Safety and efficacy of monotherapy with fantofarone, a novel calcium channel antagonist, in patients with chronic stable angina pectoris

Journal of Clinical Pharmacology

Volumn 37, Issue 1, 1997, Pages 53-57

  Glasser, Stephen P ^a,d   Singh, Steven N ^b   Humen, Dennis P ^c  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; FANTOFARONE;

ADULT; AGED; ANGINA PECTORIS; ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; SINUS BRADYCARDIA; SYSTOLIC BLOOD PRESSURE; TREADMILL EXERCISE;

EID: 0030948118     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/009127009703700109     Document Type: Article

References (5)

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2. Nokin P, Clinet M, Beaufort P, Meysmans L, Laurel R, Chatelain P: SR 3357, a novel calcium entry blocker: II. Interactions with 1,4 dihydropyridine, phenylalkamine and benzothiazepine binding sites in rat heart sarcolemmal membranes. J Pharmacol Exp Ther 1990;255:600-607.
3. ++ channels: identification of receptor sites and analysis of its mode of action. Mol Pharmacol 1989;35:766-773.
4. Frishman W, Pepine C, Weiss R, Baiker W: Addition of zatebradine, a direct sinus node inhibitor, provides no greater exercise tolerance benefit in patients with angina taking extended-release nifedipine: results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group study. J Am Coll Cardiol 1995;26:305-312.
5. Classer S, Michie D, Thadani U, Baiker WM: Selective reduction in heart rate with the sinus node inhibitor zatebradine does not lead to the expected improvements in exercise duration in patients with angina pectoris (abstract). J Am Coll Cardiol 1995;25:127A.