Differentiation-induced changes in the content, secretion, and subcellular distribution of lysosomal cathepsins in the human colon cancer HT-29 cell line

Cell and Tissue Research

Volumn 289, Issue 1, 1997, Pages 109-117

  De Stefanis, Daniela ^a   Démoz, Marina ^a   Dragonetti, Antonella ^a   Houri, Jean Jacques ^b   Ogier Denis, Eric ^b   Codogno, Patrice ^b   Baccino, Francesco M ^a,c   Isidoro, Ciro ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b INSERM   (France)

^c CNR   (Italy)

Author keywords

Enterocytic differentiation; HT 29 colon carcinoma cells; Leupeptin; Lysosomal cathepsins; Tumor cells

Indexed keywords

AMMONIUM CHLORIDE; CATHEPSIN B; CATHEPSIN D; CATHEPSIN L; CHLOROQUINE; LEUPEPTIN; MANNOSE 6 PHOSPHATE;

ARTICLE; CELL DIFFERENTIATION; CELL SECRETION; CELLULAR DISTRIBUTION; HUMAN; HUMAN CELL; LYSOSOME; PRIORITY JOURNAL; TUMOR CELL LINE;

AMMONIUM CHLORIDE; CATHEPSIN B; CATHEPSIN D; CATHEPSINS; CELL DIFFERENTIATION; COLON; COLONIC NEOPLASMS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ENDOPEPTIDASES; HT29 CELLS; HUMANS; LEUPEPTINS; LYSOSOMES; MANNOSEPHOSPHATES;

EID: 0030949251     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410050856     Document Type: Article

References (47)

1. Augeron C, Laboisse CL (1984) Emergence of permanently differentiated cell clones in a human colonic cancer cell line in culture after treatment with sodium butyrate. Cancer Res 44:3961-3969
2. Barrett AJ (1992) Cellular proteolysis: an overview. Ann NY Acad Sci 674:1-15
3. Berg T, Gjöen T. Bakke O (1995) Physiological functions of endosomal proteolysis. Biochem. J. 307:313-326
4. Berquin IM, Sloane BF (1995) Cysteine proteases and tumor progression. Perspectives Drug Discovery Design 2:371-388
5. Campo E, Munoz J, Miquel R, Palacin A, Cardesa A, Sloane BF, Emmert-Buck MR (1994) Cathepsin B expression in colorectal carcinomas correlates with tumor progression and shortened patient survival. Am J Pathol 145:253-262
6. Capony F, Braulke T, Rougeot R, Roux S, Montcourrier P, Rochefort H (1994) Specific mannose 6-phosphate receptor-independent sorting of procathepsin D in breast cancer cells. Exp Cell Res 215:154-163
7. Choi PM, Tchou-Wong KM, Weinstein IB (1990) Overexpression of protein kinase C in HT29 colon cancer cells causes growth inhibition and tumor suppression. Mol Cell Biol 10:4650-4657
8. Figura K von, Hasilik A (1986) Lysosomal enzymes and their receptors. Annu Rev Biochem 55:167-193
9. Fogh J, Trempe G (1975) Human Tumor cells in vitro. Plenum Publishing Corporation, New York
10. Furuno K, Ishikawa T, Kato K (1982) Appearance of autolysosomes in rat liver after leupeptin treatment. J Biochem 91:1485-1494
11. Hanewinkel H, Glossl J, Kresse H (1987) Biosynthesis of cathepsin B in cultured normal and I-cell fibroblasts. J Biol Chem 262:12351-12355
12. Henell F, Glaumann H (1984) Effect of leupeptin on the autophagic vacuolar system of rat hepatocytes. Lab Invest 51:46-56
13. Houri JJ, Ogier-Denis E, Trugnan G, Codogno P (1993) Autophagic degradation of N-linked glycoproteins is downregulated in differentiated human colon adenocarcinoma cells. Biochem Biophys Res Commun 197:805-811
14. Houri JJ, Ogier-Denis E, De Stefanis D, Bauvy C, Baccino FM, Isidoro C, Codogno P (1995) Differentiation-dependent autophagy controls the fate of newly synthesized N-linked glycoproteins in the colon adenocarcinoma HT-29 cell line. Biochem J 309:521-527
15. 4Cl. Eur J Biochem 191:591-597
16. Isidoro C, Démoz M, De Stefanis D, Baccino FM, Bonelli G (1995) High levels of proteolytic enzymes in the ascitic fluid and plasma of rats bearing the Yoshida AH-130 hepatoma. Invasion Metastasis 15:116-124
17. Isidoro C, Baccino FM, Hasilik A (1996) Missorting of procathepsin D in metastogenic tumor cells is not due to impaired synthesis of the phosphomannosyl signal, Int J Cancer 70: 561-566
18. Kominami E, Hashida S, Khairallah EA, Katunuma N (1983) Sequestration of cytoplasmic enzymes in an autophagic vacuolelysosomal system induced by injection of leupeptin. J Biol Chem 258:6093-6100
19. Kominami E, Tsukahara T, Bando Y, Katunuma N (1987) Autodegradation of lysosomal cysteine proteinases. 144:749-756
20. Kornfeld S (1992) Structure and function of the mannose-6-phosphate/insulin like growth factor receptors. Annu Rev Biochem 61:307-330
21. Lesuffler T, Barbat A, Dussaulx E, Zweibaum A (1990) Growth adaptation to methotrexate of HT-29 human colon carcinoma cells is associated with their ability to differentiate into columnar absorptive and mucus-secreting cells. Cancer Res 50: 6334-6343
22. Leto G, Tumminello FM, Russo A, Pizzolanti G, Bazan V, Gebbia N (1994) Cathepsin D activity levels in colorectal cancer: correlation with cathepsin B and L and other biological and clinical parameters. Int J Oncol 5:509-515
23. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with folin phenol reagent. J Biol Chem 193: 265-275
24. Maxfield FR (1982) Weak bases and ionophores rapidly and reversibly raise the pH of endocytic vesicles in cultured mouse fibroblasts. J Cell Biol 95:676-681
25. Muno D, Sutoh N, Watanabe T, Uchiyama Y, Kominami E (1990) Effect of metabolic alterations on the density and the contents of cathepsins B, H and L of lysosomes in rat macrophages. Eur J Biochem 191:91-98
26. Noda T, Farquhar MG (1992) A non-autophagic pathway for diversion of ER secretory proteins to lysosomes. J Cell Biol 119:85-97
27. Ogier-Denis E, Bauvy C, Aubery M, Codogno P, Sapin C, Roussel M, Zweibaum A, Trugnan G (1989) Processing of asparagine-linked oligosaccharides is an early biochemical marker of the enterocytic differentiation of HT-29 cells. J Cell Biochem 41:13-23
28. Pinto M, Appay MD, Simon-Assmann P, Chevalier G, Dracopoli N, Fogh J, Zweibaum A (1982) Enterocytic differentiation of cultured human colon cancer cells by replacement of glucose by galactose in the medium. Biol Cell 44:193-196
29. Pitt A, Mayorga LS, Schwartz AL, Stahl PD (1992) Transport of phagosomal components to an endosomal compartment. J Biol Chem 267:126-132
30. Price JE, Daniels LM, Campbell DE, Giavazzi R (1989) Organ distribution of experimental metastases of a human colorectal carcinoma injected in nude mice. Clin Exp Metastasis 7: 55-68
31. Rochefort H (1990) Biological and clinical significance of cathepsin D in breast cancer. Semin Cancer Biol 1:153-160
32. Roederer M, Mays RW, Murphy RF (1989) Effect of confluence on endocytosis by 3T3 fibroblasts: increased rate of pinocytosis and accumulation of residual bodies. Eur J Cell Biol 48:37-44
33. Saftig P, Hetman M, Schmahl W, Weber K, Heine L, Mossmann H, Köster A, Hess B, Evers M, Figura K von, Peters C (1995) Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells. EMBO J 14:3599-3608
34. Samarel AM, Ferguson AG, Decker RS, Lesch M (1989) Effects of cysteine protease inhibitors on rabbit cathepsin D maturation. Am J Physiol 257:C1069-C1079
35. Schroy PC, Rustgi AK, Ikonomu E, Liu XP, Polito J, Andry C, O'Keane JC (1994) Growth and intestinal differentiation are independently regulated in HT29 colon cancer cells. J Cell Physiol 161:111-123
36. Sekikawa K, Arends JW, Verstijnen CPHJ, Linden E van der, Dinjiens W, Schutte B, Bosman FT (1988) Influence of implantation site on growth, antigen expression and metastatic potential of human colonic cancer HT29 and 5583 xenografts in nude mice. Invasion Metastasis 8:238-252
37. Trugnan G, Rousset M, Chantret I, Barbat A, Zweibaum A (1987) The posttranslational processing of sucrase-isomaltase in HT-29 cells is a function of their state of enterocytic differentiation. J Cell Biol 104:1199-1205
38. Trugnan G, Ogier-Denis E, Sapin C, Darmoul D, Bauvy C, Aubery M, Codogno P (1991) The N-glycan processing in HT-29 cells is a function of their state of enterocytic differentiation. J Biol Chem 266:20849-20855
39. Tumminello FM, Gebbia AN, Pizzolanti G, Russo A, Bazan V, Leto G (1995) Cathepsin D content in colorectal cancer. Oncology 52:237-242
40. Velcich A, Palumbo L, Jarry A, Laboisse C, Racevskis J, Augenlicht L (1995) Patterns of expression of lineage-specific markers during the in vitro-induced differentiation of HT29 colon carcinoma cells. Cell Growth Differ 6:749-757
41. Viallard V, Denis C, Trocheris V, Murat JC (1986) Effect of glutamine deprivation and glutamate or ammonium chloride addition on growth rate, metabolism and differentiation of human colon cancer cell-line HT29. Int J Biochem 18:263-269
42. Wice BM, Gordon JI (1992) A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gutspecific N-myrostilated annexin. J Cell Biol 116:405-422
43. Wice BM, Gordon JI (1995) A tetraspan membrane glycoprotein produced in the human intestinal epithelium and liver that can regulate cell density-dependent proliferation. J Biol Chem 270:21907-21918
44. Wice BM, Trugnan G, Pinto M, Rousset M, Chevalier G, Dussaulx E, Lacroix B, Zweibaum A (1985) The intracellular accumulation of UDP-N-acetylhexosamines is concomitant with the inability of human colon cancer cells to differentiate. J Biol Chem 260:139-146
45. Wilson JM, Whitney JA, Neutra MR (1991) Biogenesis of the apical endosome-lysosome complex during differentiation of absorptive epithelial cells in rat ileum. J Cell Sci 100:133-143
46. Wissig SL, Graney DO (1968) Membrane modifications in the apical endocytic complex of ileal epithelial cells. J Cell Biol 39:564-579
47. Zweibaum A, Pinto M, Chevalier G, Dussaulx E, Triadou N, Lacroix B, Haffen K, Brun JL, Rousset M (1985) Enterocytic differentiation of a subpopulation of the human colon tumor cell line HT-29 selected for growth in sugar-free medium and its inhibition by glucose. J Cell Physiol 122:21-29