-
1
-
-
0025006310
-
Biosynthesis of anthracyclines: Analysis of mutants of Streptomyces sp. strain C5 blocked in daunomycin biosynthesis
-
Bartel, P. L., N. C. Connors, and W. R. Strohl. 1990. Biosynthesis of anthracyclines: analysis of mutants of Streptomyces sp. strain C5 blocked in daunomycin biosynthesis. J. Gen. Microbiol. 136:1877-1886.
-
(1990)
J. Gen. Microbiol.
, vol.136
, pp. 1877-1886
-
-
Bartel, P.L.1
Connors, N.C.2
Strohl, W.R.3
-
2
-
-
0028351394
-
Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin
-
Bibb, M. J., D. H. Sherman, S. Ömura, and D. A. Hopwood. 1994. Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin. Gene 142:31-39.
-
(1994)
Gene
, vol.142
, pp. 31-39
-
-
Bibb, M.J.1
Sherman, D.H.2
Ömura, S.3
Hopwood, D.A.4
-
3
-
-
0027178455
-
An inexpensive and simple method for DNA purification on silica particles
-
Carter, M. J., and I. D. Milton. 1993. An inexpensive and simple method for DNA purification on silica particles. Nucleic Acids Res. 21:1044.
-
(1993)
Nucleic Acids Res.
, vol.21
, pp. 1044
-
-
Carter, M.J.1
Milton, I.D.2
-
4
-
-
0025082417
-
Biosynthesis of anthracyclines: Enzymic conversion of aklanonic acid to aklavinone and ε-rhodomycinone by anthracycline-producing strcptomycetes
-
Connors, N. C., P. L. Bartel, and W. R. Strohl. 1990. Biosynthesis of anthracyclines: enzymic conversion of aklanonic acid to aklavinone and ε-rhodomycinone by anthracycline-producing strcptomycetes. J. Gen. Microbiol. 136:1887-1894.
-
(1990)
J. Gen. Microbiol.
, vol.136
, pp. 1887-1894
-
-
Connors, N.C.1
Bartel, P.L.2
Strohl, W.R.3
-
6
-
-
0029941712
-
Isolation and characterization of a gene from Streptomyces sp. strain C5 that confers on Streptomyces lividans TK24 the ability to convert daunomycin to doxorubicin
-
Dickens, M. L., and W. R. Strohl. 1996. Isolation and characterization of a gene from Streptomyces sp. strain C5 that confers on Streptomyces lividans TK24 the ability to convert daunomycin to doxorubicin. J. Bacteriol. 178:3389-3395.
-
(1996)
J. Bacteriol.
, vol.178
, pp. 3389-3395
-
-
Dickens, M.L.1
Strohl, W.R.2
-
7
-
-
0028952580
-
Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5
-
Dickens, M. L., J. Ye, and W. R. Strohl. 1995. Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5. J. Bacteriol. 177:536-543.
-
(1995)
J. Bacteriol.
, vol.177
, pp. 536-543
-
-
Dickens, M.L.1
Ye, J.2
Strohl, W.R.3
-
8
-
-
0029996757
-
Cloning, sequencing and analysis of aklaviketone reductase from Streptomyces sp. strain C5
-
Dickens, M. L., J. Ye, and W. R. Strohl. 1996. Cloning, sequencing and analysis of aklaviketone reductase from Streptomyces sp. strain C5. J. Bacteriol. 178:3384-3388.
-
(1996)
J. Bacteriol.
, vol.178
, pp. 3384-3388
-
-
Dickens, M.L.1
Ye, J.2
Strohl, W.R.3
-
9
-
-
0022002177
-
Isolation and chemical structure of aklanonic acid, an early intermediate in the biosynthesis of anthracvclines
-
Eckardt, K., D. Tresselt, G. Schumann, W. Ihn, and C. Wagner. 1985. Isolation and chemical structure of aklanonic acid, an early intermediate in the biosynthesis of anthracvclines. J. Antibiot. 38:1034-1039.
-
(1985)
J. Antibiot.
, vol.38
, pp. 1034-1039
-
-
Eckardt, K.1
Tresselt, D.2
Schumann, G.3
Ihn, W.4
Wagner, C.5
-
10
-
-
0020793569
-
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
-
Feinberg, A. P., and B. Fogelstein. 1983. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132:6-13. (Addendum. Anal. Biochem. 137:266-267, 1984.)
-
(1983)
Anal. Biochem.
, vol.132
, pp. 6-13
-
-
Feinberg, A.P.1
Fogelstein, B.2
-
11
-
-
0021381028
-
-
Feinberg, A. P., and B. Fogelstein. 1983. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132:6-13. (Addendum. Anal. Biochem. 137:266-267, 1984.)
-
(1984)
Addendum. Anal. Biochem.
, vol.137
, pp. 266-267
-
-
-
12
-
-
0027971383
-
DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2)
-
Fernández-Moreno, M. A., E. Martinez, J. L. Caballero, K. Ichinose, D. A. Hopwood, and F. Malpartida. 1994. DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2). J. Biol. Chem. 269:24854-24863.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 24854-24863
-
-
Fernández-Moreno, M.A.1
Martinez, E.2
Caballero, J.L.3
Ichinose, K.4
Hopwood, D.A.5
Malpartida, F.6
-
13
-
-
0028555349
-
Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase
-
Grimm, A., K. Madduri, A. Ali, and C. R. Hutchinson. 1994. Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase. Gene 151:1-10.
-
(1994)
Gene
, vol.151
, pp. 1-10
-
-
Grimm, A.1
Madduri, K.2
Ali, A.3
Hutchinson, C.R.4
-
14
-
-
0028841535
-
Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases
-
Haydock, S. F., J. F. Aparicio, I. Molnár, T. Schwecke, L. E. Khaw, A. König, A. F. A. Marsden, I. S. Galloway, J. Staunton, and P. F. Leadlay. 1995. Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases. FEBS Lett. 374:246-248.
-
(1995)
FEBS Lett.
, vol.374
, pp. 246-248
-
-
Haydock, S.F.1
Aparicio, J.F.2
Molnár, I.3
Schwecke, T.4
Khaw, L.E.5
König, A.6
Marsden, A.F.A.7
Galloway, I.S.8
Staunton, J.9
Leadlay, P.F.10
-
15
-
-
0003728297
-
-
The John Innes Foundation, Norwich. England
-
Hopwood, D. A., M. J. Bibb, K. F. Chater, T. Kieser, C. J. Bruton, H. M. Kieser, D. J. Lydiate, C. P. Smith, J. M. Ward, and H. Schrempf. 1985. Genetic manipulation of Streptomyces: a laboratory manual. The John Innes Foundation, Norwich. England.
-
(1985)
Genetic Manipulation of Streptomyces: A Laboratory Manual
-
-
Hopwood, D.A.1
Bibb, M.J.2
Chater, K.F.3
Kieser, T.4
Bruton, C.J.5
Kieser, H.M.6
Lydiate, D.J.7
Smith, C.P.8
Ward, J.M.9
Schrempf, H.10
-
16
-
-
0025606149
-
Molecular genetics of polyketides and its comparison to fatty acid biosynthesis
-
Hopwood, D. A., and D. H. Sherman. 1990. Molecular genetics of polyketides and its comparison to fatty acid biosynthesis. Annu. Rev. Genet. 24:37-66.
-
(1990)
Annu. Rev. Genet.
, vol.24
, pp. 37-66
-
-
Hopwood, D.A.1
Sherman, D.H.2
-
17
-
-
0029445179
-
Anthracyclines
-
L. C. Vining and C. Stuttard (ed.), Butterworth-Heinemann, Boston
-
Hutchinson, C. R. 1995. Anthracyclines, p. 331-357. In L. C. Vining and C. Stuttard (ed.), Genetics and biochemistry of antibiotic production. Butterworth-Heinemann, Boston.
-
(1995)
Genetics and Biochemistry of Antibiotic Production
, pp. 331-357
-
-
Hutchinson, C.R.1
-
18
-
-
85036443742
-
-
Personal communication
-
Hutchinson, C. R. Personal communication.
-
-
-
Hutchinson, C.R.1
-
19
-
-
0028811381
-
Polyketide synthase gene manipulation: A structure-function approach in engineering novel antibiotics
-
Hutchinson, C. R., and I. Fujii. 1995. Polyketide synthase gene manipulation: a structure-function approach in engineering novel antibiotics. Annu. Rev. Microbiol. 49:201-238.
-
(1995)
Annu. Rev. Microbiol.
, vol.49
, pp. 201-238
-
-
Hutchinson, C.R.1
Fujii, I.2
-
20
-
-
0027459427
-
Derivatives of pUC18 that have Bg/II sites flanking a modified multiple cloning site and that retain the ability to identify recombinant clones by visual screening of Escherichia coli
-
Janssen, G. R., and M. J. Bibb. 1993. Derivatives of pUC18 that have Bg/II sites flanking a modified multiple cloning site and that retain the ability to identify recombinant clones by visual screening of Escherichia coli. Gene 124:133-134.
-
(1993)
Gene
, vol.124
, pp. 133-134
-
-
Janssen, G.R.1
Bibb, M.J.2
-
21
-
-
0027382486
-
Polyketide biosynthesis; prospects for hybrid antibiotics
-
Katz, L., and S. Donadio. 1993. Polyketide biosynthesis; prospects for hybrid antibiotics. Annu. Rev. Microbiol. 47:875-912.
-
(1993)
Annu. Rev. Microbiol.
, vol.47
, pp. 875-912
-
-
Katz, L.1
Donadio, S.2
-
22
-
-
0027315216
-
Genetic construction and functional analysis of hybrid polyketide synthases containing heterologous acyl carrier proteins
-
Khosla, C., R. McDaniel, S. Ebert-Khosla, R. Torres, D. H. Sherman, M. J. Bibb, and D. A. Hopwood. 1993. Genetic construction and functional analysis of hybrid polyketide synthases containing heterologous acyl carrier proteins. J. Bacteriol. 175:2197-2204.
-
(1993)
J. Bacteriol.
, vol.175
, pp. 2197-2204
-
-
Khosla, C.1
McDaniel, R.2
Ebert-Khosla, S.3
Torres, R.4
Sherman, D.H.5
Bibb, M.J.6
Hopwood, D.A.7
-
24
-
-
0022587404
-
Transformation and transfection of anthracycline-producing streptomycetes
-
Lampel, J. S., and W. R. Strahl. 1986. Transformation and transfection of anthracycline-producing streptomycetes. Appl. Environ. Microbiol. 51:126-131.
-
(1986)
Appl. Environ. Microbiol.
, vol.51
, pp. 126-131
-
-
Lampel, J.S.1
Strahl, W.R.2
-
25
-
-
0027218231
-
Saccharopolyspora hirsuta 367 encodes clustered genes similar to ketoacyl synthase, ketoacyl reductase, acyl carrier protein, and biotin carboxyl carrier protein
-
Le Gouill, C., D. Desmarais, and C. V. Dary. 1993. Saccharopolyspora hirsuta 367 encodes clustered genes similar to ketoacyl synthase, ketoacyl reductase, acyl carrier protein, and biotin carboxyl carrier protein. Mol. Gen. Genet. 240:146-150.
-
(1993)
Mol. Gen. Genet.
, vol.240
, pp. 146-150
-
-
Le Gouill, C.1
Desmarais, D.2
Dary, C.V.3
-
26
-
-
0029934431
-
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin
-
Lombó, F., G. Blanco, E. Fernández, C. Méndez, and J. A. Salas. 1996. Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin. Gene 172:87-91.
-
(1996)
Gene
, vol.172
, pp. 87-91
-
-
Lombó, F.1
Blanco, G.2
Fernández, E.3
Méndez, C.4
Salas, J.A.5
-
27
-
-
0027908014
-
Engineered biosynthesis of novel polyketides
-
McDaniel, R., S. Ebert-Khosla, D. A. Hopwood, and C. Khosla. 1993. Engineered biosynthesis of novel polyketides. Science 262:1546-1550.
-
(1993)
Science
, vol.262
, pp. 1546-1550
-
-
McDaniel, R.1
Ebert-Khosla, S.2
Hopwood, D.A.3
Khosla, C.4
-
28
-
-
0029022267
-
Daunorubicin type II polyketide synthase enzymes DpsA and DpsB determine neither the choice of starter unit nor the cyclization pattern of aromatic polyketides
-
Meurer, G., and C. R. Hutchinson. 1995. Daunorubicin type II polyketide synthase enzymes DpsA and DpsB determine neither the choice of starter unit nor the cyclization pattern of aromatic polyketides. J. Am. Chem, Soc. 117:5899-5900.
-
(1995)
J. Am. Chem, Soc.
, vol.117
, pp. 5899-5900
-
-
Meurer, G.1
Hutchinson, C.R.2
-
30
-
-
0029059472
-
Purification of a malonyltransferase from Streptomyces coelicolor A3(2) and analysis of its genetic determinant
-
Revill, W. P., M. J. Bibb, and D. A. Hopwood. 1995. Purification of a malonyltransferase from Streptomyces coelicolor A3(2) and analysis of its genetic determinant. J. Bacteriol. 177:3947-3952.
-
(1995)
J. Bacteriol.
, vol.177
, pp. 3947-3952
-
-
Revill, W.P.1
Bibb, M.J.2
Hopwood, D.A.3
-
31
-
-
0029841660
-
Relationships between fatty acid and polyketide synthases from Streptomyces coelicolor A3(2): Characterization of the fatty acylsynthase acyl carrier protein
-
Revill, W. P., M. J. Bibb, and D. A. Hopwood. 1996. Relationships between fatty acid and polyketide synthases from Streptomyces coelicolor A3(2): characterization of the fatty acylsynthase acyl carrier protein. J. Bacteriol. 178: 5660-5667.
-
(1996)
J. Bacteriol.
, vol.178
, pp. 5660-5667
-
-
Revill, W.P.1
Bibb, M.J.2
Hopwood, D.A.3
-
32
-
-
0003903343
-
-
Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
-
Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
-
(1989)
Molecular Cloning: A Laboratory Manual, 2nd Ed.
-
-
Sambrook, J.1
Fritsch, E.F.2
Maniatis, T.3
-
33
-
-
0029019944
-
The Streptomyces glaucescens tcmKL polyketide synthase and tcmN polyketide cyclase genes govern the size and shape of aromatic polyketides
-
Shen, B., R. G. Summers, E. Wendt-Pientkowski, and C. R. Hutchinson. 1995. The Streptomyces glaucescens tcmKL polyketide synthase and tcmN polyketide cyclase genes govern the size and shape of aromatic polyketides. J. Am. Chem. Soc. 117:6811-6821.
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 6811-6821
-
-
Shen, B.1
Summers, R.G.2
Wendt-Pientkowski, E.3
Hutchinson, C.R.4
-
34
-
-
0002630228
-
Biosynthesis of natural and hybrid polyketides by anthracyclineproducing streptomycetes
-
C. L. Hershberger, S. W. Queener, and G. Hegeman (ed.), American Society for Microbiology, Washington, D.C.
-
Strohl, W. R., P. L. Bartel, N. C. Connors, C.-B. Zhu, D. C. Dosch, J. M. Beale, Jr., H. G. Floss, K. Stutzman-Engwall, S. L. Otten, and C. R. Hutchinson. 1989. Biosynthesis of natural and hybrid polyketides by anthracyclineproducing streptomycetes, p. 68-84. In C. L. Hershberger, S. W. Queener, and G. Hegeman (ed.), Genetics and molecular biology of industrial microorganisms. American Society for Microbiology, Washington, D.C.
-
(1989)
Genetics and Molecular Biology of Industrial Microorganisms
, pp. 68-84
-
-
Strohl, W.R.1
Bartel, P.L.2
Connors, N.C.3
Zhu, C.-B.4
Dosch, D.C.5
Beale Jr., J.M.6
Floss, H.G.7
Stutzman-Engwall, K.8
Otten, S.L.9
Hutchinson, C.R.10
-
35
-
-
0026515223
-
Significance of anthraquinone formation resulting from the cloning of actinorhodin genes in heterologous streptomycetes
-
Strohl, W. R., and N. C. Connors. 1992. Significance of anthraquinone formation resulting from the cloning of actinorhodin genes in heterologous streptomycetes. Mol. Microbiol. 6:147-152.
-
(1992)
Mol. Microbiol.
, vol.6
, pp. 147-152
-
-
Strohl, W.R.1
Connors, N.C.2
-
36
-
-
0002686223
-
Anthracyclines
-
W. R. Strohl (ed.), Marcel-Dekker. Inc., New York
-
Strohl, W. R., M. L. Dickens, V. B. Rajgarhia, A. Woo, and N. D. Priestley. 1997. Anthracyclines, p. 577-658. In W. R. Strohl (ed.), Biotechnology of antibiotics. 2nd ed. Marcel-Dekker. Inc., New York.
-
(1997)
Biotechnology of Antibiotics. 2nd Ed.
, pp. 577-658
-
-
Strohl, W.R.1
Dickens, M.L.2
Rajgarhia, V.B.3
Woo, A.4
Priestley, N.D.5
-
37
-
-
0026537421
-
Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius
-
Stutzman-Engwall, K. J., S. L. Otten, and C. R. Hutchinson. 1992. Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius. J. Bacteriol. 174:144-154.
-
(1992)
J. Bacteriol.
, vol.174
, pp. 144-154
-
-
Stutzman-Engwall, K.J.1
Otten, S.L.2
Hutchinson, C.R.3
-
38
-
-
0029125339
-
Malonyl-coenzyme Aracyl carrier protein acyltransferase of Streptomyces glaucescens: A possible link between fatty acid and polyketide biosynthesis
-
Summers. R. G., A. Ali, B. Shen, W. A. Wessel, and C. R. Hutchinson. 1995. Malonyl-coenzyme Aracyl carrier protein acyltransferase of Streptomyces glaucescens: a possible link between fatty acid and polyketide biosynthesis. Biochemistry 34:9389-9402.
-
(1995)
Biochemistry
, vol.34
, pp. 9389-9402
-
-
Summers, R.G.1
Ali, A.2
Shen, B.3
Wessel, W.A.4
Hutchinson, C.R.5
-
39
-
-
0020451893
-
Physical analysis of antibiotic-resistance genes from Streptomyces and their use in vector construction
-
Thompson, C. J., T. Kieser, J. M. Ward, and D. A. Hopwood. 1982. Physical analysis of antibiotic-resistance genes from Streptomyces and their use in vector construction. Gene 20:51-62.
-
(1982)
Gene
, vol.20
, pp. 51-62
-
-
Thompson, C.J.1
Kieser, T.2
Ward, J.M.3
Hopwood, D.A.4
-
40
-
-
0024419124
-
Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus)
-
Vara, J., M. Lewandowska-Skarbek, Y.-G. Wang, S. Donadio, and C. R. Hutchinson. 1989. Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus). J. Bacteriol. 171:5872-5881.
-
(1989)
J. Bacteriol.
, vol.171
, pp. 5872-5881
-
-
Vara, J.1
Lewandowska-Skarbek, M.2
Wang, Y.-G.3
Donadio, S.4
Hutchinson, C.R.5
-
41
-
-
0021943518
-
Improved M13 phage cloning vectors and host strains: Nucleotide sequences of the M13mpl8 and pUC19 vectors
-
Yanisch-Perron, C., J. Vieira, and J. Messing. 1985. Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors. Gene 33:103-119.
-
(1985)
Gene
, vol.33
, pp. 103-119
-
-
Yanisch-Perron, C.1
Vieira, J.2
Messing, J.3
-
42
-
-
0027993189
-
Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5
-
Ye, J., M. L. Dickens. R. Plater, Y. Li, J. Lawrence, and W. R. Strohl. 1994. Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5. J. Bacteriol. 176:6270-6280.
-
(1994)
J. Bacteriol.
, vol.176
, pp. 6270-6280
-
-
Ye, J.1
Dickens, M.L.2
Plater, R.3
Li, Y.4
Lawrence, J.5
Strohl, W.R.6
|