Lesions of regions for in vitro ventilatory genesis eliminate gasping but not eupnea

Respiration Physiology

Volumn 107, Issue 2, 1997, Pages 111-123

  Huang, Qin ^a   Zhou, Dan ^a   St John, Walter M ^a  

^a DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

Author keywords

control of breathing; eupnea; gasping; kainic acid; mammals; neonatal; pattern of breathing; pharmacological agents; rat; rhythmogenesis

Indexed keywords

KAINIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREATHING PATTERN; CONTROLLED STUDY; IN VITRO STUDY; LUNG VENTILATION; MAMMAL; MEDULLA OBLONGATA; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATION CONTROL;

ANIMALS; ANIMALS, NEWBORN; DECEREBRATE STATE; EXCITATORY AMINO ACID AGONISTS; HYPEROXIA; KAINIC ACID; MEDULLA OBLONGATA; MICROINJECTIONS; PHRENIC NERVE; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY MECHANICS; RETICULAR FORMATION; VAGOTOMY;

EID: 0030946061     PISSN: 00345687     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5687(96)02513-3     Document Type: Article

References (25)

1. Arata, A., H. Onimaru and I. Homma (1990). Respiration-related neurons in the ventral medulla of newborn rats in vitro. Brain Res. Bull. 24: 599-604.
2. Connelly, C.A., E.G. Dobbins and J.L. Feldman (1992). Pre-Bötzinger complex in cats: respiratory neuronal discharge patterns. Brain Res. 590: 337-340.
3. Dobbins, E.G. and J.L. Feldman (1994). Brainstem network controlling descending drive to phrenic motoneurons in rat. J. Comp. Neurol. 347: 64-86.
4. Fung, M.-L., W. Wang and W.M. St. John (1994). Medullary loci critical for expression of gasping in adult rats. J. Physiol. (London) 480: 597-611.
5. Fung, M.-L. and W.M. St. John (1995). The functional expression of a pontine pneumotaxic centre in newborn rats. J. Physiol. (London) 489: 579-591.
6. Johnson, S.M., J.C. Smith, G.D. Funk and J.L. Feldman (1994). Pacemaker behavior of respiratory neurons in medullary slices from neonatal rats. J. Neurophysiol. 72: 2598-2608.
7. Lumsden, T. (1923). Observations on the respiratory centres in the cat. J. Physiol. (London) 57: 153-160.
8. Murakoshi, T., T. Suzue and S. Tamai (1985). A pharmacological study on respiratory rhythm in the isolated brainstem-spinal cord preparation of the newborn rat. Br. J. Pharmacol. 86: 95-104.
9. Nattie, E.E., A. Li and W.M. St. John (1991). Lesions in retrotrapezoid nucleus decrease ventilatory output in anesthetized or decerebrate cats. J. Appl. Physiol. 71: 1364-1375.
10. 2 sensitivity in rats. Respir. Physiol. 97: 63-77.
11. Onimaru, H., A. Arata and I. Homma (1989). Firing properties of respiratory rhythm generating neurons in the absence of synaptic transmission in rat medulla in vitro. Exp. Brain Res. 76: 530-536.
12. Onimaru, H., M. Kashiwagi, A. Arata and I. Homma (1993). Possible mutual excitatory couplings between inspiratory neurons in caudal ventrolateral medulla of brainstem-spinal cord preparation isolated from newborn rat. Neurosci. Lett. 150: 203-206.
13. Paxinos, G. and C. Watson (1986). The Rat Brain in Stereotaxic Coordinates. NSW, Australia: Academic Press.
14. Schwarzacher, S.W., J.C. Smith and D.W. Richter (1995). Pre-Bötzinger complex in the cat. J. Neurophysiol. 73: 1452-1461.
15. Smith, J.C., J.J. Greer, G.S. Liu and J.L. Feldman (1990). Neural mechanisms generating respiratory pattern in mammalian brain stem-spinal cord in vitro. I. Spatiotemporal patterns of motor and medullary neuron activity. J. Neurophysiol. 64: 1149-1169.
16. Smith, J.C., H.H. Ellenberger, K. Ballanyi, D.W. Richter and J.L. Feldman (1991). Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science 254: 726-729.
17. Speck, D.F. and J.L. Feldman (1982). The effects of microstimulation and microlesions in the ventral and dorsal respiratory groups in medulla of cat. J. Neurosci. 2: 744-757.
18. Speck, D.F. and E.R. Beck (1989). Respiratory rhythmicity after extensive lesions of the dorsal and ventral respiratory groups in the decerebrate cat. Brain Res. 482: 387-392.
19. St. John, W.M., T.A. Bledsoe and H.W. Sokol (1984). Identification of medullary loci critical for neurogenesis of gasping. J. Appl. Physiol. 56: 1008-1019.
20. St. John, W.M., T.A. Bledsoe and S.M. Tenney (1985). Characterization by stimulation of medullary mechanisms underlying gasping neurogenesis. J. Appl. Physiol. 58: 121-128.
21. St. John, W.M. (1990). Neurogenesis, control, and functional significance of gasping. J. Appl. Physiol. 68: 1305-1315.
22. St. John, W.M. (1996). Medullary regions for neurogenesis of gasping: noeud vital or noeuds vitals? J. Appl. Physiol. 81: 1865-1877.
23. Sun, M.-K. and D.J. Reis (1996). Excitatory amino acid-mediated chemoreflex excitation of respiratory neurones in rostral ventrolateral medulla in rats. J. Physiol. (London) 492: 559-571.
24. Suzue, T. (1984). Respiratory rhythm generation in the in vitro brain stem-spinal cord preparation of the neonatal rat. J. Physiol. (London) 354: 173-183.
25. Wang, W., M.-L. Fung, R.A. Darnall and W.M. St. John (1996). Characterizations and comparisons of eupnea and gasping in neonatal rats. J. Physiol. (London) 490: 277-292.