Topical glyceryl trinitrate relaxes the sphincter of Oddi

Gut

Volumn 40, Issue 4, 1997, Pages 541-543

  Luman, W ^b   Pryde, A ^b   Heading, R C ^a   Palmer, K R ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

^b ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

Glyceryl trinitrate; Sphincter of Oddi

Indexed keywords

GLYCERYL TRINITRATE;

ADULT; ARTICLE; CLINICAL ARTICLE; ENDOSCOPY; FEMALE; GASTROINTESTINAL MOTILITY; HUMAN; MALE; MANOMETRY; ODDI SPHINCTER; PRIORITY JOURNAL; TOPICAL DRUG ADMINISTRATION;

EID: 0030949018     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.40.4.541     Document Type: Article

References (22)

1. Behar J, Biancani P. Pharmacologic characterisations of excitatory and inhibitory cholecystokinin receptors of the cat gallbladder and sphincter of Oddi. Gastroenterology 1987; 92: 764-70.
2. G-monomethyl L-arginine on the response of the rat anococygeus muscle to NANC nerve stimulation. Br J Pharmacol 1989; 98: 1080-2.
3. G-nitro arginine inhibit non-adrenergic, non-cholinergic relaxation of the mouse anococygeus muscle. Br J Pharmacol 1990; 99: 602-6.
4. Bult H, Boeckxstaens GE, Pelckmans PA, Jordaens FH, Van Maercke YM, Herman AG. Nitric oxide as an inhibitory non-adrenergic non-cholinergic neuro-transmitter. Nature 1990; 345: 346-7.
5. Slivka A, Chuttani R, Carr-Locke DL, et al. Inhibition of sphincter of Oddi function by the nitric oxide carrier S-nitroso-N-acetylcysteine in rabbits and humans. J Clin Invest 1994; 94: 1792-8.
6. Toouli J, Roberts-Thompson IC, Dent J, Lee J. Manometric disorders in patients with suspected sphincter of Oddi dysfunction. Gastroenterology 1985; 88: 1243-50.
7. Geenen JE, Hogan WJ, Dodds WJ, Toouli J, Venu RP. The efficacy of endoscopic sphincterotomy after cholecystectomy in patients with sphincter of Oddi dysfuncion. N Engl J Med 1989; 320: 320-7.
8. Guelrud M, Mendoza S, Rossiter G, Villegas MI. Sphincter of Oddi in healthy volunteers. Dig Dis Sci 1990; 35: 38-46.
9. Funch-Jensen P. The clinical value of sphincter of Oddi manometry. In: The sphincter of Oddi primer for the pancreaticobiliary endoscopist. Philadelphia: WB Saunders, 1993: 119-31.
10. Stark ME, Szurszewski JH. Role of nitric oxide in gastrointestinal and hepatic function and disease. Gastroenterology 1991; 103: 1928-49.
11. Ignarro LJ, Buga GM, Wood KS, Byms RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987; 84: 9265-9.
12. Worthy CS, Baker RA, Iannos J, Saccone GTP, Toouli J. Human fasting and postprandial sphincter of Oddi motility. Br J Surg 1989; 76: 709-14.
13. Toouli J, Hogan WJ, Geenen JE, Dodds WJ, Amdorfer RC. Action of cholecystokinin-octapeptide on sphincter of Oddi basal pressure and phasic wave activity in humans. Surgery 1980; 92: 497-503.
14. Kaufman HS, Shermak MA, May CA, Pitt HA, Lillemoe KD. Nitric oxide inhibits resting sphincter of Oddi activity. Am J Surg 1995; 165: 74-80.
15. Thune A, Delbro DS, Nilson B, Friman S, Svanvik J. Role of nitric oxide in motility and secretions of the feline hepatobiliary tract. Scand J Gastroenterol 1995; 30: 715-20.
16. Baker RA, Saccone GTP, Brookes SJH, Toouli J. Nitric oxide mediates nonadrenergic, noncholinergic neural relaxation in the australian possum. Gastroenterology 1993; 105: 1746-53.
17. Mourelle M, Guarner F, Moncada S, Malagelada J. The arginine/nitric oxide pathway modulates sphincter of Oddi motor activity in guinea pigs and rabbits. Gastroenterology 1993; 105: 1299-305.
18. Toouli J, Baker RA. Innervation of the sphincter of Oddi: physiology and considerations of pharmacological intervention in biliary dyskinesia. Pharmacol Ther 1991; 49: 269-81.
19. Cuer JC, Abergel A, Dapoigny M, Lhopital F, Bommelaer G, Laugier R. The efficacy of glyceryl trinitrate in patients with sphincter of Oddi dysfunction. A prospective double-blind study. Gastroenterology 1995; 108: A412.
20. Staritz M, Poralla T, Ewe K, Meyer zum Buschenfelde K. Effect of glyceryltrinitrate on the sphincter of Oddi motility and baseline pressure. Gut 1985; 26: 194-7.
21. Staritz M, Poralla T, Dormeyer H, Meyer ZBK-H. Endoscopic removal of common bile duct stones through the intact papilla after medical sphincter dilation. Gastroenterology 1985; 88: 1807-11.
22. Donnellan I, Hallissey M, Nwokolo C, Loft D, Fraser I. Sublingual GTN spray improves success at ERCP cannulation [abstract]. Gut 1994; 35 (suppl 5): S36.