Usefulness of moexipril and hydrochlorothiazide in moderately severe essential hypertension

American Journal of Therapeutics

Volumn 4, Issue 4, 1997, Pages 123-129

  White, William B ^a,c   Koch, Brigette ^b   Stimpel, Michael ^b  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b Schwarz Pharma AG   (Germany)

^c UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

Author keywords

Angiotensin converting enzyme inhibitors; Combination therapy; Diuretics; Hydrochlorothiazide; Moexipril; Renin angiotensin system

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROCHLOROTHIAZIDE; MOEXIPRIL; THIAZIDE DIURETIC AGENT;

ADULT; AGED; ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DIASTOLIC BLOOD PRESSURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; ESSENTIAL HYPERTENSION; FEMALE; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; VERTIGO;

EID: 0030947681     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/00045391-199704000-00003     Document Type: Article

References (12)

1. Wing LI, Chalmers J, West M, et al.: Treatment of hypertension with enalapril and hydrochlorothiazide or enalapril and atenolol: contrast in hypotensive reactions. J Hypertens 1987;5:603-609.
2. Kayanakis J, Baulac L: Comparative study of once daily administration of captopril 50 mg, hydrochlorothiazide 25 mg and their combination in mild to moderate hypertension. Br J Clin Pharmacol 1987;23:89-93.
3. Veterans Administration Cooperative Study Group on Antihypertensive Agents: Low-dose captopril for the treatment of mild to moderate hypertension: I. Results of a 14-week trial. Arch Intern Med 1984;144:1947-1953.
4. White WB, Whelton A, Fox AL, Stimpel M, Kaihlanen PM: Tricenter assessment of the efficacy of the ACE inhibitor, moexipril, by ambulatory blood pressure monitoring. J Clin Pharmacol 1995;35:233-238.
5. White WB, Fox AL, Stimpel M: Long-term efficacy and safety of moexipril in the treatment of hypertension. J Hum Hypertens 1994;8:917-921.
6. Dickstein K, Aarsland T, Ferrari P, Todd M, Stimpel M: Comparison of the efficacy of three dose levels of moexipril versus placebo as add-on therapy to hydrochlorothiazide in patients with moderate hypertension. J Cardiovasc Pharmacol 1994;24:247-255.
7. Drayer JIM, Stimpel M, Fox A, Weber M: The antihypertensive properties of the angiotensin-converting enzyme inhibitor moexipril given alone or in combination with a low dose of a diuretic. Am J Therapeutics 1995;2:525-531.
8. SAS/STAT User's Guide, Version 6, 4th ed. SAS Institute, Inc., Cary, NC, 1989.
9. Department of Health and Human Services, Food and Drug Administration. COSTART, 2nd ed., 1985.
10. Pordy RC: Cilazapril plus hydrochlorothiazide: Improved efficacy without reduced safety in mild to moderate hypertension. Cardiology 1994;85:311-322.
11. Lenz T, Schulte KL, Wagner B, Lilienthal J, Gotzen R: Quinapril, hydrochlorothiazide, and combination in patients with moderate to severe hypertension. Eur Heart J 1994;15:940-946.
12. White WB, Stimpel M: Long-term safety and efficacy of moexipril alone and in combination with hydrochlorothiazide in elderly patients with hypertension. J Hum Hypertens 1995;9:879-884.