Reduction in external K causes increased action potential shortening in ventricular myocytes from the spontaneously hypertensive rat

Journal of Hypertension

Volumn 15, Issue 6, 1997, Pages 659-666

  Evans, Stephen J ^a,b   Jones, John V ^a   Levi, Allan J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b BRISTOL ROYAL INFIRMARY   (United Kingdom)

Author keywords

Action potential; Arrhythmia; Left ventricular hypertrophy; Potassium; Spontaneously hypertensive rat

Indexed keywords

MAGNESIUM ION; POTASSIUM ION;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EXCITATION; HEART ARRHYTHMIA; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE CELL; HEART VENTRICLE WALL; HYPERTENSION; MALE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; REPOLARIZATION; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 0030947373     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Bayes de Luna A, Coumel P, Leclercq J: Ambulatory sudden cardiac death: Mechanisms of production of fatal arrhythmia on the basis of data from 157 cases. Am Heart J 1989, 117:151-159.
2. Ghali JK, Kadakia S, Cooper RS, Liao Y: Impact of left ventricular hypertrophy on ventricular arrhythmias in the absence of coronary artery disease. J Am Coll Cardiol 1991, 17:1277-1282.
3. Cohen JD, Neaton JD, Prineas RJ, Daniels KA: Diuretics, serum potassium and ventricular arrhythmias in the multiple risk factor intervention trial. Am J Cardiol 1987, 60:548-554.
4. Dahlof B, Lindholm LH, Hansson L, Schersten B, Ekbom T, Wester PO: Morbidity and mortality in the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension). Lancet 1991, 338:1281-1285.
5. Kannel WB, Cupples LA, D'Agostino RB, Stokes J III: Hypertension, antihypertensive treatment, and sudden coronary death. The Framingham Study. Hypertension 1988, 11:1145-1150.
6. Olsson G, Tuomilehto J, Berglund G, et al.: Primary prevention of sudden cardiovascular death in hypertensive patients. Mortality results from the MAPHY Study. Am J Hypertens 1991, 4:151-158.
7. Hollifield JW: Thiazide treatment of systemic hypertension: effects on serum magnesium and ventricular ectopic activity. Am J Cardiol 1989, 63:22G-25G.
8. Ryan MP: The effects of diuretics on magnesium and potassium homeostasis. In Magnesium in Health and Disease. Edited by Itokawa Y, Durlach J. Paris: John Libbey and Co. Ltd; 1989:397-408.
9. James MA, Jones JV: The paradoxical role of left ventricular hypertrophy in wall stress-related arrhythmia. J Hypertens 1992, 10:167-172.
10. Evans SJ, Levi AJ, Jones JV: Wall stress induced arrhythmia is enhanced by low potassium and early left ventricular hypertrophy in the working rat heart. Cardiovasc Res 1995, 29:555-562.
11. Ten Eick RE, Whalley DW, Rasmussen HH: Connections: Heart disease, cellular electrophysiology, and ion channels. FASEB J 1992, 6:2568-2580.
12. Hart G: Cellular electrophysiology in cardiac hypertrophy and failure. Cardiovasc Res 1994, 28:933-946.
13. Benitah JP, Gomez AM, Bailly P, et al.: Heterogeneity of the early outward current in ventricular cells isolated from normal and hypertrophied rat hearts. J Physiol 1993, 469:111-138.
14. Cerbai E, Barbieri M, Li Q, Mugelli A: Ionic basis of action potential prolongation of hypertrophied cardiac myocytes isolated from hypertensive rats of different ages. Cardiovasc Res 1994, 28:1180-1187.
15. Brooksby P, Levi AJ, Jones JV: The electrophysiological characteristics of hypertrophied ventricular myocytes from the spontaneously hypertensive rat. J Hypertens 1993, 11:611-622.
16. + currents in isolated human ventricular myocytes from patients with terminal heart failure. Circ Res 1993, 73:379-385.
17. + channels are altered in hypertrophied ventricular myocytes. Am J Physiol 1988, 255:H1254-H1258.
18. Engelmann GL, Vitullo JC, Gerrity RG: Morphometric analysis of cardiac hypertrophy during development, maturation, and senescence in spontaneously hypertensive rats. Circ Res 1987, 60:487-494.
19. Bing OHL, Brooks WW, Conrad CH, Sen S, Perreault CL, Morgan JP: Intracellular calcium transients in myocardium from spontaneously hypertensive rats during the transition to heart failure. Circ Res 1991, 68:1390-1400.
20. Levi AJ: The effect of strophanthidin on action potential, calcium current and contraction in isolated guinea-pig ventricular myocytes. J Physiol 1991, 443:1-23.
21. Isenberg G, Klockner U: Calcium tolerant ventricular myocytes prepared by preincubation in a 'KB medium'. Pflügers Arch 1982, 395:6-18.
22. Neher E: Correction for liquid junction potentials in patch clamp experiments. Meth Enzymol 1992, 207:123-131.
23. Cohen CJ, Bean BP, Tsien RW: Maximal upstroke velocity as an index of available sodium conductance. Comparison of maximal upstroke velocity and voltage clamp measurements of sodium current in rabbit Purkinje fibers. Circ Res 1984, 54:636-651.
24. Belichard P, Pruneau D, Brown NL, Salzmann JL, Rouet R: Cardiac hypertrophy and arrhythmias: two possible origins. Arch Mal Cœur 1989, 82:1303-1308.
25. Aronson RS: Characteristics of action potentials of hypertrophied myocardium from rats with renal hypertension. Circ Res 1980, 47:443-454.
26. Ryder KO, Bryant SM, Hart G: Membrane current changes in left ventricular myocytes isolated from guina pigs after abdominal aortic coarctation. Cardiovasc Res 1993, 27:1278-1287.
27. Kleiman RB, Houser SR: Outward currents in normal and hypertrophied feline ventricular myocytes. Am J Physiol 1989, 256:H1450-H1461.
28. Cerbai E, Barbieri M, Li Q, Mugelli A: Cellular electrophysiological alterations induced by hypertrophy: a patch-clamp study in left ventricular myocytes of spontaneously hypertensive rats [abstract]. International Union of Physiological Sciences 1993, 139.69/ P:202.
29. Chatelain P, Demol D, Roba J: Comparison of (3H)nitrendipine binding to heart membranes of normotensive and spontaneously hypertensive rats. J Cardiovasc Pharmacol 1984, 6:220-223.
30. Kimura J, Miyamae S, Noma A: Identification of sodium-calcium exchange current in single ventricular cells of guinea-pig. J Physiol 1987, 384:199-222.
31. Bridge JHB, Smolley JR, Spitzer KW, Chin TK: Voltage dependence of sodium-calcium exchange and the control of calcium extrusion in the heart. Ann NY Acad Sci 1991, 639:34-47.
32. DuBell WH, Boyett MR, Spurgeon HA, Talo A, Stern MD, Lakatta EG: The cytosolic calcium transient modulates the action potential of rat ventricular myocytes. J Physiol 1991,. 436:347-369.
33. Altura BM, Barbour RL, Dowd TL, Wu F, Altura BT, Gupta RK: Low extracellular magnesium induces intracellular free Mg deficits, ischemia, depletion of high-energy phosphates and cardiac failure in intact working rat hearts: a 31P-NMR study. Biochim Biophys Acta 1993, 1182:329-332.
34. Agus ZS, Morad M: Modulation of cardiac ion channels by magnesium. Annu Rev Physiol 1991, 53:299-307.
35. Dichtl A, Vierling W: Inhibition by magnesium of calcium inward current in heart ventricular muscle. Eur J Pharmacol 1991, 204:243-248.
36. Hartzell HC, White RE: Effects of magnesium on inactivation of the voltage-gated calcium current in cardiac myocytes. J Gen Physiol 1989, 94:745-767.
37. Hall SK, Fry CH: Magnesium affects excitation, conduction, and contraction of isolated mammalian cardiac muscle. Am J Physiol 1992, 263:H622-H633.
38. 2+ current. Circ Res 1989, 64:977-990.
39. Aronson R: After potentials and triggered activity in hypertrophied myocardium from rats with renal hypertension. Circ Res 1981, 48:720-727.
40. James MA, Jones JV: Ventricular arrhythmia in untreated newly presenting hypertensive patients compared with a matched normal population. J Hypertens 1989, 7:409-415.
41. Multiple risk factor intervention trial research group. Baseline rest electrocardiographic abnormalities, antihypertensive treatment, and mortality in the multiple risk factor intervention trial. Am J Cardiol 1985, 55: 1-15.
42. Siegel D, Hulley SB, Black DM, et al.: Diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men. JAMA 1992, 267:1083-1089.
43. Frewin DB, Bartholomeusz RC, Gaffney RD, Clampett AD, Chatterton BE: A comparison of the effect of lisinopril and hydrochlorothiazide on electrolyte balance in essential hypertension. Eur J Clin Pharmacol 1992, 42:487-490.
44. Hollifield JW: Thiazide treatment of hypertension. Effects of thiazide diuretics on serum potassium, magnesium, and ventricular ectopy. Am J Med 1986, 80:8-12.
45. Knochel JP: Role of glucoregulatory hormones in potassium homeostasis. Kidney Int 1977, 11:443-452.
46. Beuckelmann DJ, Nabauer M, Erdmann E: Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure. Circulation 1992, 85:1046-1055.
47. Savage DD, Drayer JI, Henry WL: Echocardiographic assessment of cardiac anatomy and function in hypertensive subjects. Circulation 1979, 59:623-632.
48. Savage DD, Garrison RJ, Kannel WB, et al.: The spectrum of left ventricular hypertrophy in a general population sample: the Framingham study. Circulation 1987, 75:126-133.
49. Korner P, Bobik A, Oddie C, Friberg P: Sympathoadrenal system is critical for structural changes in genetic hypertension. Hypertension 1993, 22:243-252.