Transforming growth factor B1 decreases uptake of glutathione precursor amino acids in bovine pulmonary artery endothelial cells

Endothelium: Journal of Endothelial Cell Research

Volumn 5, Issue 1, 1997, Pages 1-10

  Boustani, Maria R ^a   Hertig, Isabelle A ^a   Maloney, Erin K ^a   Fanburg, Barry L ^a   White, Alexander C ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cystine; Glutamate; Glutathione; Leucine; TGF 1

Indexed keywords

ACIVICIN; AMINO ACID; BUTHIONINE SULFOXIMINE; CYSTINE; GLUTAMIC ACID; GLUTATHIONE; LEUCINE; TRANSFORMING GROWTH FACTOR BETA1;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTERY ENDOTHELIUM; ARTICLE; CATTLE; CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; ENDOTHELIUM CELL; NONHUMAN; PRECURSOR; PULMONARY ARTERY;

EID: 0030945112     PISSN: 10623329     EISSN: None     Source Type: Journal    
DOI: 10.3109/10623329709044154     Document Type: Article

References (26)

1. Akerboom, T. P. M. and Sies, H. (1981) Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples. Methods Enzymol., 77, 373-382.
2. Bannai, S. and Tateishi, N. (1986) Role of membrane transport in metabolism and function of glutathione in mammals. J. Membr. Biol., 89, 1-8.
3. Border W. A. and Noble N. A. (1994) Transforming growth factor beta in tissue fibrosis. N. Engl. J. Med., 331, 1286-1292.
4. Broekelmann T. J., Limper A. H., et al. (1991) Transforming growth factor β1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc. Natl. Acad. Sci., 88, 6642-6646.
5. Bukowski D. M., Deneke S., et al. (1995) A noninducible cystine transport system in rat alveolar type II cells. Am. J. Physiol., 268, L21-L26.
6. Chang M., Shi M. and Forman H. J. (1992) Exogenous glutathione protects endothelial cells from menadione toxicity. Am. J. Physiol., L637-L643.
7. 111Indium as indicators of endothelial cell injury. Lab. Investi., 57, 578-584.
8. Christensen H. N. (1990) Role of amino acid transport and countertransport in nutrition and metabolism. Physiol. Rev., 70, 143-177.
9. 1 produces a "prooxidant" effect on bovine pulmonary artery endothelial cells in culture. Am. J. Physiol., 261, L249-L254.
10. Deneke S. (1992) Induction of cystine transport in bovine pulmonary artery endothelial cells by sodium arsenite. Biochim. Biophys. Acta., 1109, 127-131.
11. Deneke, S. M., Baxter, D. H., et al. (1989) Increase in endothelial cell glutathione and precursor amino acid uptake by diethyl maleate and hyperoxia. Am. J. Physiol., 257, L265-L271.
12. Deneke S. M., Lawrence R. A. and Jenkinson S. G. (1989) Endothelial cell cystine uptake and glutathione increase with N,N - bis (2-chloroethyl)-N-nitrosourea exposure. Am. J. Physiol., 262, L265-L271.
13. Deneke S. M., Steiger V. and Fanburg B. L. (1987) Effect of hyperoxia on glutathione levels and glutamic acid uptake in endothelial cells. J. Appl. Physiol., 63, 1966-1971.
14. Finkelstein J. N., Johnston C. J. et al. (1994) Early alterations in extracellular matrix and transforming growth factor β gene expression in mouse lung indicative of late radiation fibrosis. Int. J. Radiat. Oncol. Biol.-Phys., 28, 621-631.
15. Giri S. N., Hyde D. M. and Hollinger M. A. (1993) Effect of antibody to transforming growth factor β on bleomycin induced accumulation of lung collagen in mice. Thorax, 48, 959-966.
16. Harlan J. M., Levine, J. D., et al. (1984) Glutathione redox cycle protects cultured endothelial cells against lysis by extracellularly generated hydrogen peroxide. J. Clin. Invest., 73, 706-713.
17. Lee S. L. and Fanburg B. L. (1986) Serotonin uptake in bovine pulmonary artery endothelial cells in culture. I. Characterization. Am. J. Physiol., 250, C761-C765.
18. McCartney-Francis N. L. and Wahl S. M. (1994) Transforming growth factor β: A matter of life and death. J. Leukoc. Biol., 55, 401-109.
19. Miura K., Ishii T., et al. (1992) Cystine uptake and glutathione level in endothelial cells exposed to oxidative stress. Am. J. Physiol., 262, C50-C58.
20. 2. Am. J. Physiol., 268, L78-L84.
21. Schmidt K., Klatt P. and Mayer B. (1994) Characterization of endothelial cell amino acid transport systems involved in the actions of nitric oxide synthase inhibitors. Mol. Pharmacol., 44, 615-621.
22. Shi M. M., Iwamoto T. and Forman H. J. (1994) γ-glutamylcysteine synthetase and GSH increase in quinone-induced oxidative stress in BPAEC. Am. J. Physiol., 267, L414-L421.
23. Suttorp N., Toepper W. and Roka L. (1986) Antioxidant defense mechanisms of endothelial cells: glutathione redox cycle versus catalase. Am. J. Physiol., 251, C671-C680.
24. Steiger V., Deneke S. M. and Fanburg B. L. (1987) Characterization of glutamic acid uptake by bovine pulmonary arterial endothelial cells. J. Appl. Physiol., 63, 1961-1965.
25. Wahl S. (1994) Transforming growth factor β: the good, the bad, and the ugly. J. Exp. Med., 180, 1587-1590.
26. 1. Am. J. Respir. Cell Mol. Biol., 6, 364-368.