Homozygosity for a common polymorphism in the islet-specific promoter of the glucokinase gene is associated with a reduced early insulin response to oral glucose in pregnant women

Diabetic Medicine

Volumn 14, Issue 3, 1997, Pages 228-234

  Zaidi, F K ^a   Wareham, N J ^a   McCarthy, M I ^b,c   Holdstock, J ^a   Kalloo Hosein, H ^a   Krook, A ^a   Swinn, R A ^a   O'Rahilly, S ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ROYAL LONDON HOSPITAL   (United Kingdom)

^c ST MARY S HOSPITAL   (United Kingdom)

Author keywords

gestational diabetes; glucokinase; glucose intolerance; insulin secretion; molecular scanning

Indexed keywords

GLUCOKINASE; GLUCOSE;

ADULT; ARTICLE; FEMALE; GENETIC POLYMORPHISM; GLUCOSE INTOLERANCE; HOMOZYGOSITY; HUMAN; INSULIN RELEASE; INSULIN RESPONSE; MAJOR CLINICAL STUDY; MUTATION; PREGNANCY DIABETES MELLITUS;

BASE SEQUENCE; BLOOD GLUCOSE; DIABETES, GESTATIONAL; EUROPEAN CONTINENTAL ANCESTRY GROUP; EXONS; FEMALE; GLUCOKINASE; GLUCOSE TOLERANCE TEST; GREAT BRITAIN; HETEROZYGOTE DETECTION; HOMOZYGOTE; HUMANS; INSULIN; ISLETS OF LANGERHANS; LIVER; POLYMORPHISM, GENETIC; PREGNANCY; PROMOTER REGIONS (GENETICS); VARIATION (GENETICS);

EID: 0030948233     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9136(199703)14:3<228::AID-DIA330>3.0.CO;2-N     Document Type: Article

References (26)

1. Kühl C. Insulin secretion and insulin resistance in pregnancy and GDM. Implications for diagnosis and management. Diabetes 1991; 40 (suppl 2): 18-24.
2. Dornhorst A, Beard RW. Gestational diabetes: a challenge for the future. Diabetic Med 1993; 10: 897-905.
3. Kühl C, Hornnes PJ, Andersen O. Etiology and pathophysiology of gestational diabetes mellitus. Diabetes 1985; 34: 66-70.
4. Byrne M, Sturis J, Clement K, Velho G, Frougel P, Bell GI, Polonsky K. Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations. J Clin Invest 1994; 93: 1120-1130.
5. Froguel P, Zouali H, Vionnet N, Velho G. Familial hyperglycemia due to mutation in glucokinase. New Engl J Med 1993; 328: 697-702.
6. Stoffel M, Patel P, Lo YD, Hattersley A, Turner RC, Bell GI. Missense glucokinase mutation in maturity-onset diabetes of the young and mutation screening in late-onset diabetes. Nature Genetics 1992; 2: 153-156.
7. Chiu KA, Go RCP, Aoki M, Permutt MA. Glucokinase gene in gestational diabetes mellitus: population association study and molecular scanning. Diabetologia 1994; 37: 104-110.
8. Stoffel M, Bell KL, Blackburn CL, Powell KL, Seo TS, Takeda J, Bell GI. Identification of glucokinase mutations in subjects with gestational diabetes mellitus. Diabetes 1993; 42: 937-940.
9. Saker PJ, Hattersley A, Barrow B, McLellan J-A, Lo Y-MD, Olds RJ, et al. Mutations in the glucokinase gene contribute to the pathogenesis of gestational diabetes (Abstract). Diabetologia 1994; 37: A17.
10. Matsutani A, Noda K, Tao T, Tanizawa Y, Kaneko T, Kaku K. Variation of promoter activity of glucokinase gene in human. Diabetes 1993; 42: 94A.
11. Shimokawa K, Sakura H, Otabe S, Eto K, Kadowaki H, Hagura R, et al. Analysis of the glucokinase gene promoter in Japanese subjects with noninsulin-dependent diabetes mellitus. J Clin Endocrin Metab 1994; 79: 883-886.
12. Stone LM, Kahn SE, Fujimoto WY, Deeb SS, Porte D Jr. A variation at position -30 of the β-cell glucokinase gene promoter polymorphism is associated with reduced β-cell function in middle-aged Japanese-American men. Diabetes 1996; 45: 422-428.
13. Pettit DJ, Knowler WC, Baird HR, Bennett PH. Gestational diabetes: infant and maternal complications of pregnancy in relation to third trimester glucose tolerance in Pima Indians. Diabetes Care 1980; 3: 458-64.
14. Zouali H, Vaxillaire M, Lesage S, et al. Linkage analysis and molecular scanning of the glucokinase gene in NIDDM families. Diabetes 1993; 42: 1238-1245.
15. Eto K, Sakura H, Shimokawa K, Hadowani H, Halura R, Akanuma Y et al. Sequence variations of the glucokinase gene in Japanese subjects with NIDDM. Diabetes 1993; 42: 1133-1137.
16. Sheffield VC, Beck JS, Kwitek AE, Sandstrom DW, Stone EM. The sensitivity of single-strain conformation polymorphism analysis for the detection of single base substitutions. Cenomics 1993; 16: 325-332.
17. Temple RC, Luzio SD, Schneider AE, Carrington A, Owens DR, Sobey WJ, Hales CN. Insulin deficiency in non-insulin dependent diabetes. Lancet 1989; 2: 293-295.
18. Davies MJ, Rayman G, Gray IP, Day JL, Hales CN. Insulin deficiency and increased plasma concentration of intact and 32/33 split proinsulin in subjects with impaired glucose tolerance. Diabetic Med 1993; 10: 313-320.
19. Phillips DIW, Clark PN, Hales CN, Osmond C. Understanding oral glucose tolerance: comparison of glucose or insulin measurement during the oral glucose tolerance test with specific measurements of insulin resistance or insulin secretion. Diabetic Med 1994; 11: 286-292.
20. Wareham NJ, Phillips DIW, Byrne CD, Hales CN. The 30 minute insulin incremental response in an oral glucose tolerance test as a measure of insulin secretion. Diabetic Med 1995; 12: 931.
21. Magnuson MA, Glukokinase gene structure: functional implication of molecular genetic studies. Diabetes 1990; 39: 523-527.
22. Takeda J, Gidh Jain M, Liang-Zhong X, Froguel P, Velho G, Vaxillaine M, et al. Structure/function studies of human-cell glucokinase: enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants. J Biol Chem 1993; 268: 15200-15204.
23. Fujimoto WY, Leonetti DL, Kinyoun JL, Newell-Morris L, Shuman WP, Stolov WC, Wahl PW. Prevalence of diabetes mellitus and impaired glucose tolerance in second generation Japanese - American men. Diabetes 1987; 36: 721-729.
24. Turner RC, Hattersley AT, Shaw JTE, Levy JC. Type II diabetes: clinical aspects of molecular biological studies. Diabetes 1995; 44: 1-10.
25. De Fronzo RA. The triumvirate; β-cell, muscle and liver: a collusion responsible for NIDDM. Diabetes 1988; 37: 667-687.
26. Tanizawa Y, Matsutani A, Chiu KC, Permutt MA. Human glucokinase gene: isolation, structural characterization, and identification of a microsatellite repeat polymorphism. Molec Endocrinol 1992; 6: 1070-1081.