A methylenetetrahydrofolate reductase gene polymorphism in multiple sclerosis

European Journal of Neurology

Volumn 4, Issue 2, 1997, Pages 185-187

  Huang, W X ^a   He, B ^a   Hillert, J ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Folic acid; Genetic susceptibility; Methylenetetrahydrofolate reductase; Multiple sclerosis

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ALLELE; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MULTIPLE SCLEROSIS; PRIORITY JOURNAL;

EID: 0030943033     PISSN: 13515101     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1468-1331.1997.tb00325.x     Document Type: Article

References (20)

1. Crellin RF, Bottiglieri T and Reynolds EH (1990) Multiple sclerosis and macrocytosis. Acta Neurologica Scandanavica. 81, 388-391.
2. Ebers GC and Sadovnik AD (1994) The role of genetic factors in multiple sclerosis susceptibility. Journal of Neuroimmunology, 54, 1-17.
3. Ebers GC, Sadovnik AD, Risch NJ and the Canadian Collaborative Study Group (1995) A genetic basis for familial aggregation in multiple sclerosis. Nature, 377, 150-151.
4. Ellis FR, Nasser S and Wrighton RJ (1970) A survey of the use of vitamin B12 in general practice. Practitioner, 204, 838-842.
5. Frequin ST et al. (1993) Decreased vitamin B12 and folate levels in cerebrospinal fluid and serum of multiple sclerosis after high dose intravenous methylprednisolone. Journal of Neurology, 240, 305-308.
6. Frosst P et al. (1995) A candidate genetic risk factor for vascular disease: A common mutation in metheylentetrahydrofolate reductase. Nature, Genetics, 10, 111-113.
7. Goodkin DE et al. (1994) Serum cobalamin deficiency is uncommon in multiple sclerosis. Archives of Neurology, 51, 1110-1114.
8. Goyette P et al. (1994) Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation analysis. Nature, Genetics, 7, 195-200.
9. Gruener DM et al. (1994) Dietary vitamin B12 deficiency in a patient with multiple sclerosis. General Hospital Psychiatry, 16, 224-228.
10. Jersild C et al. (1973) Histocompatibility determinants in multiple sclerosis, with special reference to clinical course. Lancet, ii, 1221-1225.
11. Kira J, Tobimatsu S and Goto I (1994) Vitamin B12 metabolism and massive-dose methyl vitamin B12 therapy in Japanese patients with multiple sclerosis. Internal Medicine, 33, 82-86.
12. Najim Al-Din AS, Khojali M, Habbosh H, Farah S, Idris AR and Al-Muhtasib F (1991) Macrocytosis in multiple sclerosis. A study in 82 de nova Arab patients. Journal of Neurology, Neurosurgery and Psychiatry, 54, 415-416.
13. Nijst TQ et al. (1990) Vitamin B12 and folate concentrations in serum and cerebrospinal fluid of neurological patients with special reference to multiple sclerosis and dementia. Journal of Neurology, Neurosurgery and Psychiatry, 53, 951-954.
14. Olerup and Hillert (1991) HLA class II-associated genetic susceptibility in multiple sclerosis: a critical evaluation. Tissue Antigens, 38, 1-15.
15. Poser CM (1990) Macrocytosis and multiple sclerosis. Lancet, 6, 50.
16. Reynolds EH (1992) Multiple sclerosis and vitamin B12 metabolism. Journal of Neuroimmunology, 40, 225-230.
17. Reynolds EH, Bottiglieri T, Laundy M and Crellin RF (1992) Vitamin B12 metabolism and multiple sclerosis. Archives of Neurology, 49, 649-652.
18. Rio J et al. (1994) Serum homocystein levels in multiple sclerosis. Archives of Neurology, 51, 1181.
19. Sadovnik AD et al. (1993) A population based twin study of multiple sclerosis in twins: update. Annals of Neurology, 33, 281-285.
20. van den berg-Loonen EM, Hilteman TCM, Bins M, et al. (1982) Increased incidence of HLA.DR2 in patients with pernicious anaemia. Tissue Antigens, 19, 158-160.