A point mutation in the human estrogen receptor gene is associated with the expression of an abnormal estrogen receptor mRNA containing a 69 novel nucleotide insertion

Breast Cancer Research and Treatment

Volumn 44, Issue 2, 1997, Pages 145-151

  Wang, M ^a   Dotzlaw, H ^a   Fuqua, S A W ^b   Murphy, L C ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

Breast cancer; Estrogen receptor; Gene expression; Mutation

Indexed keywords

ESTROGEN RECEPTOR; MESSENGER RNA;

ARTICLE; BREAST BIOPSY; BREAST CANCER; EXON; GENE INSERTION SEQUENCE; HUMAN; HUMAN TISSUE; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; RECEPTOR GENE; TUMOR BIOPSY;

BASE SEQUENCE; BIOPSY; BLOTTING, SOUTHERN; BREAST NEOPLASMS; CELLS, CULTURED; DNA TRANSPOSABLE ELEMENTS; HUMANS; MOLECULAR SEQUENCE DATA; POINT MUTATION; POLYMERASE CHAIN REACTION; RECEPTORS, ESTROGEN; RNA SPLICING; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0030949095     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005753117205     Document Type: Article

References (12)

1. Murphy LC, Wang M, Coutts A, Dotzlaw H: Novel mutations in the estrogen receptor mRNA in human breast cancers. J Clin Endocrinol Metab, in press
2. Sluyser M: Mutations in the estrogen receptor gene. Human Mutation 6: 97-103, 1995
3. Dotzlaw H, Alkhalaf M, Murphy LC: Characterization of estrogen receptor variant mRNAs from human breast cancers. Mol Endocrinol 6: 773-785, 1992
4. Fuqua S, Fitzgerald SD, Chamness GC, Tandon AK, McDonnell DP, Nawaz Z, O'Malley B, McGuire WL: Variant human breast tumor estrogen receptor with constitutive transcriptional activity. Cancer Res 51: 105-109, 1991
5. Fuqua S, Fitzgerald SD, Allred DC, Elledge RM, Nawaz Z, McDonnell DP, O'Malley BW, Greene GL, McGuire WL: Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors. Cancer Res 52: 483-486, 1992
6. Murphy LC, Dotzlaw H, Hamerton J, Schwarz J: Investigation of the origin of variant, truncated estrogen receptor-like mRNAs identified in some human breast cancer biopsy samples. Breast Cancer Res Treat 26: 149-161, 1993
7. Murphy LC, Dotzlaw H: Variant estrogen receptor mRNA species detected in human breast cancer biopsy samples. Mol Endocrinol 3: 687-693, 1989
8. Murphy LC, Hilsenbeck S, Dotzlaw H, Fuqua SAW: Relationship of clone 4 estrogen receptor variant messenger RNA expression to some known prognostic variables in human breast cancer. Clin Cancer Res 1: 155-159, 1995
9. Ponglikitmongkol M, Green S, Chambon P: Genomic organization of the human oestrogen receptor gene. EMBO J 7: 3385-3388, 1988
10. Ziai MR, Giordano A, Armandola E, Ferrone S: Purification by ammonium sulfate precipitation of bacteriophage lambda gt11 DNA for restriction analysis of cloned cDNA inserts. Anal Biochem 171: 192-196, 1988
11. Sambrook J, Fritsch EF, Maniatis T: Molecular cloning, a laboratory manual. Second edition. Cold Spring Harbor Laboratory Press, 1989
12. Green S, Walter P, Kumar V, Krust A, Bornet JM, Argos P, Chambon P: Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 320: 134-139, 1986