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Volumn 7, Issue 3, 1997, Pages 329-335

Galactose-induced dimerization of blocked ricin at acidic pH: Evidence for a third galactose-binding site in ricin B-chain

Author keywords

Blocked ricin; Galactose binding; Lectin; Ricin

Indexed keywords

GALACTOSE; LACTOSE; RICIN; RICIN B; UNCLASSIFIED DRUG;

EID: 0030946050     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: 10.1093/glycob/7.3.329     Document Type: Article
Times cited : (19)

References (32)
  • 1
    • 0018787411 scopus 로고
    • Structural determinants of Ricinus communis agglutinin and toxin specificity for oligosaccharides
    • Baenziger, J.U. and Fiete, D. (1979) Structural determinants of Ricinus communis agglutinin and toxin specificity for oligosaccharides. J. Biol. Chem., 254, 9795-9799.
    • (1979) J. Biol. Chem. , vol.254 , pp. 9795-9799
    • Baenziger, J.U.1    Fiete, D.2
  • 3
    • 0028023726 scopus 로고
    • Structure of influenza hemagglutinin at the pH of membrane fusion
    • Bullough, P.A., Hughson, F.M., Skehel, J.J. and Wiley, D.C. (1994) Structure of influenza hemagglutinin at the pH of membrane fusion. Nature, 371, 37-43.
    • (1994) Nature , vol.371 , pp. 37-43
    • Bullough, P.A.1    Hughson, F.M.2    Skehel, J.J.3    Wiley, D.C.4
  • 5
    • 0023219950 scopus 로고
    • RNA N-glycosidase activity of ricin A-chain: Mechanism of action of the toxic lectin on eukaryotic ribosomes
    • Endo, Y. and Tsurugi, K. (1987) RNA N-glycosidase activity of ricin A-chain: mechanism of action of the toxic lectin on eukaryotic ribosomes. J. Biol. Chem., 262, 8128-8130.
    • (1987) J. Biol. Chem. , vol.262 , pp. 8128-8130
    • Endo, Y.1    Tsurugi, K.2
  • 6
    • 0023050635 scopus 로고
    • Effect of physical environment on the conformation of ricin: Influence of low pH
    • Frénoy, J.P. (1986) Effect of physical environment on the conformation of ricin: influence of low pH. Biochem. J., 240, 221-226.
    • (1986) Biochem. J. , vol.240 , pp. 221-226
    • Frénoy, J.P.1
  • 7
    • 0026563849 scopus 로고
    • The specific cytotoxicity of immunoconjugates containing blocked ricin is dependent on the residual binding capacity of blocked ricin: Evidence that the membrane binding and A-chain translocation activities of ricin cannot be separated
    • Goldmacher, V.S., Lambert, J.M. and Blättler, W.A. (1992) The specific cytotoxicity of immunoconjugates containing blocked ricin is dependent on the residual binding capacity of blocked ricin: evidence that the membrane binding and A-chain translocation activities of ricin cannot be separated. Biochem. Biophys. Res. Commun., 183, 758-766.
    • (1992) Biochem. Biophys. Res. Commun. , vol.183 , pp. 758-766
    • Goldmacher, V.S.1    Lambert, J.M.2    Blättler, W.A.3
  • 9
    • 0026782106 scopus 로고
    • Correlation between in vivo toxicity and preclinical in vitro parameters for the immunotoxin anti-B4-blocked ricin
    • Grossbard, M.L., Lambert, J.M., Goldmacher, V.S., Blättler, W.A. and Nadler, L.M. (1992b) Correlation between in vivo toxicity and preclinical in vitro parameters for the immunotoxin anti-B4-blocked ricin. Cancer Res., 52, 4200-4207.
    • (1992) Cancer Res. , vol.52 , pp. 4200-4207
    • Grossbard, M.L.1    Lambert, J.M.2    Goldmacher, V.S.3    Blättler, W.A.4    Nadler, L.M.5
  • 10
    • 0020490555 scopus 로고
    • Binding of two molecules of 4-methylumbelliferyl galactose or 4-methylumbelliferyl N-acetylgalactosamine to the B chains of ricin and Ricinus communis agglutinin and to purified ricin B chain
    • Houston, L.L. and Dooley, L. (1982) Binding of two molecules of 4-methylumbelliferyl galactose or 4-methylumbelliferyl N-acetylgalactosamine to the B chains of ricin and Ricinus communis agglutinin and to purified ricin B chain. J. Biol. Chem., 257, 4147-4151.
    • (1982) J. Biol. Chem. , vol.257 , pp. 4147-4151
    • Houston, L.L.1    Dooley, L.2
  • 12
    • 0022425912 scopus 로고
    • Nucleotide sequence of cloned cDNA coding for preproricin
    • Lamb, F.I., Roberts, L.M. and Lord, J.M. (1985) Nucleotide sequence of cloned cDNA coding for preproricin. Eur. J. Biochem., 148, 265-270.
    • (1985) Eur. J. Biochem. , vol.148 , pp. 265-270
    • Lamb, F.I.1    Roberts, L.M.2    Lord, J.M.3
  • 13
    • 0025882239 scopus 로고
    • The galactose-binding sites of the cytotoxic lectin ricin can be chemically blocked in high yield with reactive ligands prepared by chemical modification of glycopeptides containing triantennary N-linked oligosaccharides
    • Lambert, J.M., McIntyre, G., Gauthier, M.N., Zullo, D., Rao, V., Steeves, R.M., Goldmacher, V.S. and Blättler, W.A. (1991a) The galactose-binding sites of the cytotoxic lectin ricin can be chemically blocked in high yield with reactive ligands prepared by chemical modification of glycopeptides containing triantennary N-linked oligosaccharides. Biochemistry, 30, 3234-3247.
    • (1991) Biochemistry , vol.30 , pp. 3234-3247
    • Lambert, J.M.1    McIntyre, G.2    Gauthier, M.N.3    Zullo, D.4    Rao, V.5    Steeves, R.M.6    Goldmacher, V.S.7    Blättler, W.A.8
  • 14
    • 0026354658 scopus 로고
    • An immunotoxin prepared with blocked ricin: A natural plant toxin adapted for therapeutic use
    • Lambert, J.M., Goldmacher, V.S., Collinson, A.R., Nadler, L.M. and Blattler, W.A. (1991b) An immunotoxin prepared with blocked ricin: a natural plant toxin adapted for therapeutic use. Cancer Res., 51, 6236-6242.
    • (1991) Cancer Res. , vol.51 , pp. 6236-6242
    • Lambert, J.M.1    Goldmacher, V.S.2    Collinson, A.R.3    Nadler, L.M.4    Blattler, W.A.5
  • 16
    • 0028098025 scopus 로고
    • Ricin: Structure, mode of action, and some current applications
    • Lord, J.M., Roberts, L.M. and Robertus, J.D. (1994) Ricin: structure, mode of action, and some current applications. FASEB J., 8, 201-208.
    • (1994) FASEB J. , vol.8 , pp. 201-208
    • Lord, J.M.1    Roberts, L.M.2    Robertus, J.D.3
  • 17
    • 0021089292 scopus 로고
    • Ricin B chain converts a non-cytotoxic antibody-ricin A chain conjugate into a potent and specific cytotoxic agent
    • McIntosh, D.P. Edwards, D.C., Cumber, A.J., Parnell, G.D., Dean, C.J., Ross-, W.C.J. and Forrester, J.A. (1983) Ricin B chain converts a non-cytotoxic antibody-ricin A chain conjugate into a potent and specific cytotoxic agent. FEBS Lett., 164, 17-20.
    • (1983) FEBS Lett. , vol.164 , pp. 17-20
    • McIntosh, D.P.1    Edwards, D.C.2    Cumber, A.J.3    Parnell, G.D.4    Dean, C.J.5    Ross-, W.C.J.6    Forrester, J.A.7
  • 19
    • 0017831463 scopus 로고
    • Ricin and Ricinus agglutinin, toxic lectins from castor bean
    • Olsnes, S. (1978) Ricin and Ricinus agglutinin, toxic lectins from castor bean. Methods Enzymol., 50, 330-335.
    • (1978) Methods Enzymol. , vol.50 , pp. 330-335
    • Olsnes, S.1
  • 20
    • 0015781481 scopus 로고
    • Different biological properties of the two constituent peptide chains of ricin, a toxic protein inhibiting protein synthesis
    • Olsnes, S. and Pihl, A. (1973) Different biological properties of the two constituent peptide chains of ricin, a toxic protein inhibiting protein synthesis. Biochemistry, 12, 3121-3126.
    • (1973) Biochemistry , vol.12 , pp. 3121-3126
    • Olsnes, S.1    Pihl, A.2
  • 21
    • 0002169483 scopus 로고
    • Toxic lectins and related proteins
    • Cohen, P. and Van Heyningen, S. (eds.), Elsevier Biomedical Press, Amsterdam
    • Olsnes, S. and Pihl, A. (1982) Toxic lectins and related proteins. In Cohen, P. and Van Heyningen, S. (eds.), Molecular Action of Toxins and Viruses. Elsevier Biomedical Press, Amsterdam, pp. 51-105.
    • (1982) Molecular Action of Toxins and Viruses , pp. 51-105
    • Olsnes, S.1    Pihl, A.2
  • 22
    • 0021205810 scopus 로고
    • Novel stereospecificity of the L-arabinose binding protein
    • Quiocho, F.A. and Vyas, N.K. (1984) Novel stereospecificity of the L-arabinose binding protein. Nature, 310, 381-386.
    • (1984) Nature , vol.310 , pp. 381-386
    • Quiocho, F.A.1    Vyas, N.K.2
  • 23
    • 0024375861 scopus 로고
    • Substrate specificity and affinity of a protein modulated by bound water molecules
    • Quiocho, F.A., Wilson, D.K. and Vyas, N.K. (1989) Substrate specificity and affinity of a protein modulated by bound water molecules. Nature, 340, 404-407.
    • (1989) Nature , vol.340 , pp. 404-407
    • Quiocho, F.A.1    Wilson, D.K.2    Vyas, N.K.3
  • 24
    • 0021714089 scopus 로고
    • Ricin B-chain and discoidin I share a common primitive protein fold
    • Robertus, J.D. and Ready, M.P. (1984) Ricin B-chain and discoidin I share a common primitive protein fold. J. Biol. Chem., 259, 13953-13956.
    • (1984) J. Biol. Chem. , vol.259 , pp. 13953-13956
    • Robertus, J.D.1    Ready, M.P.2
  • 25
    • 0025939115 scopus 로고
    • Structure of ricin B-chain at 2.5 Å resolution
    • Rutenber, E. and Robertus, J.D. (1991) Structure of ricin B-chain at 2.5 Å resolution. Proteins, 10, 260-269.
    • (1991) Proteins , vol.10 , pp. 260-269
    • Rutenber, E.1    Robertus, J.D.2
  • 26
    • 0023091105 scopus 로고
    • Structure and evolution of ricin B chain
    • Rutenber, E., Ready, M. and Robertus, J.D. (1987) Structure and evolution of ricin B chain. Nature, 326, 624-626.
    • (1987) Nature , vol.326 , pp. 624-626
    • Rutenber, E.1    Ready, M.2    Robertus, J.D.3
  • 28
    • 0026605274 scopus 로고
    • Phage display of ricin B-chain and its single binding domains: System for screening galactose-binding mutants
    • Swimmer, C., Lehar, S.M., McCafferty, J., Chiswell, D.J., Blättler, W.A. and Guild, B.C. (1992) Phage display of ricin B-chain and its single binding domains: system for screening galactose-binding mutants. Proc. Natl. Acad. Sci. USA, 89, 3756-3760.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 3756-3760
    • Swimmer, C.1    Lehar, S.M.2    McCafferty, J.3    Chiswell, D.J.4    Blättler, W.A.5    Guild, B.C.6
  • 29
  • 30
    • 0041130082 scopus 로고
    • Self-association of blocked ricin: Consequence of covalently blocking the galactose-binding sites of ricin by glycopeptide affinity ligands
    • Van Driessche, E., Fischer, J., Beeckmans, S. and Bog-Hansen, T.C. (eds), Textop, Hellerup, Denmark
    • Venkatesh, Y.P., Bottomley, S. and Lambert, J.M. (1994) Self-association of blocked ricin: consequence of covalently blocking the galactose-binding sites of ricin by glycopeptide affinity ligands. In Van Driessche, E., Fischer, J., Beeckmans, S. and Bog-Hansen, T.C. (eds), Lectins: Biology, Biochemists, Clinical Biochemistry, Vol. 10. Textop, Hellerup, Denmark, pp. 194-202.
    • (1994) Lectins: Biology, Biochemists, Clinical Biochemistry , vol.10 , pp. 194-202
    • Venkatesh, Y.P.1    Bottomley, S.2    Lambert, J.M.3
  • 31
    • 85036445156 scopus 로고
    • Synergy of ricin a chain-containing immunotoxins and ricin B chain-containing immunotoxins in in vitro killing of neoplastic human B cells
    • Vitetta, E.S., Cushley, W. and Uhr, J.W. (1983) Synergy of ricin A chain-containing immunotoxins and ricin B chain-containing immunotoxins in in vitro killing of neoplastic human B cells. Proc. Natl. Acad. Sci USA, 77, 5483-5486.
    • (1983) Proc. Natl. Acad. Sci USA , vol.77 , pp. 5483-5486
    • Vitetta, E.S.1    Cushley, W.2    Uhr, J.W.3
  • 32
    • 0018078474 scopus 로고
    • Binding of galactose and lactose to ricin: Equilibrium studies
    • Zentz, C., Frénoy, J.P. and Bourrillon, R. (1978) Binding of galactose and lactose to ricin: equilibrium studies. Biochim. Biophys. Acta, 536, 18-26.
    • (1978) Biochim. Biophys. Acta , vol.536 , pp. 18-26
    • Zentz, C.1    Frénoy, J.P.2    Bourrillon, R.3


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