Effects of prostacyclin substitution on systemic procoagulant turnover and cardiorespiratory variables in experimental hypercoagulability

Pathophysiology of Haemostasis and Thrombosis

Volumn 27, Issue 1, 1997, Pages 16-24

  Scherer, Ralf ^a   Schmidt, Ulrich ^b   Kox, Wolfgang ^c   Paar, Dietrich ^d  

^a Bundeswehrkrankenhaus Berlin   (Germany)

^b Pathologischen Institut   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Coagulation; Disseminated intravascular coagulation; Endotoxin; Hypercoagulability; Ischemia; Platelets; Prostacyclin; Rabbit

Indexed keywords

ANTITHROMBOCYTIC AGENT; ENDOTOXIN; FIBRIN; PROSTACYCLIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; DISSEMINATED INTRAVASCULAR CLOTTING; FEMALE; HYPERCOAGULABILITY; INTRAVENOUS DRUG ADMINISTRATION; MICROCIRCULATION; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMALS; ANTITHROMBIN III; BLOOD COAGULATION FACTORS; BLOOD COAGULATION TESTS; BLOOD PRESSURE; DISSEMINATED INTRAVASCULAR COAGULATION; EPOPROSTENOL; FIBRIN; INFUSIONS, INTRAVENOUS; KIDNEY; LIPOPOLYSACCHARIDES; LIVER; LUNG; MALE; RABBITS; RESPIRATORY FUNCTION TESTS;

EID: 0030942193     PISSN: 14248832     EISSN: 14248840     Source Type: Journal    
DOI: 10.1159/000217429     Document Type: Article

References (24)

1. Kroll MH. Harris TS. Moake JL, Handin RI, Schafer AI: Von Wille-brand factor binding to platelet GPIb initiates signals for platelet activation. J Clin Invest 1991;88: 1568-1573.
2. Schafer AI, Crawford DD, Gim-brone MA: Unidirectional transfer of prostaglandin peroxides between platelets and endothelial cells. J Clin Invest 1984;73:1105-1112.
3. l25I-anti-thrombin III binds to proteoheparin sulphate at the subendothclium of the rabbit aorta in vitro. Blood Vessels 1988:25:12-27.
4. Radomski MW. Palmer RM. Moneada S: The anti-aggregating properties of vascular endothelium: Interactions between prostacyclin and nitric oxide. Br J Pharmacol 1987; 92:639-646.
5. Edwards RL, Perla D: Effect of scrum on monocyte tissue factor generation. Blood 1984:64:707-714.
6. Altieri DC. Edgington TS: The saturable high affinity association of factor X to ADP-stimulatcd monocytes defines a novel function of the Mac-1 receptor. J Biol Chem 1988:263: 7007-7015.
7. Schafer AI. Crawford DD, Gim-brone MA: Unidirectional transfer of prostaglandin peroxides between platelets and endothelial cells. J Clin Invest 1984:73:1105-1112.
8. Rosenkranz B. Fischer C, Weimer KE. Frölich JC: Metabolism of prostacyclin and 6-keto-PFGia in man. J Biol Chem 1980;255:10194-10198.
9. Crutchlcy DJ. Conanan LB, Quc BG: Effects of prostacyclin analogs on the synthesis of tissue factor, tumor necrosis factor-alpha and interleukin-1 beta in human monocytic THP-1 cells. J Pharmacol ExpTher 1994;271:446-451.
10. Lechner K. Kyrie PA: Antithrombin III concentrates: Are they clinically useful? Thromb Haemost 1995;73: 340-348.
11. Scherer R, Giebler R. Schmidt U, Paar D, Wüst T, Spangenberg P, Militzer K. Hirchc H. Kox WJ: Short time rabbit model of endotoxin induced hypercoagulability. Lab AnimSci 1995;45:10-18.
12. Harten H: Die Thrombelastogra-phic: Eine Methode zur physikalischen Analyse des Blutgerinnungsvorganges. Z Exp Med 1951:117: 189-203.
13. Ingcrman-Wojenski CM, Silver MJ: A quick method for screening platelet dysfunctions using the whole blood lumi-aggregometcr. Thromb Haemost 1984;51:154-156.
14. Ricss H. Braun G. Brchm G: Critical evaluation of platelet aggregation in whole human blood. Am J Clin Pathol 1986;85:50-56.
15. Wiman B. Ran by M: Determination of soluble fibrin in plasma by a rapid and quantitative spectrophotomet-ric assay. Thromb Haemost 1986: 55:189-193.
16. Halvorsen S. Skjonsberg OH. Godal HC: Comparison of methods for detecting soluble fibrin in plasma from patients with venous thromboembolism. Thromb Res 1991;61:341-348.
17. Kirkwood BR: Essentials of Medical Statistics. Oxford. Blackwell Scientific Publications. 1988, pp 147-148.
18. Schcffé H: A method for judging all contrast in the analysis of variance. Biometrika 1953;40:87-104.
19. Thiemermann C, Lidbury PS, Thomas GR, Vane JR: Endothclin-1 releases prostacyclin and inhibits ex vivo platelet aggregation in the anesthetized rabbit. J Cardiovasc Pharmacol 1989;13:138-141.
20. Katsube N, Sakaguchi K, Fujitani B. Aishita H: Anti-platelet and antithrombotic effects of OP-41483.al-pha-CD. A prostacyclin analogue, in experimental animals. Prostaglandins Lcukot Esscnt Fatty Acids 1993:49:795-804.
21. Ito T. Asai F, Oshima T, Kobayashi S: Role of activated platelets in endotoxin-induced DIC in rats. Thromb Res 1990:59:735-747.
22. Matthias FR, Ditter H: The effects of prostacyclin on the endotoxin shock in rabbits. Folia Haematol 1990;117:209-218.
23. Vane JR, Anggard EE. Botting RM: Regulatory functions of the vascular endothelium. N Engl J Med 1990; 323:27-36.
24. Conary JT, Parker RE, Christman BW. Faulks RD, King GA, Meyrick BO, Brigham KL: Protection of rabbit lungs from endotoxin injury by in vivo hyperexpression of the prostaglandin G/H synthase gene. J Clin Invest 1994;93:1834-1840.