Comparative quantification of two hepatic UDP-glucuronosyltransferase bilirubin isoforms mRNAs in various thyroid states in rat

Biochemical Pharmacology

Volumn 53, Issue 7, 1997, Pages 1013-1017

  Masmoudi, Taoufik ^a   Mounié, Jacques ^a   Artur, Yves ^a   Magdalou, Jacques ^b   Goudonnet, Hervé ^a  

^a UFR Pharmacie   (France)

^b Centre du Medicament URA CNRS 597   (France)

Author keywords

3,5,3' triiodo L thyronine; bilirubin; gene expression; glucuronidation; rat liver; UDP glucuronosyltransferase

Indexed keywords

BILIRUBIN; CIPROFIBRATE; GLUCURONOSYLTRANSFERASE; LIOTHYRONINE;

ANIMAL TISSUE; ARTICLE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE LOCUS; GLUCURONIDATION; HYPERLIPIDEMIA; HYPOTHYROIDISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THYROIDECTOMY;

ANIMALS; CLOFIBRIC ACID; GENE EXPRESSION REGULATION; GLUCURONOSYLTRANSFERASE; ISOENZYMES; LIVER; MALE; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR; RNA, MESSENGER; THYROIDECTOMY; TRIIODOTHYRONINE;

EID: 0030943954     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(96)00886-6     Document Type: Article

References (18)

1. Crawford JM, Ransil BJ, Narciso JP and Gollan JL, Hepatic microsomal bilirubin UDP-glucuronosyltransferase. The kinetics of bilirubin mono- and diglucuronide synthesis. J Biol Chem 267: 16943-16950, 1992.
2. Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT and Owens IS, A novel complex locus UGT1 encodes human bilirubin phenol and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. J Biol Chem 167: 3257-3261, 1992.
3. Emi Y, Ikushiro S and lyanagi T, Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex. J Biochem 117: 392-399, 1995.
4. Chowdhury JR, Chowdhury NR, Moscioni AD, Tukey R and Tephly T, Differential regulation by triiodothyronine of substrate-specific uridine diphosphoglucuronate glucuronosyltransferases in rat liver. Biochim Biophys Acta 761: 58-65, 1983.
5. Goudonnet H, Magdalou J, Mounié J, Naoumi A, Viriot ML, Escousse A, Siest G and Truchot R, Differential action of thyroid hormones and chemically related compounds on the activity of UDP-glucuronosyltransferases and cytochrome P-450 isozymes in rat liver. Biochim Biophys Acta 1035: 12-19, 1990.
6. Foliot A, Drocourt JI, Etienne JP, Housset E, Fiessinger JN and Christoforov B, Increase in the hepatic glucuronidation and clearance of bilirubin in clofibrate-treated rats. Biochem Pharmacol 26: 547-549, 1977.
7. Pacot C, Charmoillaux M, Goudonnet H, Truchot RC and Latruffe N, Role of thyroid state on induction by ciprofibrate of laurate hydroxylase and peroxisomal enzymes in rat liver microsomes. Biochem Pharmacol 45: 1437-1446, 1993.
8. Masmoudi T, Planells R, Mounié J, Artur Y, Magdalou J and Goudonnet H, Opposite regulation of bilirubin and 4-nitrophenol UDP-glucuronosyltransferase mRNA levels by 3,3′,5 triiodo-L-thyronine in rat liver. FEBS Lett 379: 181-185, 1996.
9. Magdalou J, Fournel-Gigleux S, Goudonnet H, Pritchard M and Siest G, UDP-glucuronosyltransferases and peroxisome proliferators. In: Peroxisome Proliferators: Unique Inducers of Drug-Metabolizing Enzymes (Eds. David E Moody), pp. 79-95. CRC Press, Boca Raton, FL, 1994.
10. Coffman BL, Green MD, King CD and Tephly TR, Cloning and stable expression of a cDNA encoding a rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 1:1) that catalyzes the glucuronidation of opioids and bilirubin. Mol Pharmacol 47: 1101-1105, 1995.
11. Ozawa T, Tanaka M, Ikebe SI, Ohno K, Kondo T and Mizuno Y, Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis. Biochem Biophys Res Commun 172: 483-489, 1990.
12. Chelly J, Kaplan JC, Maire P, Gautron S and Kahn A, Transcription of the dystrophin gene in human muscle and non-muscle tissues. Nature 333: 858-860, 1988.
13. Mitsuhashi T and Nikodem V, Regulation of expression of the alternative mRNAs of the rat α-thyroid hormone receptor gene. J Biol Chem 264: 8900-8904, 1989.
14. Ma XJ, Salati LM, Ash SE, Mitchell DA, Kantley SA, Fantozzi DA and Goodridge AG, Nutritional regulation and tissue-specific expression of the malic enzyme gene in the chicken: Transcriptional control and chromatin structure. J Biol Chem 265: 18435-18441, 1990.
15. Ikushiro S, Emi Y and Iyanagi T, Identification and analysis of drug-responsive expression of UDP-glucuronosyltransferase family 1 (UGT1) isozyme in rat hepatic microsomes using anti-peptide antibodies. Arch Biochem Biophys 324: 267-272, 1995.
16. Aono S, Yamada Y, Keino H, Hanada N, Nakagawa T, Sasaoka Y, Yazawa T, Sato H and Koiwai O, Identification of a defect in the gene for bilirubin UDP-glucuronosyltransferase in a patient with Crigler-Najjar syndrome type-II. Biochem Biophys Res Commun 197: 1239-1244, 1993.
17. Bosma PJ, Seppen J, Goldhoorn B, Bakker C, Oude Elfink RPJ, Roy Chowdhury J, Roy Chowdhury N and Jansen PLM, Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man. J Biol Chem 269: 17960-17964, 1994.
18. Visser TJ, Kaptein E, Van Toor H, Van Raaij JAGM, Van Den Berg KJ, Tjong Tjin Joe C, Van Engelen JGM and Brouwer A, Glucuronidation of thyroid hormone in rat liver: Effects of in vivo treatment with microsomal enzyme inducers and in vitro assay conditions. Endocrinology 133: 2177-2186, 1993.