BNCT: Status and dosimetry requirements

Radiation Protection Dosimetry

Volumn 70, Issue 1-4, 1997, Pages 547-554

  Gahbauer, R ^a   Gupta, N ^a   Blue, T ^a   Goodman, J ^a   Grecula, J ^a   Soloway, A H ^a   Wambersie, A ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BORON DERIVATIVE;

CANCER THERAPY; CONFERENCE PAPER; DOSIMETRY; HUMAN; JAPAN; MAJOR CLINICAL STUDY; MICRODOSIMETRY; NEUTRON RADIATION; TUMOR CELL; UNITED STATES;

EID: 0030942018     PISSN: 01448420     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.rpd.a032014     Document Type: Conference Paper

References (65)

1. Walker, M. D., Alexander, E. and Hunt, W. Evaluation of BCNU and or Radiation Therapy in the Treatment of Anaplastic Gliomas (a Cooperative Clinical Trial). J Neurosurg, 49, 333-343 (1978).
2. Salazar, O. M., Rubin, P. and Feldstez, R. L. High Dose Radiation Therapy with Treatment of Localized Gliomas, Final Report. Int. J. Radiat. Oncol. Biol. Phys. 5, 1733-1740 (1979).
3. Laramore, G. E., Diener-West, M., Griffin, T. W., Nelson, J. S., Griem, M. L., Tomas, F. G., Hendrickson, F. R., Griffin, B. R., Myranthopoulas, L C. and Saxton, J. Randomized Neutron Dose Searching Study for Malignant Gliomas of the Brain: Results of an RTOG Study. Int. J. Radiat. Oncol. Biol. Phys. 14, 1093-1102 (1988).
4. Shih, J. A. and Brugger, R. M. Gadolinium as a Neutron Capture Therapy Agent. Med. Phys. 19(3), 733-744 (1992).
5. Matsumoto, T. Evaluation of Depth-dose Distributions for Gadolinium Neutron Capture Therapy. In: Advances in Neutron Capture Therapy. Eds A H. Soloway et al (New York: Plenum Press) pp. 235-240 (1993).
6. 7Li Reaction in Cells and Tissue and its Implication for Boron Neutron Capture Therapy. Radiat. Res. 111, 14-25 (1987).
7. Lemmen, P., Werner, B. and Streiches, B. Ether Lipids as Potential Boron Carriers for Boron Neutron Capture Therapy: Synthesis of rac-1-(9-0-carbororanyl)nonyl-2-methyl-glycero-3-phosphocholine (B-Et-11-Ome). In: Advances in Neutron Capture Therapy, Eds A. H. Soloway et al (New York: Plenum Press) pp. 297-300 (1993).
8. Wyzlic, I, M., Tjarks, W., Soloway, A. H., Anisuzzaman, A. K. M., Rong, Fj.-G and Barth, R. F. Strategies for the Design and Synthesis of Boronated Nucleic Acid and Protein Components as Potential Delivery Agents for Neutron Capture Therapy. Int. J. Radiat. Oncol. Biol. Phys. 28, 1203-1213 (1994).
9. Rong, F.-G., Soloway, A. H., Synthesis of 5-tethered Carborane-containing Pyrimidine Nucleotides as Potential Agents for DNA Incorporation. Nucleosides & Nucleotides, 13, 2021-2034 (1994).
10. Kahl, S. B. and Koo, M.-S. Synthesis and Properties of Tetrakis-carborane-carboxylate esters of 2,4-bis-(amb-dihydroxyethyl) deuteroporphyrin IX, In: Progress in Neutron Capture Therapy for Cancer, Eds B. J. Allen et al (New York: Plenum Press) pp. 223-226 (1992).
11. Tjarks, W., Malmquist, J., Gedda, L., Sjoberg, S. and Carlsson, J. Synthesis and Initial Biological Evaluation of Carborane-containing Phenanthrifinum Derivatives. In: Proc. Sixth Int. Symp on Neutron Capture Therapy for Cancer. Kobe, 31 Oct-4 Nov 1994, p. 112.
12. Scobie, M. and Threadgill, M. D. Synthesis of Carborane-containing Nitroimidazole Compounds via Mild 1.3-dipolar Cycloaddition. J. Chem. Soc. Chem. Commun. 13, 939-941 (1992).
13. Hariharan, J. R., Wyzlic, I. M. and Soloway, A. H. Synthesis of Novel Boron-containing Polyamines Agents for DNA Targeting in Neutron Capture Therapy. Polyhedron 14, 823-825 (1995).
14. Feakes, D. A., Shelly, K. J., Hawthorne, M. F., Schmidt, P. G., Elstad, C. A., Meadows, G. G. and Bauer, W. F. Liposomal Delivery of Boron to Murine Tumors for Boron Neutron Capture Therapy. In: Advances in Neutron Capture Therapy Eds A. H. Soloway et al (New York: Plenum Press) pp. 395-398 (1993).
15. Kahl, S. B., Pate, D. W. and Waunschel, L. A. Low Density Lipoprotein Reconstitutions with Alkyl and Aryl Carboranes. In: Advances in Neutron Capture Therapy. Eds A. H. Soloway et al (New York: Plenum Press) pp. 399-402 (1993).
16. Spielvogel, B. F., Soad, A., Powell, W., Tomasz, J., Porter, K. and Shaw, B. R. Chemical and Enzymatic Incorporation of Boron into DNA. In: Advances in Neutron Capture Therapy. Eds A. H. Soloway et al (New York: Plenum Press) pp. 389-393 (1993).
17. Liu, L., Barth, R. F., Adams, D. M., Soloway, A. H. and Reisfeld, R. A. Bispecific Antibodies as Targeting Agents for Boron Neutron Capture Therapy of Brain Tumors. J. Hematother. 4, 477-483 (1995).
18. Capala, J., Barth, R. F., Bendayan, M., Lauzon, M., Adams, D. M., Soloway A. H., Fenstermaker, R. A. and Carlsson, J. Boronated Epidermal Growth Factors as a Potential Targeting Agent for Boron Neutron Capture Therapy of Brain Tumors, Bioconjugate Chem. (in press).
19. Yang, W., Barth, R. F., Carpenter, D. E., Moeschberger, M. L. and Goodman, J. H. Enhanced Delivery of Boronophenylalanine by means of Intracarotid Injection and Blood Brain Barrier Disruption for Neutron Capture Therapy, J. Neuro-oncol. (submitted).
20. Barth, R. F., Soloway, A. H. and Fairchild, R. G. Boron Neutron Capture Therapy of Cancer. Cancer Res. 50, 1061-1070 (1990).
21. Sweet, W. Practical Problems of the Past in the Use of Boron-Slow Neutron Capture Therapy in the Treatment of Glioblastoma Multiforme. In: Proc. First Int. Symp. on Neutron Capture Therapy. Eds G. Brownell and R. G. Fairchild. BNL-51730, p. 376 (1983).
22. Kobayashi, T., Sakurai, Y. and Kanda, K. Study on Remodelling the Heavy Water Facility of the Kyoto University Reactor for Neutron Capture Therapy from the Concept of Neutron Energy Spectrum Control. In: Advances in Neutron Capture Therapy. Eds A. H. Soloway et al (New York: Plenum) pp. 29-32 (1993).
23. Moss, R. L. Progress Towards Boron Neutron Capture Therapy at the High Flux Reactor Petten. In: Neutron Beam Design, Development and Performance for Neutron Capture Therapy. Eds O. K. Harling et al. Basic Life Sciences 54 (New York: Pienum Press) pp. 169-183 (1985).
24. Liu, H. B. and Brugger, R. M. A Study of the concept of a Fission Plate as a Source for an Epithermal Neutron Beam. In: Proc. Sixth Int. Symp. on Neutron Capture Therapy, 31 Oct.-5 Nov. 1994 (in press).
25. Harling, O. K., Kiger, S. and Redmond II, E. L. High Intensity Fission Converter Based Epithermal Neutron Beam for Boron Neutron Capture Therapy. In: Proc. Sixth Int. Symp. on Neutron Capture Therapy, 10 Oct.-5 Nov. 1994 (in press).
26. Blue, J. W., Roberts, W. K., Blue, T. E., Gahbauer, R. A. and Vincent, J. S. A Study of Low Energy Proton Accelerators for Neutron Capture Therapy. In Neutron Capture Therapy Proc. Second International Symposium on Neutron Capture Therapy. Ed. H. Hatanaka. (Tokyo) pp. 147-158 (1985).
27. Wangler, T. P., Stovall, J. E., Bhatia, T. S., Wang, C. K., Blue, T. E. and Gahbauer, R. A. Conceptual Design of an RFQ Accelerator-based Neutron Source for Boron Neutron Capture Therapy. Los Alamos National Laboratory LA-UR-89-912. Particle Accelerator Conference, Chicago, IL, 20-23 March 1989.
28. Hamm, R. W. and Shubaly, M. R. A Pre-clinical Radio-frequency Quadrupole Linac for Boron Neutron Capture Therapy Measurements. In: Proc. First Int. Workshop on Accelerator-Based Neutron Sources for Boron Neutron Capture Therapy, Jackson, WY, 11-14 Sept. 1994. INEL Report Conference-940976, pp. 55-66 (1995).
29. Shefer, R. E., Klinkowstein R. E., Yanch, J. C. and Brownell, G. L. An Epithermal Neutron Source for BNCT using a Tandem Cascade Accelerator. In: Progress in Neutron Capture Therapy for Cancer. Eds B. N. Allen et al (New York: Plenum Press) pp. 119-122 (1992).
30. Shefer, R. E., Klinkowstein R. E., Yanch, J. C. and Howard, W. B. Tandem Electrostatic Accelerators for BNCT. In: Proc. First Int. Workshop on Accelerator-Based Neutron Sources for Boron Neutron Capture Therapy, Jackson, WY, 11-14 Sept. 1994. INEL Report Conference-940976, pp. 89-98 (1995).
31. Kwan, J W., Anderson. O. A, Reginato, L. L., Vella, M. C. and Yu, S. S. Electrostatic Quadrupole DC Accelerators for BNCT Applications. In: Proc. First Int. Workshop on Accelerator-Based Neutron Sources for Boron Neutron Capture Therapy, Jackson, WY, 11-14 Sept. 1994. INEL Report Conference-940976, pp. 111-120 (1995).
32. Swenson, D. A. A New Linac Structure for the BNCT Application. In: Proc. First Int. Workshop on Accelerator-Based Neutron Sources for Boron Neutron Capture Therapy. Jackson, WY, 11-14 Sept. 1994. INEL Report Conference-940976, pp. 121-128 (1995).
33. Gahbauer, R. G., Goodman, J. and Blue, T. Some Thoughts on Tolerance, Dose, and Fractionation in Boron Neutron Capture Therapy. In: Clinical Aspects of Neutron Capture Therapy -Proceedings of a Workshop on Boron Neutron Capture Therapy, Feb. 1988, Brookhaven National Laboratory. Eds Ralph G. Fairchild et al. Basic Life Sciences 50, 81-85 (New York: Plenum Press (1989).
34. Blue. T. E., Woollard, J. E., Gupta, N. and Gahbauer, R. A. Beam Design and Evaluation for BNCT. In: Proc. First Int. Workshop on Accelerator-Based Neutron Sources for Boron Neutron Capture Therapy, Jackson, WY, 11-14 Sept. 1994. INEL Report Conference-940976, pp. 197-210 (1995).
35. Grusell, E., Condé, H., Larsson, B., Ronnqvist, T., Sornsuntisook, O., Crawford, J., Reist, H., Dahl, B., Sjöstrand, N. G. and Russel, G. The Possible Use of a Spallation Neutron Source for Neutron Capture Therapy with Epithermal Neutrons. In: Neutron Beam Design, Development, and Performance for Neutron Capture Therapy, Eds O. K, Harling et al. Basic Life Sciences 54 (New York: Plenum Press) pp. 249-258 (1985).
36. Kim, J., Yanch, J. C, and Wilson, M. J. Californium-based Epithermal Neutron Beams for Neutron Capture Therapy. In: Advances in Neutron Capture Therapy, Proc. Fifth Int. Symp. on Neutron Capture Therapy, Columbus, OH, Sept. 1992. Eds A. H. Soloway et al (New York: Plenum Publishing) pp. 131-134 (1993).
37. Nigg, D. W., Mitchell, H. E., Harker, Y. D., Yoon, W. Y., Jones, J. L and Harmon, J. F. Epithermal Photoneutron Source Studies for BNCT. In: Proc. First Int. Workshop on Accelerator-Based Neutron Sources for Boron Neutron Capture Theapy, Jackson, WY, 11-14 Sept. 1994. INEL Report Conference-940976, pp. 373-386 (1995).
38. Jones, J. L. and Yoon, W. Y. Feasibility Study of the Application of a Linear Electron Accelerator to BNCT. In: Proc. 12th Int. Conf. on The Application of Accelerators in Research and Industry, University of North Texas, Denton, TX, November 1992.
39. Miley, G. H., Javedani, J. B., Gu, Y. B., Satsangi, A. J., Heck, P. F., Tzonev, I. D., Williams, M. J., Del Medico, S. G., Nebel, R. A., Barnes, D C., Turner, L., Nadler, J. H. and Sved, J. The IEC: a Novel Source for Boron Neutron Capture Therapy. In: Proc. First Int. Workshop on Accelerator-Based Neutron Sources for Boron Neutron Capture Therapy. Jackson. WY, 11-14 Sept. 1994. INEL Report Conference-940976, pp. 111-120 (1995).
40. Laramore, G. E., Wootton, P., Livesey, J. C., Wilbur, D. S., Risler, R., Phillips, M., Jacky, J., Buchholz, T. A., Griffin, T. W., Bossard, S., Boron Neutron Capture Therapy: a Mechanism for Achieving a Concomitant Tumor Boost in Fast Neutron Radiotherapy. Int J. Radiat. Oncol. Biol. Phys. 28(5), pp. 1135-1142 (1994).
41. Beach, J. L., Schroy, C. B., Ashtari, M., Harris, M. R. and Maruyama, Y. Boron Neutron Capture Enhancement of Cf-252 Brachytherapy. Int. J. Radiat. Oncol. Biol. Phys. 18, 1421-1427 (1990).
42. Gupta, N., Gahbauer, R. A., Blue T. E. and Wambersie, A. Dose Prescription in Boron Neutron Capture Therapy. Int. J. Radiat. Oncol. Biol. Phys. 28(5), pp. 1157-1166 (1994).
43. Deutsch, O. L. and Murray, B. W. Monte Carlo Dosimetry Calculation for Boron Neutron Capture Therapy in the Treatment of Brain Tumors. Nucl. Technol. 26, 320 (1976).
44. Rydin, R. A., Deutsch, O. L. and Murray, B. W. The Effect of Geometry on Capillary Wall Dose for Boron Neutron Capture Therapy. Phys. Med. Biol. 21, 134-138 (1976).
45. Gahbauer, R. A., Fairchild, R. G., Goodman, J. H. and Blue, T. E. Can Relative Biological Effectiveness be Used for Treatment Planning in Boron Neutron Capture Therapy? In: Tumor Response Monitoring and Treatment Planning. Ed. A. Breit (Berlin: Springer Verlag) (1992).
46. Blue, T. E., Gupta, N. and Wollard, J. E. A Calculation of the Energy Dependence of the RBE of Neutrons. Phys. Med. Biol. 38, 1693-1712 (1993).
47. Wheeler, F. J. Microdosimetric Calculations for Boron-drug Compound Factors for Boron Neutron Capture Therapy. Trans. Am. Nucl. Soc. 65, 147 (1992).
48. 10B Containing Region and a Concept of RBE for Neutron Capture Therapy. In: Advances in Neutron Capture Therapy. Eds A. H. Soloway et al (New York: Plenum) pp. 217-220 (1993).
49. 7Li Reaction Occuring at the Cellular Membrane. Int. J. Radiat. Oncol. Biol. Phys. 31(1), 171-178 (1995).
50. Wu, C. S., Amols, H. I., Kliauga, P., Reinstein, L. E. and Saraf, S. Microdosimetry for Boron Neutron Capture Therapy. Radiat. Res. 130(3), pp. 355-359 (1992).
51. Solares, G. R. and Zamenhof, R. G. A Novel Approach to the Microdosimetry of Neutron Capture Therapy, Part I: High-Resolution Quantitative Autoradiography Applied to Microdosimetry in Neutron Capture Therapy. Radiat. Res. (submitted).
52. Raaijmakers, C. P. J., Konijnenberg, M. W., Verhagen, H. W. and Mijnheer, B. J. Determination of Dose Components in Phantom Irradiated with an Epithermal Neutron Beam for Boron Neutron Capture Therapy. Med. Phys. 22(3), 321-329 (1995).
53. Harling, O. K., Moulin, D., Chabeuf, J.-M. and Solares, G. R. On-Line Beam Monitoring for Boron Neutron Capture Therapy at the MIT Research Reactor. In: Proc. Sixth Int. Symp. on Neutron Capture Therapy, 31 Oct-5 Nov 1994 (in press).
54. 10B Concentrations in Tissue for Neutron Capture Therapy by Prompt Gamma-ray Spectrometry. Nucl. Instrum. Methods 204, 525 (1983).
55. 10B Concentrations in Tissue. Nucl. Sci. Eng. 110, 96-103 (1992).
56. Barth, R. F., Adams, D. M., Soloway, A. H., Mechetner, E. B., Alam, F. and Anisuzzaman, A. K. M. Determination of Boron in Tissues and Cells using Direct-current Plasma Atomic Emission Spectroscopy. Anal. Chem. 63, 890-893 (1991).
57. Wheeler, F. J. and Nigg, D. W. Three Dimensional Radiation Dose Distribution Analysis for Boron Neutron Capture Therapy. Nucl. Sci. Eng. 110, 16-31 (1992).
58. Zamenhoff, R. G., Clement, S. D., Harling, O. K., Brenner, J. F., Wazer, D. E., Madoc-Jones, H. and Yanch, J. C. Monte Carlo Based Dosimetry and Treatment Planning for Neutron Capture Therapy of Brain Tumors. In: Proc. Int. Workshop on Neutron Beam Design, Development, and Performance for Neutron Capture Therapy. Eds O. K. Harling et al (Boston: Plenum) Basic Life Sci. 54, 283 (1989).
59. Reinstein, L. E., Ramsay, E. B., Gajewski, J., Rammamoorthy, S. and Meek, A. G. SBNCT-PLAN: A 3-dimensional Treatment Planning System for Boron Neutron Capture Therapy. In: Advances in OH, Sept 1992. Eds A. H. Soloway et al (New York: Plenum Publishing) pp. 171-175 (1993).
60. Nigg, D W., Randolph, P. D. and Wheeler, F. J. Demonstration of Three Dimensional Deterministic Radiation Transport Theory Dose Distribution Analysis for Boron Neutron Capture Therapy. Med. Phys. 18, 43-53 (1991).
61. Niemkiewicz, J., Blue, T. E. and Gupta, N. A Calculation of Neutron Flux Distributions in BNCT Using Removal-Diffusion Theory. Trans. Am. Nucl. Soc. 70, 13-15 (1994).
62. 2H Dose Calculations in BNCT. Trans. Am. Nucl. Soc. 65, 155-157 (1992).
63. Fairchild, R. G., Saraf, S. K., Kalef-Ezra, J. and Laster, B. H. Comparison of Measured Parameters from a 24-Key and a Broad Spectrum Epithermal Neutron Beam for Neutron Capture Therapy: an Identification of Consequential Parameters Med. Phys. 17, 1045-1052 (1990).
64. Joel, D. personal communications.
65. Madoc-Jones, H., Zamenhof, R., Solares, G., Harling, O., Yam, C.-S., Riley, K., Wazer, D., Rogers, G. and Atkins, M. A Phase-I Dose-Escalation Trial of Boron Neutron Capture Therapy For Subjects with Metastatic Subcutaneous Melanoma of the Extremities (submitted).