Acute pancreatitis-induced enzyme release and necrosis are attenuated by IL-1 antagonism through an indirect mechanism

Journal of Surgical Research

Volumn 67, Issue 1, 1997, Pages 94-97

  Fink, Gregory ^a   Yang, Jun ^a   Carter, Gay ^a   Norman, James ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLASE; CERULETIDE; COLLAGENASE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; RECOMBINANT INTERLEUKIN 1BETA;

ACINAR CELL; ACUTE HEMORRHAGIC PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME RELEASE; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PANCREAS NECROSIS; PANCREAS SECRETION; PRIORITY JOURNAL; RAT;

EID: 0030946365     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1996.4935     Document Type: Article

References (17)

1. 1. Lowry, S. F. Cytokine mediators of immunity and inflammation. Arch. Surg. 128: 1235-1241, 1993.
2. 2. McKay, C., Gallagher, G., Baxter, J. N., and Imrie, C. W. Systemic complications in acute pancreatitis are associated with increased monocyte cytokine release. Gut 35: A575, 1994.
3. 3. Gross, V., Leser, H. G., Heinisch, A., and Scholmerich, J. Inflammatory mediators and cytokines - New aspects of the pathophysiology and assessment of severity of acute pancreatitis. Hepatogastroenterology 40: 522-530, 1993.
4. 4. McKay, C., Gallagher, G., Baxter, J. N., and Imrie, C. W. Systemic complications in acute pancreatitis are associated with increased monocyte cytosine release. Gut 35: A575, 1994.
5. 5. Norman, J., Franz, M., Riker, A., and Gower, W. R. Rapid elevation of pro-inflammatory cytokines during acute pancreatitis and their origin within the pancreas. Surg. Forum XLV: 148-149, 1994.
6. 6. Norman, J., Fink, G., Franz, M., and Carter, G. Systemic cytokine gene expression induced by acute pancreatitis. Gastroenterology 108: 1236, 1995.
7. 7. Fink, G., and Norman, J., Intrapancreatic interleukin-1β gene expression by specific leukocyte populations during acute pancreatitis. J. Surg. Res. 63: 369-373, 1996.
8. 8. Norman, J., Fink, G., Franz, M., Guffey, J., Carter, G., Davison, B., Sexton, C., and Glaccum, M. Active interleukin-1 receptor required for maximal progression of acute pancreatitis. Ann. Surg. 223: 163-169, 1996.
9. 9. Norman, J., Franz, M., Fink, G., Messina, J., Fabri, P. J., Gower, W. R., and Carey, L. C. Decreased mortality of severe acute pancreatitis following proximal cytokine blockade. Ann. Surg. 221: 453-460, 1995.
10. 10. Tanaka, N., Murata, A., Uda, K., Toda, H., et al. Interleukin-1 receptor antagonist modifies the changes in vital organs induced by acute necrotizing pancreatitis in a rat experimental model. Crit. Care Med. 23: 901-908, 1995.
11. 11. Norman, J., Fink, G., and Franz, M. Acute pancreatitis induces intrapancreatic tumor necrosis factor gene expression. Arch. Surg. 130: 966-970, 1995.
12. 12. Tani, S., Otsuki, M., Itoh, H., Fujii, M., Nakamura, T., Oka, T., and Baba, S. Histologic and biochemical alterations in experimental acute pancreatitis induced by supramaximal caerulien stimulation. Int. J. Pancreatol. 2: 337-348, 1987.
13. 13. Bruzzone, R., Halban, P., Gjinovci, A., and Trimble, E. A new, rapid, method for preparation of dispersed pancreatic acini. Biochem. J. 226: 621-624, 1985.
14. 14. Leach, S. D., Modlin, I. M., Scheele, G. A., and Gorelick, F. S. Intracellular activation of digestive zymogens in rat pancreatic acini - Stimulation by high doses of cholecystokinin. J. Clin. Invest. 87: 362-366, 1991.
15. 15. Dinarello, C. The interleukin-1 family: 10 years of discovery. FASEB J. 8: 1314-1325, 1994.
16. 16. Granowitz, E. V., Clark, B. D., Vannier, E., Callahan, M. V., and Dinarello, C. A. Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: IL-1 receptor antagonist inhibits IL-1-induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor on human monocytes. Blood 79: 2356-2363, 1992.
17. 17. Ikejima, T., Okusawa, S., Ghezzi, P., van der Meer, J. W. M., and Dinarello, C. A. Interleukin-1 induces tumor necrosis factor in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits. J. Infect. Dis. 162: 215-220, 1990.