Recombinant bet v 1, the major birch pollen allergen, induces hypersensitivity reactions equal to those induced by natural Bet v 1 in the airways of patients allergic to tree pollen

Journal of Allergy and Clinical Immunology

Volumn 99, Issue 3, 1997, Pages 354-358

  Godnic Cvar, Jasminka ^a,c   Susani, Markus ^b   Breiteneder, Heimo ^c   Berger, Alois ^a   Havelec, Liselotte ^c   Waldhör, Thomas ^a   Hirschwehr, Reinhold ^c   Valenta, Rudolf ^c   Scheiner, Otto ^c   Rüdiger, Hugo ^a   Kraft, Dietrich ^c   Ebner, Christof ^c  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Advanced Biological Systems   (Austria)

^c UNIVERSITY OF VIENNA   (Austria)

Author keywords

Bet v 1; bronchial asthma; provocation test; recombinant allergen; Type I allergy

Indexed keywords

HISTAMINE; IMMUNOGLOBULIN E; POLLEN ANTIGEN; RECOMBINANT DNA;

AIRWAY; ARTICLE; ASTHMA; CLINICAL ARTICLE; CONTROLLED STUDY; FORCED EXPIRATORY VOLUME; HUMAN; HYPERSENSITIVITY REACTION; IMMUNOBLOTTING; POLLEN ALLERGY; PRICK TEST; PRIORITY JOURNAL; PROVOCATION TEST; RADIOALLERGOSORBENT TEST; RECOMBINANT DNA TECHNOLOGY; RHINITIS; TREE;

EID: 0030944341     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(97)70053-8     Document Type: Article

References (11)

1. Scheiner O, Kraft D. Recombinant allergens: basic and practical aspects. Allergy 1995;50:384-95.
2. Breiteneder H, Pettenburger K, Bito A, Kraft D, Rumpold H, Scheiner O, et al. The gene coding for the major birch pollen allergen Bet v 1 is highly homologous to a pea disease resistance response gene. EMBO J 1989;8:1935-8.
3. Steward G A, Lake GR, Bird CH, Thompson PJ. Mite allergens as digestive enzymes. In: Sehon AH, Kraft D, Kunkel G, editors. Epitopes of atopic allergens. Brussels: UCB, 1989:83-6.
4. Ipsen H, Loewenstein H. Isolation and characterization of the major allergen of birch (Betula verrucosa). J Allergy Clin Immunol 1983;72:150-6.
5. Jarolim E, Rumpold H, Endler AT, Ebner H, Scheiner O, Kraft D. IgE and IgG antibodies of patients with allergy to birch pollen as tools to define the allergen profile of Betula verrucosa. Allergy 1989;44:385-95.
6. Ferreira F, Hoffmann-Sommergruber K, Breiteneder H, Pettenburger K, Ebner C, Szepfalusi Z, et al. Purification and characterization of recombinant Bet v 1, the major birch pollen allergen. Immunological equivalence to natural Bet v 1. J Biol Chem 1993;268:19574-80.
7. Reed CE, Zunginger JW. Quality assurance and standardization of allergy extracts in allergy practice. J Allergy Clin Immunol 1989;84:4-8.
8. Pauli GJ, Oster P, Deviller P, Heiss S, Bessot JC, Susani M, et al. Skin testing with recombinant allergens rBet v 1 and rBet v 2: diagnostic value for birch pollen and associated allergies. J Allergy Clin Immunol 1996;97:1100-9.
9. 4. Nature 1970;227:680-5.
10. Melillo G, Aas K, Cartier A, Davies RJ, Debelic M, Dreborg S, et al. Guidelines for the standardization of bronchial provocation tests with allergens. Allergy 1991;46:321-9.
11. Pepys J, Hutchcroft BJ. Bronchial provocation tests in etiologic diagnosis and analysis of asthma. Am Rev Respir Dis 1975;112:829-56.