An additional primary proteolytic processing site in merozoite surface protein-1 of Plasmodium berghei

Molecular and Biochemical Parasitology

Volumn 85, Issue 1, 1997, Pages 125-129

  Wiser, Mark F ^a   Toebe, Carole S ^a,b   Jennings, Gregory J ^a,c  

^a TULANE UNIVERSITY   (United States)

^b CITY COLLEGE OF SAN FRANCISCO   (United States)

^c MICHIGAN DEPARTMENT OF COMMUNITY HEALTH   (United States)

Author keywords

malaria; merozoite surface; Plasmodium berghei; proteolytic processing; vaccine

Indexed keywords

MALARIA VACCINE;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; MALARIA; MEROZOITE; NONHUMAN; PLASMODIUM BERGHEI; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING;

AMINO ACID SEQUENCE; ANIMALS; CONSENSUS SEQUENCE; CONSERVED SEQUENCE; MEROZOITE SURFACE PROTEIN 1; MOLECULAR SEQUENCE DATA; PLASMODIUM BERGHEI; PROTEIN PRECURSORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTOZOAN PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY;

EID: 0030949382     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(96)02811-3     Document Type: Article

References (22)

1. Holder, A.A. (1988) The precursor to major merozoite surface antigens: structure and role in immunity. Prog. Allergy 40, 72-97.
2. Cooper, J.A. (1993) Merozoite surface antigen-1 of Plasmodium. Parasitol. Today 9, 50-54.
3. Holder, A.A., Blackman, M.J., Burghaus, P.A., Chappel, J.A., Ling, I.T., McCallum-Deighton, N. and Shai, S. (1992) A malaria merozoite surface protein (MSP-1)-structure, processing and function. Mem. Inst. Oswaldo. Cruz. 87 (Suppl. III), 37-42.
4. r 185000 glycoprotein form the surface of isolated Plasmodium falciparum merozoites form an antigenic complex. Mol. Biochem. Parasitol. 23, 71-84.
5. Blackman, M.J., Whittle, H. and Holder, A.A. (1991) Processing of the Plasmodium falciparum major merozoite surface protein-1: identification of a 33-kilodalton secondary processing product which is shed prior to erythrocyte invasion. Mol. Biochem. Parasitol. 49, 35-44.
6. 33 as a noncovalently associated complex with other fragments of the MSP-1. Mol. Biochem. Parasitol. 50, 307-316.
7. Gerold, P., Schofield, L., Blackman, M.J., Holder, A.A. and Schwarz, R.T. (1996) Structural analysis of the glycosyl-phosphatidylinositol membrane anchor of the merozoite surface proteins-1 and -2 of Plasmodium falciparum. Mol. Biochem. Parasitol. 75, 131-143.
8. Blackman, M.J., Ling, I.T., Nichols, S.C. and Holder, A.A. (1991) Proteolytic processing of the Plasmodium falciparum merozoite surface protein-1 produces a membrane bound fragment containing two epidermal growth factor-like domains. Mol. Biochem. Parasitol. 49, 29-34.
9. Blackman, M.J., Heidrich, H-G, Donachie, S., McBride, J.S. and Holder, A.A. (1990) A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion inhibiting antibodies. J. Exp. Med. 172, 379-382.
10. Lewis, A.P. (1990) Sequence analysis of the gene encoding the precursor to the major merozoite surface antigen of Plasmodium yoelii. Mol. Biochem. Parasitol. 39, 285-288.
11. Deleersnijder, W., Hendrix, D., Bendahman, N., Hanegreefs, J., Hamers-Casterman, C. and Hamers, R. (1990) Molecular cloning and sequence analysis of the gene encoding the major merozoite surface antigen of Plasmodium chabaudi chabaudi IP-PC1. Mol. Biochem. Parasitol. 43, 231-244.
12. McKean, P.G., O'Dea, K. and Brown, K.N. (1993) Nucleotide sequence analysis and epitope mapping of the merozoite surface protein 1 from Plasmodium chabaudi chabaudi AS. Mol. Biochem. Parasitol. 62, 199-209.
13. Toebe, C.S., Clements, J.D., Cardenas, L., Jennings, G.J. and Wiser, M.F. (1997) Recombinant Plasmodium berghei merozoite surface protein-1 expressed in Salmonella: evaluation of immunogenicity in a rodent model. Am. J. Trop. Med. Hyg. 56, in press.
14. Wiser, M.F. (1986) Characterization of monoclonal antibodies directed against erythrocytic stage antigens of Plasmodium berghei. Eur. J. Cell Biol. 42, 45-51.
15. Lyon, J.A., Haynes, J.D., Diggs, C.L., Chulay, J.D., Haidaris, C.D. and Pratt-Rossiter, J. (1987) Monoclonal antibody characterization of the 195 kDa major surface glycoprotein of Plasmodium falciparum malaria schizonts and merozoites: identification of additional processed products and a serotype-restricted repetitive epitope. J. Immunol. 138, 895-901.
16. Stafford, W.H.L., Blackman, M.J., Harris, A., Shai, S., Grainger, M. and Holder, A.A. (1994) N-terminal amino acid sequence of the Plasmodium falciparum merozoite surface protein-1 polypeptides. Mol. Biochem. Parasitol. 66, 157-160.
17. O'Dea, K.P., McKean, P.G., Harris, A. and Brown, K.N. (1995) Processing of the Plasmodium chabaudi chabaudi AS merozoite surface protein 1 in vivo and in vitro. Mol. Biochem. Parasitol. 72, 111-119.
18. Holder, A.A. and Freeman, R.R. (1981) Immunization against blood stage rodent malaria using purified parasite antigens. Nature 294, 361-364.
19. Cooper, J.A., Cooper, L.T. and Saul, A.J. (1992) Mapping of the region predominantly recognized by antibodies to the Plasmodium-falciparum merozoite surface antigen MSA-1. Mol. Biochem. Parasitol. 51, 301-312.
20. Cooper, J.A. and Bujard, H. (1992) Membrane associated proteases process Plasmodium falciparum merozoite surface antigen-1 (MSA-1) to fragment gp41. Mol. Biochem. Parasitol. 56, 151-160.
21. Braun-Breton, C., Blisnick, T., Jouin, H., Barale, J.C., Rabilloud, T., Langsley, G. and Da Silva, L.H.P. (1992) Plasmodium chabaudi p68 serine protease activity required for merozoite entry into mouse erythrocytes. Proc. Natl. Acad. Sci. USA 89, 9647-9651.
22. Schechter, I. and Berger, A. (1967) On the active site in proteases. I. Papain. Biochem. Biophys. Res. Commun. 27, 157-162.