A synthetic method for diselenides under phase-transfer conditions

Synthetic Communications

Volumn 27, Issue 4, 1997, Pages 553-557

  Hu, Xubo ^a   Tian, Zhenjiao ^a   Lu, Xueran ^a   Chen, Yuanyin ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DISELENIDE; SELENIDE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; IN VITRO STUDY; METHODOLOGY; REACTION ANALYSIS;

EID: 0030944481     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1080/00397919708003325     Document Type: Article

References (22)

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22. A typical procedure for the preparation of diselenides: To the mixture of selenium (4. 0 g, 50mmnol) and sodium hydroxide (2. 0g, 100mmol) in water(30ml), 85% hydrazine hydrate (1. 0ml, 17mmol) was added under nitrogen. Heating it to 70 °C and stirring the mixture for 3h until all the selenium powder was consumed. Then 0. 3 g TBAB and alkyl halide (50mmol) were added. After the heavy oil seperated the reaction mixture was allowed to cool down to room temperature. The organic layer was seperated and the aquaous layer was extracted with petroleum ether (2 × 10ml). The combined organic layer was washed with water (2 × 20ml) followed with brine (2 × 20ml) and dried over anhydrous magnesium sulfate. After evaporation of the solvent the residue was recrystallized from cyclohexane (2a), or distilled (2b - 2e), or purified by column chromatography on silica gel(2f) to afford pure products.