Morphine tolerance and dependence in the rat intestine in vivo

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 2, 1997, Pages 656-663

  Williams, Cynthia L ^a   Bihm, Cynthia C ^a   Rosenfeld, Gary C ^a   Burks, Thomas F ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE; NALOXONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BOLUS INJECTION; CONTINUOUS INFUSION; CONTROLLED STUDY; DIARRHEA; INTESTINE CONTRACTION; INTESTINE MOTILITY; INTESTINE TRANSIT TIME; MALE; MORPHINE ADDICTION; MORPHINE TOLERANCE; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; WITHDRAWAL SYNDROME;

ANIMALS; COLON; DRUG TOLERANCE; DUODENUM; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRANSIT; INFUSIONS, PARENTERAL; INJECTIONS, SUBCUTANEOUS; MALE; MORPHINE; MORPHINE DEPENDENCE; MUSCLE, SMOOTH; NALOXONE; PAIN; RATS; RATS, SPRAGUE-DAWLEY; STEREOTYPED BEHAVIOR;

EID: 0030946385     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. BROWN, N. J., COUPAR, I. M. AND RUMSEY, D. E.: The effects of acute and chronic administration of morphine and morphine withdrawal on intestinal transit time in the rat. J. Pharm. Pharmacol. 40: 844-848, 1988.
2. BURKS, T. F., CASTRO, G. A. AND WEISBRODT, N. W.: Tolerance to intestinal stimulatory actions of morphine. In Opiates and Endogenous Opioid Peptides, ed. by H. W. Kosterlitz, pp. 369-376, Elsevier Biomedical Press, Amsterdam, 1976.
3. BURKS, T. F. AND GRUBB, M. N.: Sites of acute morphine tolerance in the intestine. J. Pharmacol. Exp. Ther. 191: 518-526, 1974.
4. BURKS, T. F., JAQUETTE, D. L. AND GRUBB, M. N.: Development of tolerance to the stimulatory effect of morphine in dog intestine. Eur. J. Pharmacol. 26: 302-308, 1974.
5. BURLEIGH, D. E., GALLICAN, J. J. AND BURKS, T. F.: Subcutaneous morphine reduces intestinal propulsion in rats partly by a central action. Eur. J. Pharmacol. 75: 283-287, 1981.
6. COLLIER, H. O. J., FRANCIS, D. L. AND SCHNEIDER, C.: Modification of morphine withdrawal by drugs interacting with humoral mechanisms: Some contradictions and their interpretation. Nature (Lond.) 237: 220-223, 1972.
7. KUPERMAN, D. A., SNINSKY, C. A. AND LYNCH, D. F.: Myoelectric activity of the small intestine during morphine dependence and withdrawal in rats. Am. J. Physiol. 252: G562-G567, 1987.
8. LING, G. S. F., PAUL, D., SIMANTOV, R. AND PASTERNAK, G. W.: Differential development of acute tolerance to analgesia, respiratory depression, gastrointestinal transit, and hormone release in a morphine infusion model. Life Sci. 45: 1627-1636, 1989.
9. LUX, B. AND SCHULTZ, R.: Effect of cholera toxin and pertussis toxin on opioid tolerance and dependence in the guinea pig myenteric plexus. J. Pharmacol. Exp. Ther. 237: 995-1000, 1986.
10. MANARA, L., BIANCHI, G., FERRETI, P., MONIFERINI, E., STRADA, D. AND TAVANI, A.: Local and CNS-mediated effects of morphine and narcotic antagonists on gastrointestinal propulsion in rats. In Endogenous and Exogenous Opiate Agonists and Antagonists, ed. by E. L. Way, pp. 143-146, Pergamon Press, New York, 1976.
11. MARGARITIS, J., COUPAR, I. M. AND BENTLEY, G. A.: Studies to determine whether there is tolerance or cross-tolerance to the anti-secretory effect of morphine and clonidine in the rat intestine. J. Pharm. Pharmacol. 43: 655-658, 1993.
12. MILLER, G. H. AND PLANT, O. H.: Effect of morphine and some other opium alkaloids on the muscular activity of the alimentary canal. J. Pharmacol. Exp. Ther. 28: 241-249, 1926.
13. MILLER, S., GALLIGAN, J. J. AND BURKS, T. F.: Accurate measurement of intestinal transit in the rat. J. Pharmacol. Methods 6: 211-217, 1981.
14. PORRECA F., MOSBERG, H. I., HURST, R., HRUBY, V. J. AND BURKS, T. F.: Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse. J. Pharmacol. Exp. Ther. 230: 341-348, 1984.
15. REISINE, T. AND PASTERNAK, G.: Opioid analgesics and antagonists. In Goodman and Gilman's The Pharmacological Basis of Therapeutics, ed. by J. G. Hardman, L. E. Limbird, P. M. Molinoff, R. W. Ruddon and A. Goodman Gilman, 521-555, McGraw-Hill Publishing Co., New York, 1996.
16. REZVANI, A., HUIDOBRO-TORO, J. P., HU, J. AND WAY, E. L.: A rapid and simple method for the quantitative determination of tolerance development to opiates in the guinea pig ileum in vitro. J. Pharmacol. Exp. Ther. 225: 251-255, 1983.
17. SCHULZ, R., SEIDL, E., WUSTER, M. AND HERZ, A.: Opioid dependence and cross-dependence in the isolated guinea pig ileum. Eur. J. Pharmacol. 84: 33-40, 1982.
18. TALLARIDA, R. J. AND MURRAY, R. B.: Manual of Pharmacologic Calculations with Computer Programs, Springer-Verlag, New York, 1987.
19. VINAYEK, R., BROWN, D. R. AND MILLER, R. J.: Tolerance and cross tolerance to the antisecretory effects of enkephalins in the guinea pig ileal mucosa. J. Pharmacol. Exp. Ther. 232: 781-785, 1985.
20. WARHURST, G., SMITH, G. S., HIGGS, N., TONGE, A. AND TURNBERG, L. A.: Influence of morphine tolerance and withdrawal on intestinal salt and water transport in the rat in vivo and in vitro. Gastroenterology 87: 1035-1041, 1984.
21. WAY, E. L.: Opioid tolerance and dependence and their relationship. In Opioids II, ed. by A. Herz, pp. 573-596, Springer Verlag, New York, 1993.
22. WEI, E. T.: Enkephalin analogs and physical dependence. J. Pharmacol. Exp. Ther. 216: 12-18, 1981.
23. WEISBRODT, N. W., BADIAL-ACEVES, F., DUDRICK, S. J., BURKS, T. F. AND CASTRO, G. A.: Tolerance to the effect of morphine on intestinal transit. Proc. Soc. Exp. Biol. Med. 154: 587-590, 1977.
24. WEISBRODT, N. W., THOR, P. J., COPELAND, E. M. AND BURKS, T. F.: Tolerance to the effects of morphine on intestinal motility of unanesthetized dogs, J. Pharmacol. Exp. Ther. 215: 515-521, 1980.