Dopaminergic sensitization: Implications for the pathogenesis of schizophrenia

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 21, Issue 1, 1997, Pages 23-46

  GlenthØj, Birte Y ^a   Hemmingsen, Ralf ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

behavioural sensitization; dopamine; glutamate; kindling; schizophrenia; ventral tegmental area

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DOPAMINE RECEPTOR; GLUTAMATE RECEPTOR; HALOPERIDOL; RACLOPRIDE;

ANIMAL EXPERIMENT; DOPAMINERGIC SYSTEM; HUMAN; NERVE CELL NETWORK; NEUROTRANSMISSION; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PSYCHOSIS; RAT; REVIEW; SCHIZOPHRENIA;

ANIMALS; DOPAMINE; HUMANS; SCHIZOPHRENIA;

EID: 0030948327     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(96)00158-3     Document Type: Review

References (103)

1. AKBARIAN, S, VINUELA, A., KIM, J.J., POTKIN, S.G., BUNNEY, W.E. and JONES, E.G. (1993a) Distorted distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase neurons in temporal lobe of schizohrenics implies anomalous cortical development. Arch. Gen. Psychiatry 50: 178-187.
2. AKBARIAN, S., BUNNEY, W.E., POTKIN, S.G. Wigal, S.B., Hagman, J.O., Sandman, C.A. and Jones, E.G. (1993b) Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaporase cells in frontal lobe of schizophrenics implies disturbances of cortical development. Arch. Gen. Psychiatry 50:169-177.
3. AKIYAMA, K., KANZAKI, A., TSUCHIDA K. and UJIKE, H. (1994) Metamphetamine-induced behavioral sensitization and its implications for relapse of schizophrenia. Schizophrenia Res. 12:251-257.
4. ALEXANDER, G.E. and CRUTCHER, M.D. (1990) Functional architecture of basal ganglia circuits: Neural substrates of parallel processing. TINS, 13:7:266-271.
5. ALEXANDER, G.E. (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Ann. Rev. Neurosci. 9: 357-381.
6. ALEXANDER, C.E., CRUTCHER, M.D. and DELONG, M.R. (1990) Basal ganglia-thalamocortical circuits: Parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions. Progess. Brain Res. 85: 119-146.
7. ANDREASEN, N.C., ARNDT, ST., SWAYZE II. V, CIZADLO, T., FLAUM, M., O'LEARY, D., ERHARDT, J.C. and YUH, W.T.C. (1994) Thalamic abnormalities in schizophrenia visualized through magnetic resonance image averaging. Science 266: 294-221.
8. ARNOLD S.E., HYMAN, B.T., VAN HOESE, G.W. and DAMASIO, A.R. (1991) Some c yto architectural abnormalities of the entorhinal cortex in schizophrenia. Arch. Gen. Psychiatry 48: 625-632.
9. ARNOLD, S.E., FRANZ, B.R., GUR, R.C., SHAPIRO, R.M., MOBERG, P.J. and TROJANOWSKISKI J.Q. (1995) Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions. Am. J. Psychiatry 152: 738-748.
10. BENES, F.M. (1993) Neurobiological investigations in cingulate cortex of schizophrenic brain. Schizophrenia Bulletin. 19: 537-549.
11. BENES, F.M., MCSPARREN, J., BIRD E.D., SAS GIOVANNI, J.P. and VINCENT, S.L. (1991a) Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoafektive patients. Arch. Gen. Psychiatry 48: 996-1001.
12. BENES, F.M., SØRENSEN, I. and BIRD, E.D. (1991b) Reduced neuronal size in posterior hippocampus of schizophrenic patients. Schizophr. Bull. 17:4: 997-608.
13. BLOOM, F.E. (1993) Advancing a neurodevelopmental origin for schizophrenia. Arch. Gen. Psychiatry 50: 224-227.
14. BRAFF, L.D. (1993) Information processing and attention dysfunctions in schizophrenia. Schizophr. Bull. 19:2: 233-259.
15. CARLSSON, M. and CARLSSON, A. (1990) Interactions between glutamatergic and monoaminergic systems within the basal ganglia - Implications for schizophrenia and Parkinson's disease. TINS. 13:7: 272-276.
16. CARLSSON, A. (1978) Antipsychotic drugs, neurotransmitters, and schizohphrenia. Am. J. Psychiatry 135:2: 164-173.
17. CARLSSON, A. (1988) The current status of the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 1:3: 179-186.
18. CAVALHEIRO, E.A., FERNANDES, M.J., TURSKI, L. and NAFFAH-MASSACORATTI, M.G. (1994) Spontaneous recurrent seizures in rats: amino acid and monoamine. Epilepsia 35:1: 1-11.
19. CLARKE, P.B.S., JAKUBOVIC, A. and FIBIGER, H.C. (1988) Anatomical analysis of the involvement of mesolimbocortical dopamine in the locomotor stimulant action of d-amphetamine and apomorphine. Psychopharmacology 96: 511-520.
20. COSTALL, B. and NAYLOR, R.J. (1974) Extrapyramidal and mesolimbic involvement with the stereotypic activity og D- and L-amphetamine. Eur. J. Pharmacol. 25: 121-129.
21. COSTALL, B. and NAYLOR, R.J. (1977) Mesolimbic and extrapyramidal sites for the mediation of stereotypes behavior patterns and hyperactivity by amphetamine and apomorphine. In: Cocaine and other stimulants. Advances in behavioral biology, pp 47-76, Ellingwood EH, Kilbye MM, eds., New York, Plenum Press.
22. CRAWLEY, J.C.W., CROW, T.J., JOHNSTONE, E.C., OLDLAND, S.R.D., OWENS, D.G.C., POULTER, M., SMITH, T., VEALL, N. and ZANELLI, G.D. (1986a) Dopamine receptors in schizophrenia studied in vivo. Lancet 2: 224-225.
23. 77Br-spiperone in the striata of schizophrenic patients and controls. Nucl. Med. Commun. 7: 599-607.
24. CSERNANSKY, J.G. and NEWCOMER, J.W. (1994) Are There Neurochemical Indicators of Risk for Schizophrenia? Schizophr. Bull. 20 (1): 75-88.
25. DAVIS, K.L., KAHN, R.S., KO, G. and DAVIDSON, M. (1991) Dopamine in schizophrenia: A review and reconceptualization. Am. J. Psychiatry 148:11: 1474-1486.
26. DEAKIN, J.F.W., SLATER, P., SIMPSON, M.D.C., GILCHIST, A.C. and SKAN, W.J. (1989) Frontal cortical and left temporal glutamatergic dysfunction in schizophrenia. J. Neurochem. 52:6: 1781-1786.
27. DEGREEF, G., ASHTARI, M., BOGERTS, B., BILDER, R.M., JODY, D.M., ALVIR, J.M.J. and LIEBERMAN, J.A. (1992) volumes of ventricular system subdivisions measured from magnetic resonance images in first-episode schizophrenic patients. Arch. Gen. Psychiatry 49: 531-537.
28. DUNCAN, E., WOLKIN, A., ANGRIST, B., Sanfilipo, M., Wieland, S., Cooper, T.B. and Rotrosen, J. (1993) Plasma homovanillic acid in neuroleptic responsive and nonresponsive schizophrenics. Biol. Psych. 15:34 (8): 523-8.
29. ELKASHEF, A.M., BUCHANAN, R.W., GELLAD, F., MUNSON, M.A. and BREIR, A. (1994) Basal Ganglia pathology in schizophrenia and tardive dyskinesia: An MRI quantitative study. Am. J. Psychiatry 151:5: 752-755.
30. FALKAI, P. and BOGERTS, B. (1986) Cell loss in the hippocampus of schizophrenics. Aur. Arch. Psychiatr. Neurol. Sci. 236: 154-161.
31. FALKAI, P. and BOGERTS, B. and ROZUMEK, M. (1988) Limbic pathology in schizophrenia: The entorhinal region - A morphometric study. Biol. Psychiatry 24: 515-521.
32. 2 -dopamine receptors in neuroleptic-naive schizophrenic patients. Arch. Gen. Psychiatry 47: 231-219.
33. GELBARD, H.A. and APPLEGATE, C.D. (1994) Persistent increases in dopamine D2 receptor mRNA expression in basal ganglia following kindling. Epilepsy Res. 17 (1): 23-9.
34. GELOWITZ, D.L. and KOKKINIDIS, L. (1993) The effects of amygdaloid stimulation on amphetamine-elicited locomotor sensitization. Brain Res. Bull. 32 (6): 561-5.
35. GEYER, M.A., WILKINSON, L.S., HUMBY, T. and ROBBINS, T.W. (1993) Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle simular to that in schizophrenia. Biol. Psychiatry 34 (6): 361-72.
36. GLENTHØJ, B., HEMMINGSEN, R. and BOLWIG, T.G. (1988) Kindling: A model for the development of tardive dyskinesia? Behavioural Neurology 1: 29-40.
37. GLENTHØJ, B., MOGENSEN, J., LAURSEN, H., HOLM, S. and HEMMINGSEN, R. (1993a) Electrical sensitization of the meso-limbic dopaminergic system in rats: a pathogenetic model for schizophrenia. Brain Res. 619: 39-54.
38. GLENTHØJ, B. HEMMINGSEN, R., ALLERUP, P., BARRY, D., BRUHN, T. and BOLWIG, T.G. (1993b) Electrical amygdala kindling of rats treated discontinuously or continuously with haloperidol. Eur. J. Pharmacol. 236: 401-409.
39. GLENTHØJ, B. (1995) The brain dopaminergic system: Pharmacological, behavioural and electrophysiological studies. Dan. Med. Bull. 42:1: 1-21.
40. GODDARD, G.V., McINTYRE, D.C. and LECH, C.K. (1969) A permanent change in brain function resulting from daily electical stimulation. Ecp. Neurology 25: 295-330.
41. GRACE, A.A. (1991) Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia. Neuroscience 41:1: 1-24.
42. GRAHAM, S.R. and KOKKINIDIS, L. (1993) Clozapine inhibits limbic system kindling: Implications for antipsychotic action. Brain Res. Bull. 30 (5-6): 597-605.
43. GRENHOFF, J. (1990) Firing Pattern in Midbrain dopamine Neurons. A pharmacological study in the rat. Kongl. Carolinska Medico Chirurgiska Instittutet, Department of pharmacology, Karolinska Institutet, S-171 77 Stockholm.
44. GRENHOFF, J., TUNG, G.S. and SVENSSON, T.H. (1988) The exitatory amino acid antagonist kynurenate induces pacemaker-like firing of dopamine neurons in rat ventral tegmental area in vivo. Acta Physiol. Scand. 134: 567-568.
45. HÄFNER, H., RIECHER-RÖSSLER, A., AN der HEIDEN W., MAURER, K., FÄTKHENHEUR, B. and LÖFFLER, W. (1993) Generating and testning a causal explanation of the gender difference in age at first onset of schizophrenia. Psychal. Med. 23: 925-940.
46. HARACZ, J.L. (1982) An overview of studies with schizophrenic patients. Schizophrenia Bull. 8: 438-479.
47. HARRISON, P.J., McLAUGHLIN, D. and KERWIN, R.W. (1991) Decreased hippocampal expression of a glutamate receptor gene in schizophrenia. Lancet 337: 450-2.
48. HEMMINGSEN, R., GLENTHØJ, B. and RUBIN, P. (1995) Maluttunement of the cortical network in skizophrenia: Association of psychopathology and neurobiology. In: Schizophrenia, Alfred Benzon Symposium 38, R. Fog, J. Gerlach, R. Hemmingsen (Eds.), pp 60-70, Munksgaard, Copenhagen.
49. 11C]methylspiperone and PET. J. Cereb. Blood Flow Metab. 5 (Suppl. I): 191-192.
50. HIRATA, A. (1975) A monkey model for schizophrenia produced by methamphetamine. In: Contempory Primatology, Kondo, S., Kawai M. and Ehara A. (Eds.), pp 502-507, Karger, Basel.
51. HIETALA, J., SYVALAHTI, E., VUORIO, K. Någren, K., Lehikoinen, P., Ruotsalainen, U, Räkköläinen, V., Lehtinen, V. and Wegelius, U. (1994) Striatal D2 dopamine receptor characteristics in neuroleptic-naive schizophrenic patients studied with positron emission tomography. Arch. Gen. Psychiatry 51 (2): 116-23.
52. IADAROLA, M.J. and GALE, K. (1982) Substantia nigra: Site of anticonculsant activity mediated by γ-aminobutyric acid. Sience 218: 1237-1240.
53. ISHIMARU, M., KURUMAJI, A. and TORU, M. (1994) Increases in strychnine-insensitive glycine binding sites in cerebral cortex of chronic schizophrenics: Evidence for glutamate hypothesis. Biol. Psychiatry 35 (2): 84-95.
54. JACOB, H. and BECKMANN, H. (1986) Prenatal development disturbances in the limbic allocortex in schizophrenics. J. Neural. Transm. 65: 303-326.
55. JANOWSKY, D.S., KHALED EL-YOUSEF, M., DAVIS, J.M. and SEKERKE, H.J. (1973) Provocation of schizophrenic symptoms by intravenous administration of methylphenidate. Arch. Gen. Psychiatry 28: 185-1991.
56. JERNIGAN, T.L., ZISOOK, S., HEATON, R.K., MORANVILLE, J.T., HESSELINK, J.R. and BRAFF, D.L. (1991) Magnetic resonance imaging abnormalities in lenticular nuclei and cerebral cortex in schizophrenia. Arch. Gen. Psychiatry 48: 881-90.
57. JOYCE, J.N. (1993) The dopamine hypothesis of schizophrenia: Limbic interactions with serotonin and norepinephrine. Psychopharmacology 112: 16-34.
58. KALIVAS, P.W. and WEBER, B. (1988) Amphetamine injection into the ventral mesencephalon sensitizes rats to peripheral amphetamine og cocaine. J. Pharmacol. Exp. Ther. 245: 1095-1102.
59. KERWIN, R.W., PATEL, S., MELDRUM, B.S., CZUDEK, C. and REYNOLDS, G. (1988) Asymmetrical loss of glutamate receptor subtype in left hippocampus in schizophrenia. Lancet i: 583-584.
60. KERWIN, R.W., PATEL, S. and REYNOLDS, G.P. (1990) Autoradiographic localization of the glutamate receptor system in control and schizophrenic post-mortem hippocampal formation. Neuroscience 39: 25-32.
61. 1. Psychol. Med. 23: 547-551.
62. KRAUS, J.E., YEH, G.C., BONHAUS, D.W., NADLER, J.V. and MCNAMARA, J.O. (1994) Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3. J. Neurosci. 14 (7): 4196-205.
63. KRYSTAL, J.H., KARPER, L.P., SEIBYL, J.P., FREEMAN, G.K., DELANEY, R., BRENNER, J.D., HENINGER, G.R., BOWERS, M.B. and DENNIS, S.C. (1994) Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: Psychotominetic, perceptual, cognitive, and neuroendocrine responses. Arch. Gen. Psychiatry 51: 199-214.
64. LEVY, D.L., SMITH, M., ROBINSON, D., JODY, D. LERNER, G., ALVIR, J., GEISLER, S.H., SZYMANSKI, S.R., GONZALEZ, A., MAYERHOF, D.I., LIEBERMAN, J.A. and MENDELL, N.R. (1993) Methylphenidate increases thought disorder in recent onset schizophrenics, but not in normal controls. Biol. Psychiatry 34: 507-514
65. LIEBERMANN, J.A., KINON, B.J. and LOEBEL, A.D. (1990) Dopaminergic mechanisms in idiopathic and drug-induced pscyhoses. Schizophrenia Bull. 16: 97-110.
66. LIPSKA, B.K., JASKIW, G.E. and WEINBERGER, D.R. (1993) Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: A potential animal model of schizophrenia. Neuropsychopharmacology 9 (1): 67-75.
67. LIPSKA, B.K., JASKIW, G.E. and WEINBERGER, D.R. (1994) The effects of combined prefrontal cortical and hippocampal damage on dopamine-related behaviors in rats. Pharmacol. Biochem. Behav. 48 (4): 1053-1057.
68. LOUILOT, A. and LE MOAL, M. (1994) Lateralized interdependence between limbicotemporal and ventrostriatal dopaminergic transmission. Neuroscience 59 (3): 495-500.
69. LÖSCHER, W. and SCHWARK, W.S. (1985) Evidence for impaired GABAergic activity in the substantia nigra of amygdaloid kindled rats. Brain Res. 339: 146-150.
70. LÖSCHER, W. and SCHWARK, W.S. (1987) Further evidence for abnormal GABAergic circuits in amygdala-kindled rats. Brain. Res. 420: 385-390.
71. 76Br]bromospiperone in untreated schizophrenic patients. Am. J. Psychiatry 147: 44-50.
72. MCGHIE, A. and CHAPMAN, J. (1961) Disorders of attention and perception in early schizophrenia. Br. J. Med. Psychopharmacolygy 34: 103-117.
73. MENDEZ, M.F., GRAU, R., DOSS, R.C. and TAYLOR, J.L. (1993) Schizophrenia in epilepsy: Seizure and psychosis variables. Neurology 43: 1073-1077.
74. MITTLEMAN, G., LEDUC, P.A. and WHISHAW, I.Q. (1993) The role of D1 and D2 receptors in the heightened locomotion induced by direct and indirect dopamine agonists in rats with hippocampal damage: an animal analogue of schizophrenia. Behav. Brain Res. 55: 253-267.
75. MOGHADDAM, B., GRUEN, R.J., ROTH, R.H., BUNNEY, B.S. and ADAMS, R.N. (1991) Effect of L-glutamate on the release of striatal dopamine: in vivo dialysis and elektrochemical studies. Brain Res. 190:518:
76. MORIMOTO, K. and GODDARD, G.V. (1987) The substantia nigra is an important site for the containment of seizure generalization in the kindling model of epilepsy. Epilepsia 28: 1-10.
77. MURASE, S., GRENHOFF, J., CHOUVET, G., GONON, F.G. and SVENSSON, T.H. (1993) Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo. Neurosci. Lett. 157 (1): 53-6.
78. NEDIVI, E., HEVRONI, D., NAOT, D., ISRAEL, D. and CITRI, Y. (1993) Numerous candidate plasticity-related genes revealed by differential cDNA cloning. Nature 363: 718-723.
79. 2 receptor agonists in Cebus apella monkeys previously treated with halloperidol. Eur. J. Pharmacol. 237: 329-340.
80. PIJNENBURG, A.J.J., HONIG, W.M.M., VAN ROSSUM, J.M. (1975) Inhibition of d-amphetamine induced locomotor activity by injection of haloperidol into nucleus accumbens of the rat. Psychopharmacologia 41: 87-95.
81. PILOVSKY, L.S., COSTA, D.C., ELL, P.J., VERHOEFF, N.P.L.G., MURRAY, R.M. and KERWIN, R.W. (1994) D2 dopamine receptor binding in the basal ganglia of antipsychotic-free schisophrenic patients. An 123I-IBZM single photon emission computerised tomography study. 164: 16-26.
82. PRALONG, E. and JONES, R.S. (1993) Interactions of dopamine with glutamate-and GABA-mediated synaptic transmission in the rat entorhinal cortex in vitro. Eur. J. Nerurosci. 5 (6): 760-767.
83. REIMER, A.R. and MARTIN-IVERSON, M.T. (1994) Nimodipine and haloperidol attenuate behavioural sensitization to cocaine but only nimodipine blocks the etablishment of conditioned locomotion induced cocaine. Psychopharmacology 113: 404-410.
84. REITH, J., BENKELFAT, C., SHERWIN, YASUHARA, Y., KUWABARA, H., ANDERMANN, F., BACHNEFF, S., CUMMING, P., DIKSIC, M., DYVE, S.E., ETIENNE, P., EVANS, A.C., LAL, S., SHEVELL, M., SAVARD, G., WONG, D.F., CHOUINARD, G. and GJEDDE, A. (1994) Elevated dopa decarboxylase activity in living brain of patients with psychosis. Neurobiology 91: 11651-11654.
85. REYNOLDS, G.P., CZUDEK, C. and ANDREWS, H.B. (1990) Deficit and hemispheric asymmetry of GABA uptake sites in the hippocampus in schizophrenia. Biol. Pscyhiatry 27: 1038-1044.
86. ROBINSON, T.E. and BECKER, J.B. (1986) Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis. Brain. Res. Rev. 11: 157-198.
87. RUBIN, P., HEMMINGSEN, R., HOLM, S., MØLLER-MADSEN, S., HERTEL, C., POVLSEN, J. and KARLE, A. (1994) Relationship between brain structure and function in disorders of the schizophrenic spectrum: SPECT, CT and psychopathology of first episodes. Acta Psychiatr. Scand. 90: 281-289.
88. SATO, M., NUMACHI, Y. and HAMAMURA, T. (1992). Relapse of paranoid psychotic state in methamphetamine model of schizophrenia. Schizophr. Bull. 18 (1): 115-121.
89. SCHEEL-KRÜGER, J. and WILLNER, P. (1991) The mesolimbic system: Principles of operation. In: The mesolimbic dopamine system: From motivation to action, pp 559-97, P. Willner, J. Scheel-Krüger (Eds.). John Wiley & Sons Ltd.
90. SHIN, C., SILVER, J.M., BONHAUS, D.W. and MCNAMARA, J.O. (1987) The role of substatia nigra in the development of kindling: Pharmacological and lesion studies. Brain Res. 412: 317-7.
91. SIMPSON, M.D.C., ROYSTON, M.C. SLATER, P. and DEAKIN, J.F.W. (1990) Phencyclidine and sigma receptor abnormalities in schizophrenic post-mortem brain. Schizophr. Res. 3:32 (Abst. VB2).
92. STEVENS, J.R. and LIVERMORE, A. (1978) Kindling of the mesolimbic dopamine system: Animal model of psychosis. Neurology. 48: 36-46.
93. STRIPLIN, C.D. and KALIVAS, P.W. (1992) Correlation between behavioral sensitization to cocaine and G protein ADP-ribosylation in the ventral tegmental area. Brain Res. 579: 181-186.
94. SVEKSSON, T.H., ENGBERG, G., TUNG, C.-S. and GRENHOFF, J. (1989) Pacemaker-like firing of noradrenergic locus coeruleus neurons in vivo induced by the excitatory amino acid antagonist kynurenate in the rat. Acta Physiol. Scand. 135: 421-422.
95. TURSKI, L., CAVALHEIRO, E.A., SCHWARZ, M., TURSKI, W.A., MELLO, L.E.A.D.M., BORTOLOTTO, Z.A., KLOCKGETHER, T. and SONTAG, K.-H. (1986) Susceptibility to seizure produced by pilocarpine in rats after microinjection of isoniazid or γ-vinyl-GABA into the substantia nigra. Brain Res. 370: 294-106.
96. ULAS, J. NGUYEN, E. and COTMAN, C.W. (1993) Chronic haloperidol treatment enhances binding to NMDA receptors in rat cortex. NeuroReport 4: 1049-1051.
97. UTENA, H. (1966) Behavioral aberrations in methamphetamine intoxicated animals and chemical correlates in the brain. In: T. Tokizane and J.P. Schade (Eds.), Progress in Brain Research. 21 B, Correlative Neurosciences: Clinical Studies, Elsevier, Amsterdam, pp 192-207.
98. UTENA, H., MACHIYAMA, Y., HSU, S.C., KATAGIRI, M. and HIRATA, A. (1975) A monkey model for schizophrenia produced by methamphetamine. In: Contempory Primatology, S. Kondo, M. Kawai and A. Ehara (Eds.), Karger, Basel, pp 502-507.
99. WEISS, F., PAULUS, M.P., LORANG, M.T. and KOOB, G.F. (1992) Increases in Extracellular Doparnine in the Nucleus Accumbens by Cocaine Are Iversely Related to Basal Levels: Effects of Acute and Repeated Administration. J. Neurosci. 12 (11): 4372-4380.
100. WEISSMANN, A.D., CASANOVA, M.F., KLEINMANN, J.E., LONDON, E. and DESOUZA, E.B. (1991) Selective losses of cerebral cortical sigma but not PCP binding sites in schizophrenia. Biol. Psychiatry 29: 41-54.
101. WONG, D.F., WAGNER, H.N., TUNE, L.E., DANNALS, R.F., PEARLSSON, G.D., LINKS, J.M., TAMINGA, C.A., BROUSSOLEE, E.P., RAVERT, H.T., WILSON, A.A., TOUNG, J.K.T., MALAT, J., WILLIAMS, F.A., O'TOUMA, L.A., SNYDER, S.H., KUHAR, M.J. and GJEDDE, A. (1986) Positron emission tomography reveals elevated D2 dopamine receptors in drugnaive schizophrenics. Science 234: 1558-1563.
102. YEH, G.C., BONHAUS, D.W., NADLER, J.V. and MACNAMARA, J.O. (1989) N-methyl-D-aspartate receptor plasticity in kindling: quantitative-qualitative alterrations in N-methyl-D-aspartate receptor complex. Proc. Natl. Acad. Sci. USA 86: 8157-8160.
103. YAMAMOTO, B.K. and COOPERMAN, M.A. (1994) Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations. J. Neurosci. 14 (7): 4159-66.