ^b   Toellner, Kai Michael ^b   Reiling, Norbert ^a   Haas, Helmut ^a   Galle, Jürgen ^a   Flad, Hans Dieter ^a   Gerdes, Johannes ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

in vitro granuloma; inducible nitric oxide synthase (iNOS); interleukin 1 beta (IL 1 ); interleukin 6 (IL 6); multinucleated giant cell; single cell reverse transcriptase polymerase chain reaction (RT PCR); tumour necrosis factor alpha (TNF )

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; ENZYME SYNTHESIS; GIANT CELL; GRANULOMA; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LARVAL DEVELOPMENT; NIPPOSTRONGYLUS BRASILIENSIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CELL CULTURE TECHNIQUES; CYTOKINES; GIANT CELLS; GRANULOMA; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOPHENOTYPING; MODELS, BIOLOGICAL; NIPPOSTRONGYLUS; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR;

EID: 0030949559     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199705)182:1<99::AID-PATH807>3.0.CO;2-X     Document Type: Article

References (30)

1. Williams GT, Williams WJ. Granulomatous inflammation: a review. J Clin Pathol 1983; 36: 723-733.
2. Warren KS. The secret of the immunopathogenesis of schistosomiasis. In vivo models. Immunol Rev 1982; 61: 189-213.
3. Bentley AG, Philips SM, Kaner RJ, Theodorides VJ, Linette GP, Doughty BL. In vitro delayed hypersensitivity granuloma formation: development of an antigen-coated bead model. J Immunol 1985; 134: 4163-4169.
4. Kasahara K, Kobyashi K, Shikama Y, et al. The role of monokines in granuloma formation in mice: the ability of interleukin 1 and tumor necrosis factor-α to induce lung granulomas. Clin Immunol Immunopathol 1989; 51: 419-425.
5. Möst J, Neumayer HP, Dierich MP. Cytokine-induced generation of multinucleated giant cells in vitro requires interferon-γ and expression of LFA-1. Eur J Immunol 1990; 20: 1661-1667.
6. McNally AK, Anderson JM. Interleukin 4 induces foreign body giant cells from human monocytes/macrophages. Differential lymphokine regulation of monophage fusion leads to morphological variants of multinucleated giant cell. Am J Pathol 1995; 147: 1487-1499.
7. Fais S, Burgio VL, Silvestri M, Capobianchi MR, Pacchiarotti A, Pallone F. Multinucleated giant cell generation induced by Interferon γ. Changes in the expression and distribution of the intercellular adhesion molecule-1 during macrophage fusion and multinucleated giant cell formation. Lab Invest 1994; 71: 737-744.
8. Takashima T, Ohnishi K, Tsuyuguchi I, Kishimoto S. Differential regulation of formation of multinucleated giant cells from concanavalin A-stimulated human blood monocytes by IFN-γ and IL-4. J Immunol 1993; 150: 3002-3010.
9. Enelow RI, Sullivan GW, Carper HT, Mandell GL. Induction of multinucleated giant cell formation from in vitro culture of human monocytes with interleukin-3 and interferon-γ: comparison with other stimulating factors. Am J Respir Cell Mol Biol 1992; 6: 57-62.
10. Kobayashi K, Allred C, Cohen S, Yoshida T. Role of interleukin 1 in experimental pulmonary granuloma in mice. J Immunol 1985; 134: 358-364.
11. Kindler V, Sappino A-P, Grau GE, Piguet P-F, Vassalli P. The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection. Cell 1989; 56: 731-740.
12. Chensue SW, Otterness IG, Higashi GI, Shmyr Forsch C, Kunkel SL. Monokine production by hypersensitivity (Schistosoma mansoni egg) and foreign body (Sephadex bead)-type granuloma macrophages. Evidence for sequential production of IL-I and tumour necrosis factor. J Immunol 1989; 142: 1281-1286.
13. Kreipe H, Radzun HJ, Rudolph P, et al. Multinucleated giant cells generated in vitro. Terminally differentiated macrophages with down-regulated c-fms expression. Am J Pathol 1988; 130: 232-243.
14. Mechtersheimer G, Möller P. Phenotyping of human epithelioid cells, alveolar macrophages, and foamy cells by means of mAb of the myeloid section. In: Knapp W, Dörken B, Gilks WR, et al. eds. Leucocyte Typing IV. White Cell Differentiation Antigens. Oxford: Oxford University Press, 1989; 918-921.
15. Enelow RI, Sullivan GW, Carper HT, Mandell GL. Cytokine-induced human multinucleated giant cells have enhanced candidacidal activity and oxidative capacity compared with macrophages. J Infect Dis 1992; 166: 664-668.
16. Toellner K-M, Scheel-Toellner D, Seitzer U, et al. The use of reverse transcription polymerase chain reaction to analyse large numbers of mRNA-species from a single cell. J Immunol Methods 1996; 191: 71-75.
17. Cordell JL, Fallini B, Erber WN, et al. Immunoenzymatic labelling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase antibodies (APAAP complexes). J Histochem Cytochem 1984; 32: 219-229.
18. Backé E, Schwarting R, Gerdes J, Ernst M, Stein H. Ber-Mac3: new monoclonal antibody that defines human monocyte/macrophage differentiation antigen. J Clin Pathol 1991; 44: 936-945.
19. Herzbeck H, Blum B, Rönspeck W, Brandt E, Ulmer AJ, Flad H-D. Functional and molecular characterization of a monoclonal antibody against the 165-186 peptide of human IL-1β. Scand J Immunol 1989; 30: 549-562.
20. Bringman TS, Aggarwal BB. Monoclonal antibodies to human tumor necrosis factors α and beta: application for affinity purification, immunoassays, and as structural probes. Hybridoma 1987; 6: 489-507.
21. Vincent SR, Kimura H. Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience 1992; 46: 755-784.
22. Bronner-Fraser M. Alterations in neural crest migration by a monoclonal antibody that affects cell adhesion. J Cell Biol 1985; 101: 610-617.
23. Adams DO. The structure of mononuclear phagocytes differentiating in vivo. Am J Pathol 1975; 80: 101-116.
24. Papadimitriou JM, Spector WG. The origin, properties and fate of epithelioid cells. J Pathol 1971; 105: 187-203.
25. Ramaswamy K, De Sanctis GT, Green F, Befus D. Pathology of pulmonary parasitic migration: morphological and bronchoalveolar cellular responses following Nippostrongylus brasiliensis infection in rats. J Parasitol 1991; 77: 302-312.
26. Warren KS. The cell biology of granulomas (aggregates of inflammatory cells) with a note on giant celts. In: The Cell Biology of Inflammation, Amsterdam: Elsevier/North Holland Biomedical Press, 1980: 543-557.
27. Franklin GF, Goghill G, McIntosh L, Cree IA. Monocyte aggregation around agarose beads in collagen gels: a 3-dimensional model of early granuloma formation? J Immunol Methods 1995; 186: 285-291.
28. Shikama Y, Kobayashi K, Kasahara K, et al. Granuloma formation by artificial microparticles in vitro. Am J Pathol 1989; 134: 1189-1199.
29. Hibbs J Jr, Taintor RR, Vavrin Z. Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite. Science 1987; 235: 473-476.
30. Beesley JE. Histochemical methods for detecting nitric oxide synthase. Histochem J 1995; 27: 757-769.