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Volumn 47, Issue 2, 1997, Pages 169-174
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Pharmacokinetics of (±)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate. 3rd Communication: Plasma concentrations of the unchanged drug and its deethylated metabolite in rats, dogs and monkeys
a
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Author keywords
( ) 4 diethylamino 1,1 dimethylbut 2 yn 1 yl 2 cyclohexyl 2 hydroxy 2 phenylacetate monohydrochloride monohydrate; anticholinergic drugs, with calcium antagonistic activity; CAS 129927 33 4; NS 21 enantiomer, first pass effect, metabolism, protein binding
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Indexed keywords
2 CYCLOHEXYL 2 HYDROXY 2 PHENYLACETIC ACID 4 ETHYLAMINO 1,1 DIMETHYL 2 BUTYNYL ESTER;
CALCIUM ANTAGONIST;
CHOLINERGIC RECEPTOR BLOCKING AGENT;
DRUG METABOLITE;
HUMAN SERUM ALBUMIN;
OROSOMUCOID;
RADIOISOTOPE;
TEMIVERINE;
UNCLASSIFIED DRUG;
ANTIHYPERTENSIVE AGENT;
CALCIUM CHANNEL BLOCKING AGENT;
PHENYLACETIC ACID DERIVATIVE;
PLASMA PROTEIN;
ANIMAL EXPERIMENT;
ANIMAL TISSUE;
ARTICLE;
BIOTRANSFORMATION;
CONTROLLED STUDY;
DOG;
DRUG BIOAVAILABILITY;
DRUG BLOOD LEVEL;
DRUG DISPOSITION;
DRUG ELIMINATION;
DRUG HALF LIFE;
DRUG PROTEIN BINDING;
HUMAN;
INTRAVENOUS DRUG ADMINISTRATION;
LIVER MICROSOME;
MALE;
MONKEY;
NONHUMAN;
ORAL DRUG ADMINISTRATION;
RAT;
SPECIES DIFFERENCE;
STEREOSPECIFICITY;
ANIMAL;
BLOOD;
COMPARATIVE STUDY;
DEALKYLATION;
HYDROXYLATION;
IN VITRO STUDY;
MACACA;
METABOLISM;
PROTEIN BINDING;
SPRAGUE DAWLEY RAT;
ADMINISTRATION, ORAL;
ANIMALS;
ANTIHYPERTENSIVE AGENTS;
BIOTRANSFORMATION;
BLOOD PROTEINS;
CALCIUM CHANNEL BLOCKERS;
DEALKYLATION;
DOGS;
HYDROXYLATION;
INJECTIONS, INTRAVENOUS;
MACACA FASCICULARIS;
MALE;
MICROSOMES, LIVER;
PHENYLACETATES;
PROTEIN BINDING;
RATS;
RATS, SPRAGUE-DAWLEY;
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EID: 0030946371
PISSN: 00044172
EISSN: None
Source Type: Journal
DOI: None Document Type: Article |
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Times cited : (3)
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References (6)
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