Single dose artemisinin-mefloquine versus mefloquine alone for uncomplicated falciparum malaria

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 91, Issue 2, 1997, Pages 191-194

  Hung, Le Ngoc ^a   De Vries, Peter J ^b   Thuy, Lethi Diem ^a   Lien, Bich ^a   Long, Ho Phi ^c   Hung, Tran Nhu ^c   Nam, Nguyen Van ^d   Anh, Trinh Kim ^a   Kager, Piet A ^b  

^a CHO RAY HOSPITAL   (Viet Nam)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c Duc Linh District Hospital   (Viet Nam)

^d Provincial Malaria Station   (Viet Nam)

Author keywords

Artemisinin; Chemotherapy; Malaria; Mefloquine; Plasmodium falciparum; Viet Nam

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ; MEFLOQUINE;

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; GAMETOCYTE; HUMAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; VIET NAM;

PLASMODIUM FALCIPARUM;

EID: 0030944165     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-9203(97)90221-2     Document Type: Article

References (13)

1. Anh, T. K., Kim, N. V., Arnold, K., Chien, V. V., Bich, N. N., Thoa, K. & Ladinsky, J. (1990). Double-blind studies with mefloquine alone and in combination with sulfadoxine-pyrimethamine in 120 adults and 120 children with falciparum malaria in Viet Nam. Transactions of the Royal Society of Tropical Medicine and Hygiene, 84, 50-53.
2. Bunnag, D., Kanda, T., Karbwang, J., Thimasarn, K., Pungpak, S. & Harinasuta, T. (1995). Artemether-mefloquine combination in multidrug resistant falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 89, 213-215.
3. Duc, D. D., De Vries, P. J., Khahn, N. X., Binh, L. N., Kager, P. A. & Van Boxtel, C. J. (1994). The pharmacokinetics of a single dose of artemisinin in healthy Vietnamese subjects. American Journal of Tropical Medicine and Hygiene, 51, 785-790.
4. Dutta, G. P., Mohan, A. & Tripathi, R. (1990). Study of the gametocytocidal/sporontocidal action of qinghaosu (artemisinin) by electron microscopy. Journal of Parasitology, 76, 849-852.
5. Jiang, J.-B., Li, G.-Q., Guo, X.-B., Kong, Y. C. & Arnold, K. (1982). Antimalarial activity of mefloquine and qinghaosu. Lancet, ii, 285-288.
6. Karbwang, J., Na Bangchang, K., Tahanavibul, A., Back, D. J., Bunnag, D. & Harinasuta, T. (1994). Pharmacokinetics of mefloquine alone or in combination with artesunate. Bulletin of the World Health Organization, 72, 83-87.
7. Karbwang, J., Na-Bangchang, K., Thanavibul, A., Ditta-in, M. & Harinasuta, T. (1995). A comparative clinical trial of two different regimens of artemether plus mefloquine in multidrug resistant falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 89, 296-298.
8. Kumar, N. & Zheng, H. (1990). Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu on Plasmodium falciparum. Parasitology Research, 76, 214-218.
9. Li, G., Arnold, K., Guo, X., Jian, H. & Fu, L. (1984). Randomised comparative study of mefloquine, qinghaosu, and pyrimethamme-sulfadoxine in patients with falciparum malaria. Lancet, ii, 1360-1361.
10. Looareesuwan, S., Kyle, D. E., Viravan, C., Vanijanonta, S., Wilairatana, P., Charoenlarp, P., Canfield, C. J. & Webster, H. L. (1992). Treatment of patients with recrudescent falciparum malaria with a sequential combination of artesunate and mefloquine. American Journal of Tropical Medicine and Hygiene, 47, 794-799.
11. Nosten, F., Ter Kuile, F., Chongsuphajaisiddhi, T., Luxemburger, C., Webster, H. K., Edstein, M., Phaipun, L., Thew, K. L. & White, N. J. (1991). Mefloquine-resistant falciparum malaria on the Thai-Burmese border. Lancet, 337, 1140-1143.
12. WHO (1990). Practical Chemotherapy of Malaria. Geneva: World Health Organization, Technical Report Series, no. 805, pp. 30-31.
13. Wongsrichanalai, C., Webster, H. K., Womonwattrawatee, T., Sookto, P., Chuanak, N., Thimasarn, K. & Wernsdorfer, W. H. (1992). Emergence of multidrug-resistant Plasmodium falciparum in Thailand: in vitro tracking. American Journal of Tropical Medicine and Hygiene, 47, 112-116.