Influence of simulated microgravity on the sympathetic response to exercise

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 272, Issue 2 41-2, 1997, Pages

  Woodman, Christopher R ^a,c   Kregel, Kevin C ^b   Tipton, Charles M ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

Author keywords

cardiovascular deconditioning; head down suspension; weightlessness; methyl para tyrosine

Indexed keywords

METIROSINE; NORADRENALIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART LEFT VENTRICLE; HEART OUTPUT; MALE; MICROGRAVITY; MUSCLE BLOOD FLOW; NONHUMAN; NORADRENALIN RELEASE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; SIMULATION; SOLEUS MUSCLE; SPLEEN; SYMPATHETIC TONE; TREADMILL EXERCISE; WEIGHTLESSNESS;

EID: 0030945175     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1997.272.2.r570     Document Type: Article

References (19)

1. Bedford, T. G., C. M. Tipton, N. C. Wilson, R. A. Opplinger, and C. V. Gisolfi. Maximum oxygen consumption of rats and its changes with various experimental protocols. J. Appl. Physiol. 47: 1278-1283, 1979.
2. Bhagat, B. The influence of sympathetic nervous system activity on cardiac catecholamine levels. J. Pharmacol. Exp. Ther. 157: 74-80, 1967.
3. Brodie, B. B., E. Costa, A. Dlabac, N. H. Neff, and H. H. Smookler. Application of steady state kinetics to the estimations of synthesis rate and turnover time in tissue catecholamines. J. Pharmacol. Exp. Ther. 154: 493-498, 1966.
4. Chang, P. C., E. Kreik, J. A. van der Krogt, and P. V. Brummelen. Does regional norepinephrine spillover represent local sympathetic activity? Hypertension Dallas 18: 56-66, 1991.
5. Delp, M. D., T. Holder-Binkley, M. H. Laughlin, and E. M. Hasser. Vasoconstrictor properties of rat aorta are diminished by hindlimb unweighting. J. Appl. Physiol. 75: 2620-2628, 1993.
6. Desplanches, D., R. Favier, B. Sempore, and H. Hoppeler. Whole body and muscle respiratory capacity with dobutamine and hindlimb suspension. J. Appl. Physiol. 71: 2419-2424, 1991.
7. Desplanches, D., M. H. Mayet, B. Sempore, and R. Flandrois. Structural and functional responses to prolonged hindlimb suspension in rat muscle. J. Appl. Physiol. 63: 558-563, 1987.
8. Fagette, S., J. Fareh, J. Cottet-Emard, J. Pequignot, G. Gauquelin, and C. Gharib. Effects of a short term hindlimb suspension on central and peripheral norepinephrine turnover in rats. Life Sci. 53: 555-561, 1993.
9. Fagette, S., L. Somody, F. Bouzeghrane, J. Cottet-Emard, C. Gharib, and G. Gauquelin. Central and peripheral sympathetic activities in rats during recovery from simulated weight-lessness. J. Appl. Physiol. 79: 1991-1997, 1995.
10. Fareh, J., J. Cottet-Emard, S. Fagette, J. Pequignot, and C. Gharib. Central and peripheral norepinephrine turnover after hindlimb suspension in the rat. Aviat. Space Environ. Med. 64: 386-391, 1993.
11. Girten, B., R. Tuttle, J. Cooper, and R. Glaser. Comparative maintenance effects of two synthetic catecholamines on exercise capacity after hindlimb suspension deconditioning in rats. ASGSB Bull. 4: 86, 1990.
12. Gordon, R., S. Spector, A. Sjoerdsma, and S. Udenfriend. Increased synthesis of norepinephrine and epinephrine in the intact rat during exercise and exposure to cold. J. Pharmacol. Exp. Ther. 153: 440-447, 1966.
13. Kregel, K. C., D. G. Johnson, and D. R. Seals. Tissue-specific noradrenergic activity during acute heat stress in rats. J. Appl. Physiol. 74: 1988-1993, 1993.
14. Mazzeo, R. S., and P. A. Grantham. Norepinephrine turnover in various tissues at rest and during exercise. Metabolism 38: 479-483, 1989.
15. McDonald, K. S., M. D. Delp, and R. H. Fitts. Effect of hindlimb unweighting on tissue blood flow in the rat. J. Appl. Physiol. 54: 2210-2218, 1992.
16. Morey, E. R.. Spaceflight and bone turnover: correlation with a new rat model of weightlessness. Biosciences 29: 168-172, 1979.
17. 2max and regional blood flow responses to exercise. J. Appl. Physiol. 66: 653-659, 1989.
18. Remensnyder, J. P., J. H. Mitchell, and S. J. Sarnoff. Functional sympatholysis during muscular activity. Circ. Res. 11: 370-380, 1962.
19. Woodman, C. R., L. A. Sebastian, and C. M. Tipton. Influence of simulated microgravity on cardiac output and blood flow distribution during exercise. J. Appl. Physiol. 79: 1762-1768, 1995.