Valproic acid increases cerebrospinal fluid zidovudine levels in a patient with AIDS

American Journal of the Medical Sciences

Volumn 313, Issue 4, 1997, Pages 244-246

  Akula, Shiva K ^a,b   Rege, Arvind B ^b   Dreisbach, Albert W ^b   Dejace, Pierre M J T ^a,b   Lertora, Juan J L ^a,b  

^a DEPARTMENT OF VETERANS AFFAIRS   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AIDS; Cerebrospinal fluid; Valproic acid; Zidovudine

Indexed keywords

VALPROIC ACID; ZIDOVUDINE;

ADULT; ARTICLE; CASE REPORT; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG EFFECT; DRUG GLUCURONIDATION; DRUG HALF LIFE; DRUG POTENTIATION; DRUG UPTAKE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE;

EID: 0030944133     PISSN: 00029629     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000441-199704000-00009     Document Type: Article

References (18)

1. Sidtis JJ, Gastonis C, Price RW, Singer EJ, Collier AC, Richman DD, et al. Zidovudine treatment of the AIDS dementia complex - Results of a placebo-controlled trial. Ann Neurol. 1993;343-9.
2. Volberding, PA, Lagakos JW, Koch MA. Pettinelle C, Myers MW, Booth DK, et al. Zidovudine in asymptomatic human immunodeficiency virus infection: A controlled trial in person with fewer than 500 CD4-positive cells per cubic millimeter. N Engl J Med. 1990;322:941-9.
3. Kieburtz K, Zettelmair AE, Ketonenl, Tuite M, Caine ED. Manic syndrome in AIDS. Am J Psychiatry. 1991;148:1068-70.
4. Gerner RH, Stanton A. Algorithm for patient management of acute manic states: Lithium, valproate or carbamazepine? J Clin Psychopharmacol. 1992;12(suppl):57S-63S.
5. Lertora JJL, Rege AB, Greenspan DL, Akula SK, George WJ, Hyslop Jr NE, Agrawal KC. Pharmacokinetic interaction between zidovudine and valproic acid in patients Infected with human immunodeficiency virus. Clin Pharmacol Ther. 1994;56(3):272-8.
6. Price RW, Brew B, Sidtis JJ et al. The brain in AIDS: Central nervous system HIV-1 infection and the AIDS dementia complex. Science. 1988;239:586-92.
7. Schmitt FA, Bigley JW, McKinnis R, Logue PE, Evans RW, Drucker JL. Neuropsychological outcome of zidovudine (AZT) treatment of patients with AIDS and AIDS-Related complex. N Engl J Med. 1988;319:1573-8.
8. Navia BA, Jordan BD, Price RW. The AIDS dementia complex: I clinical features. Ann Neurol. 1986;19:517-24.
9. Perry SW. Organic mental disorders caused by HIV: Update on early diagnosis and treatment. Am J Psychiatry. 1990;147(6):696-710.
10. Portegies, deGans J, Lang JMA, Derix MM, Speelman H, Bakker M, et al. Declining incidence of AIDS dementia complex after introduction of zidovudine treatment. BMJ. 1989;299:819-21
11. Pizzo PF, Eddy J, Falloon J, Balis RM, Murphy RF, Moss H, et al. Effect of continuous intravenous infusion of zidovudine (AZT) in children with symptomatic HIV infection. N Engl J Med. 1988;319:889-96.
12. DeCarlic, Fugate L, Falloon J, Eddy J, Katz DA, Friedland RP, et al. Brain growth and cognitive improvement in children with human immunodeficiency virus-induced encephalopathy after six months of continuous infusion zidovudine therapy. J AIDS. 1991;4(6):585-92.
13. Hollweg M, Riedec RR, Goebh FB, Schick U, Naber D. Remarkable improvement of neuropsychiatric symptoms in HIV-infected patients after AZT therapy. Klinische Wochenshrift. 1991;69(9):409-12.
14. Pajeau AK, Roman GC. HIV encephalopathy and dementia review. Psychiatric Clinics of North America. 1992;15(2):455-66.
15. Vago L, Castagna A, Lazzarin A, Trabattoni G, Cinque P, Costanzi G. Reduced frequency of HIV-induced brain lesions in AIDS patients treated with zidovudine. J AIDS. 1993;6(1):42-5.
16. Tross S, Price RW, Navia B, Thaler HT, Gold J, Hirsch DA, Sidtis JJ. Neuropsychological characterization of the AIDS dementia complex: a preliminary report AIDS. 1988;2:81-8.
17. Komhauser DM, Hendrix CW, Nerhood LJ, Bartlett JG, Lietman PS. Probenecid and zidovudine metabolism. Lancet. 1989;2:473-5.
18. Agrawal KC, Dipiazza NJ, Aggarwal SK. Inhibition of human hepatic glucuronosyl transiferase (GT) activity to alter zidovudine (AZT) metabolism (abstract). Proc AM Assoc Cancer Res. 1992;33:400.