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Volumn 10, Issue 6, 1997, Pages 703-709

Inotropic agents in the treatment of heart failure: Despair or hope?

Author keywords

Beta receptor; Cyclic AMP; Cytokines; Immunomodulation; Intracellular Ca2+; Phosphodiesterase inhibitor; Survival

Indexed keywords

CALCIUM SENSITIZER; CARDIOTONIC AGENT; CYCLIC AMP; DIGITALIS; IMMUNOMODULATING AGENT; INOTROPIC AGENT; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PIMOBENDAN; PIPERANOMETOZINE;

EID: 0030941970     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00053027     Document Type: Review
Times cited : (16)

References (70)
  • 1
    • 0027423351 scopus 로고
    • The epidemiology of heart failure: The Framingham Study
    • Ho KKL, Pinsky JL, Kannel WB, Levy D. The epidemiology of heart failure: The Framingham Study. J Am Coll Cardiol 1993;22(Suppl A):6A-13A.
    • (1993) J Am Coll Cardiol , vol.22 , Issue.SUPPL. A
    • Ho, K.K.L.1    Pinsky, J.L.2    Kannel, W.B.3    Levy, D.4
  • 2
    • 0014643560 scopus 로고
    • Rate of calcium binding and up-take in normal animal and failing human cardiac muscle
    • Harigaya S, Schwartz A. Rate of calcium binding and up-take in normal animal and failing human cardiac muscle. Circ Res 1969;25:781-794.
    • (1969) Circ Res , vol.25 , pp. 781-794
    • Harigaya, S.1    Schwartz, A.2
  • 3
    • 0023130366 scopus 로고
    • Deficient production of cyclic AMP: Pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure
    • Feldman MD, Copelas L, Gwathmey JK, et al. Deficient production of cyclic AMP: Pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure. Circulation 1987;75:331-339.
    • (1987) Circulation , vol.75 , pp. 331-339
    • Feldman, M.D.1    Copelas, L.2    Gwathmey, J.K.3
  • 4
    • 0027360573 scopus 로고
    • The development of positive inotropic agents for chronic heart failure: How have we gone astray?
    • Packer M. The development of positive inotropic agents for chronic heart failure: How have we gone astray? J Am Coll Cardiol 1993;22(Suppl A):119A-126A.
    • (1993) J Am Coll Cardiol , vol.22 , Issue.SUPPL. A
    • Packer, M.1
  • 5
    • 0026532390 scopus 로고
    • What do the newer inotropic drugs have to offer?
    • Sasayama S. What do the newer inotropic drugs have to offer? Cardiovasc Drugs Ther 1992;6:15-18.
    • (1992) Cardiovasc Drugs Ther , vol.6 , pp. 15-18
    • Sasayama, S.1
  • 6
    • 0027442361 scopus 로고
    • Medical advances in the treatment of congestive heart failure
    • Armstrong PW, Moe GW. Medical advances in the treatment of congestive heart failure. Circulation 1994;88: 2941-2952.
    • (1994) Circulation , vol.88 , pp. 2941-2952
    • Armstrong, P.W.1    Moe, G.W.2
  • 7
    • 0019982539 scopus 로고
    • Decreased catecholamine sensitivity and beta-adrenergic receptor density in failing human hearts
    • Bristow MR, Ginsburg R, Minobe W, et al. Decreased catecholamine sensitivity and beta-adrenergic receptor density in failing human hearts. N Engl J Med 1982;307:205-211.
    • (1982) N Engl J Med , vol.307 , pp. 205-211
    • Bristow, M.R.1    Ginsburg, R.2    Minobe, W.3
  • 8
    • 0021320662 scopus 로고
    • Long-term hemodynamic effects of prenalterol in patients with severe congestive heart failure
    • Lambertz H, Meyer J, Erbel R. Long-term hemodynamic effects of prenalterol in patients with severe congestive heart failure. Circulation 1984;69:298-305.
    • (1984) Circulation , vol.69 , pp. 298-305
    • Lambertz, H.1    Meyer, J.2    Erbel, R.3
  • 10
    • 0022981068 scopus 로고
    • Cardiovascular effects of ICI 118,587, a new beta-adrenoceptor partial agonist in man
    • Sasayama S, Yokawa S, Akiyama M, Mikawa M, Sakai O. Cardiovascular effects of ICI 118,587, a new beta-adrenoceptor partial agonist in man. Jpn Circ J 1986;50: 636-643.
    • (1986) Jpn Circ J , vol.50 , pp. 636-643
    • Sasayama, S.1    Yokawa, S.2    Akiyama, M.3    Mikawa, M.4    Sakai, O.5
  • 11
    • 0023879889 scopus 로고
    • Long-term effects of xamoterol on left ventricular diastolic function and late remodeling: A study in patients with anterior myocardial infarction and single-vessel disease
    • Pouleur H, van Eyll C, Hanet C, Cheron P, Charlier AA, Rousseau MF. Long-term effects of xamoterol on left ventricular diastolic function and late remodeling: A study in patients with anterior myocardial infarction and single-vessel disease. Circulation 1988;77:1081-1089.
    • (1988) Circulation , vol.77 , pp. 1081-1089
    • Pouleur, H.1    Van Eyll, C.2    Hanet, C.3    Cheron, P.4    Charlier, A.A.5    Rousseau, M.F.6
  • 12
    • 0025279763 scopus 로고
    • Xamoterol in severe heart failure
    • The Xamoterol in Severe Heart Failure Study Group. Xamoterol in severe heart failure. Lancet 1990;336:1-6.
    • (1990) Lancet , vol.336 , pp. 1-6
  • 14
    • 0021736464 scopus 로고
    • Hemodynamic and clinical limitation of long-term inotropic therapy with amrinone in patients with severe chronic heart failure
    • Packer M, Medina N, Yushak H. Hemodynamic and clinical limitation of long-term inotropic therapy with amrinone in patients with severe chronic heart failure. Circulation 1984; 70:1038-1047.
    • (1984) Circulation , vol.70 , pp. 1038-1047
    • Packer, M.1    Medina, N.2    Yushak, H.3
  • 15
    • 0022649606 scopus 로고
    • Persistent hemodynamic effects without long-term clinical benefits in response to oral piroximone (MDL 19,205) in patients with congestive heart failure
    • Petein M, Levine B, Cohn JN. Persistent hemodynamic effects without long-term clinical benefits in response to oral piroximone (MDL 19,205) in patients with congestive heart failure. Circulation 1986;73(Suppl III):III230-III236.
    • (1986) Circulation , vol.73 , Issue.3 SUPPL.
    • Petein, M.1    Levine, B.2    Cohn, J.N.3
  • 16
    • 0025071304 scopus 로고
    • Multicenter trial of oral enoximone in patients with moderate to moderately severe congestive heart failure. Lack of benefit compared with placebo
    • Uretsky BF, for the Enoximone Multicenter Trial Group. Multicenter trial of oral enoximone in patients with moderate to moderately severe congestive heart failure. Lack of benefit compared with placebo. Circulation 1990;82:774-780.
    • (1990) Circulation , vol.82 , pp. 774-780
    • Uretsky, B.F.1
  • 17
    • 0021865534 scopus 로고
    • Long-term oral administration of amrinone for congestive heart failure: Lack of efficacy in a multicenter controlled trial
    • Massie B, Bourassa M, DiBianco R, Hess M, Konstam M, Likoff M, Packer M, for the Amrinone Multicenter Trial Group. Long-term oral administration of amrinone for congestive heart failure: Lack of efficacy in a multicenter controlled trial. Circulation 1985;71:963-971.
    • (1985) Circulation , vol.71 , pp. 963-971
    • Massie, B.1    Bourassa, M.2    DiBianco, R.3    Hess, M.4    Konstam, M.5    Likoff, M.6    Packer, M.7
  • 18
    • 0021723922 scopus 로고
    • Oral amrinone for the treatment of chronic congestive heart failure: Results of a multicenter randomized double-blind and placebo-controlled withdrawal study
    • DiBianco R, for the Amrinone Multicenter Study Investigators. Oral amrinone for the treatment of chronic congestive heart failure: Results of a multicenter randomized double-blind and placebo-controlled withdrawal study. J Am Coll Cardiol 1984;4:855-866.
    • (1984) J Am Coll Cardiol , vol.4 , pp. 855-866
    • DiBianco, R.1
  • 19
    • 0026072848 scopus 로고
    • Effect of oral milrinone on mortality in severe chronic heart failure
    • Packer M, for the PROMISE Study Research Group. Effect of oral milrinone on mortality in severe chronic heart failure. N Engl J Med 1991;325:1468-1475.
    • (1991) N Engl J Med , vol.325 , pp. 1468-1475
    • Packer, M.1
  • 20
    • 0027365840 scopus 로고
    • Efficacy of phosphodiesterase inhibition with milrinone in combination with converting enzyme inhibitors in patients with heart failure
    • Colucci WS, for the Milrinone Multicenter Trials Investigators. Efficacy of phosphodiesterase inhibition with milrinone in combination with converting enzyme inhibitors in patients with heart failure. J Am Coll Cardiol 1993; 22(Suppl A):113A-118A.
    • (1993) J Am Coll Cardiol , vol.22 , Issue.SUPPL. A
    • Colucci, W.S.1
  • 21
    • 0018836852 scopus 로고
    • Stereological measurement of cellular and subcellular hypertrophy and hyperplasia in the papillary muscle of adult rat
    • Anversa P, Olivetti G, Melissari M, Loud AV. Stereological measurement of cellular and subcellular hypertrophy and hyperplasia in the papillary muscle of adult rat. J Mol Cell Cardiol 1980;12:781-795.
    • (1980) J Mol Cell Cardiol , vol.12 , pp. 781-795
    • Anversa, P.1    Olivetti, G.2    Melissari, M.3    Loud, A.V.4
  • 23
    • 0027230922 scopus 로고
    • Is cardiac failure a consequence of decreased energy reserve?
    • Ingwall JS. Is cardiac failure a consequence of decreased energy reserve? Circulation 1993;87(Suppl VII):VII58-VII62.
    • (1993) Circulation , vol.87 , Issue.7 SUPPL.
    • Ingwall, J.S.1
  • 24
    • 0028928856 scopus 로고
    • Antibody-mediated imbalance of myocardial energy metabolism. A causal factor of cardiac failure?
    • Schultheiss HP, Schulze K, Schauer R, et al. Antibody-mediated imbalance of myocardial energy metabolism. A causal factor of cardiac failure? Circ Res 1995;76:64-72.
    • (1995) Circ Res , vol.76 , pp. 64-72
    • Schultheiss, H.P.1    Schulze, K.2    Schauer, R.3
  • 25
    • 0013606550 scopus 로고
    • Potential deleterious effects of inotropic agents in the therapy of chronic heart failure
    • Katz AM. Potential deleterious effects of inotropic agents in the therapy of chronic heart failure. Circulation 1986; 73(Suppl III):III184-III190.
    • (1986) Circulation , vol.73 , Issue.3 SUPPL.
    • Katz, A.M.1
  • 26
    • 0028941105 scopus 로고
    • Scientific insights from clinical studies of converting-enzyme inhibitors in the failing heart
    • Katz AM. Scientific insights from clinical studies of converting-enzyme inhibitors in the failing heart. Trends Cardiovasc Med 1995;5:37-44.
    • (1995) Trends Cardiovasc Med , vol.5 , pp. 37-44
    • Katz, A.M.1
  • 27
    • 0026747161 scopus 로고
    • Potential arrhythmogenic role of cyclic adenosine monophosphate (AMP) and cytosolic calcium overload: Implications for prophylactic effects of beta-blockers in myocardial infarction and proarrhythmic effects of phosphodiesterase inhibitors
    • Lubbe WF, Podzuweit T, Opie LH. Potential arrhythmogenic role of cyclic adenosine monophosphate (AMP) and cytosolic calcium overload: Implications for prophylactic effects of beta-blockers in myocardial infarction and proarrhythmic effects of phosphodiesterase inhibitors. J Am Coll Cardiol 1992;19:1622-1633.
    • (1992) J Am Coll Cardiol , vol.19 , pp. 1622-1633
    • Lubbe, W.F.1    Podzuweit, T.2    Opie, L.H.3
  • 28
    • 0019959636 scopus 로고
    • Transient depolarizations and spontaneous voltage fluctuations in isolated single cells from guinea pig ventricles
    • Matsuda H, Noma A, Kurachi Y, Irisawa H. Transient depolarizations and spontaneous voltage fluctuations in isolated single cells from guinea pig ventricles. Circ Res 1982; 51:142-151.
    • (1982) Circ Res , vol.51 , pp. 142-151
    • Matsuda, H.1    Noma, A.2    Kurachi, Y.3    Irisawa, H.4
  • 29
    • 0020569706 scopus 로고
    • Effects of discontinuing maintenance digoxin therapy in patients with ischemic heart disease and congestive heart failure in sinus rhythm
    • Gheorghiade M, Beller GA. Effects of discontinuing maintenance digoxin therapy in patients with ischemic heart disease and congestive heart failure in sinus rhythm. Am J Cardiol 1983;51:1243-1250.
    • (1983) Am J Cardiol , vol.51 , pp. 1243-1250
    • Gheorghiade, M.1    Beller, G.A.2
  • 30
    • 0020335461 scopus 로고
    • Is digoxin really important in treatment of compensated heart failure? A placebo-controlled crossover study in patients with sinus rhythm
    • Fleg JL, Gottlieb SH, Lakatta EG. Is digoxin really important in treatment of compensated heart failure? A placebo-controlled crossover study in patients with sinus rhythm. Am J Med 1982;73:244-250.
    • (1982) Am J Med , vol.73 , pp. 244-250
    • Fleg, J.L.1    Gottlieb, S.H.2    Lakatta, E.G.3
  • 31
    • 0024337347 scopus 로고
    • Digoxin - A redundant drug in congestive cardiac failure
    • Poole-Wilson PA, Robinson K. Digoxin - A redundant drug in congestive cardiac failure. Cardiovasc Drugs Ther 1989; 2:733-741.
    • (1989) Cardiovasc Drugs Ther , vol.2 , pp. 733-741
    • Poole-Wilson, P.A.1    Robinson, K.2
  • 32
    • 0024402581 scopus 로고
    • Sympathoinhibitory responses to digitalis glycosides in heart failure patients: Direct evidence from sympathetic neural recordings
    • Ferguson DW, Berg WJ, Sanders JS, Roach PJ, Kempf JS, Kienzle ME. Sympathoinhibitory responses to digitalis glycosides in heart failure patients: Direct evidence from sympathetic neural recordings. Circulation 1989;80:65-77.
    • (1989) Circulation , vol.80 , pp. 65-77
    • Ferguson, D.W.1    Berg, W.J.2    Sanders, J.S.3    Roach, P.J.4    Kempf, J.S.5    Kienzle, M.E.6
  • 33
    • 0020564363 scopus 로고
    • Suppression of the renin-angiotensin system by intravenous digoxin in chronic congestive heart failure
    • Covit AB, Schaer GL, Sealey JE, Laragh JH, Cody RJ. Suppression of the renin-angiotensin system by intravenous digoxin in chronic congestive heart failure. Am. J Med 1983; 75:445-447.
    • (1983) Am. J Med , vol.75 , pp. 445-447
    • Covit, A.B.1    Schaer, G.L.2    Sealey, J.E.3    Laragh, J.H.4    Cody, R.J.5
  • 34
    • 0024294162 scopus 로고
    • Comparative effects of therapy with captopril and digoxin in patients with mild to moderate heart failure
    • Captopril-Digoxin Multicenter Research Group. Comparative effects of therapy with captopril and digoxin in patients with mild to moderate heart failure. JAMA 1988;259: 539-544.
    • (1988) JAMA , vol.259 , pp. 539-544
  • 35
    • 84920214594 scopus 로고
    • Double blind placebo-controlled comparison of digoxin and xamoterol in chronic heart failure
    • The German and Austrian Xamoterol Study Group. Double blind placebo-controlled comparison of digoxin and xamoterol in chronic heart failure. Lancet 1988;1:489-493.
    • (1988) Lancet , vol.1 , pp. 489-493
  • 36
    • 0024511994 scopus 로고
    • A comparison of oral milrinone, digoxin, and their combination in the treatment of patients with chronic heart failure
    • DiBianco R, for the Milrinone Multicenter Trial Group. A comparison of oral milrinone, digoxin, and their combination in the treatment of patients with chronic heart failure. N Engl J Med 1989;320:677-683.
    • (1989) N Engl J Med , vol.320 , pp. 677-683
    • DiBianco, R.1
  • 37
    • 0027216221 scopus 로고
    • Withdrawal of digoxin from patients with chronic heart failure treated with angiotensin-converting-enzyme inhibitors
    • Packer M, for the RADIANCE Study. Withdrawal of digoxin from patients with chronic heart failure treated with angiotensin-converting-enzyme inhibitors. N Engl J Med 1993;329:1-7.
    • (1993) N Engl J Med , vol.329 , pp. 1-7
    • Packer, M.1
  • 38
    • 0028877686 scopus 로고
    • Effect of long-term digoxin therapy on autonomic function in patients with chronic heart failure
    • Krum H, Bigger JT, Goldsmith RL, Packer M. Effect of long-term digoxin therapy on autonomic function in patients with chronic heart failure. J Am Coll Cardiol 1995;25: 289-294.
    • (1995) J Am Coll Cardiol , vol.25 , pp. 289-294
    • Krum, H.1    Bigger, J.T.2    Goldsmith, R.L.3    Packer, M.4
  • 39
    • 0026629110 scopus 로고
    • Need for a large randomized trial to evaluate the effects of digitalis on morbidity and mortality in congestive heart failure
    • Yusuf S, Garg R, Held P, Gorlin R. Need for a large randomized trial to evaluate the effects of digitalis on morbidity and mortality in congestive heart failure. Am J Cardiol 1992;69:64G-70G.
    • (1992) Am J Cardiol , vol.69
    • Yusuf, S.1    Garg, R.2    Held, P.3    Gorlin, R.4
  • 40
    • 1842298444 scopus 로고    scopus 로고
    • The effect of digitalis on mortality and hospitalations in patients with heart failure
    • Orlando, Florida
    • Gorlin R. The effect of digitalis on mortality and hospitalations in patients with heart failure. Presentation of the 45th Annual Scientific Session of the American College of Cardiology, Orlando, Florida, 1996.
    • (1996) 45th Annual Scientific Session of the American College of Cardiology
    • Gorlin, R.1
  • 41
    • 0022601316 scopus 로고
    • Acute hemodynamic effects of a new inotropic agent, OPC-8212, on severe congestive heart failure
    • Sasayama S, Inoue M, Asanoi H, Kodama K, Hori M, Sakurai T, Kawai C. Acute hemodynamic effects of a new inotropic agent, OPC-8212, on severe congestive heart failure. Heart Vessels 1986;2:23-28.
    • (1986) Heart Vessels , vol.2 , pp. 23-28
    • Sasayama, S.1    Inoue, M.2    Asanoi, H.3    Kodama, K.4    Hori, M.5    Sakurai, T.6    Kawai, C.7
  • 42
    • 0023101566 scopus 로고
    • Membrane current changes responsible for the positive inotropic effect of OPC-8212, a new positive inotropic agent, in single ventricular cells of the guinea pig heart
    • Iijima T, Taira N. Membrane current changes responsible for the positive inotropic effect of OPC-8212, a new positive inotropic agent, in single ventricular cells of the guinea pig heart. J Pharmacol Exp Ther 1987;240:657-662.
    • (1987) J Pharmacol Exp Ther , vol.240 , pp. 657-662
    • Iijima, T.1    Taira, N.2
  • 43
    • 0025282302 scopus 로고
    • A placebo-controlled, randomized, double-blind study of OPC-8212 in patients with mild chronic heart failure
    • Sasayama S, for OPC-8212 Multicenter Research Group. A placebo-controlled, randomized, double-blind study of OPC-8212 in patients with mild chronic heart failure. Cardiovasc Drugs Ther 1990;4:19-25.
    • (1990) Cardiovasc Drugs Ther , vol.4 , pp. 19-25
    • Sasayama, S.1
  • 44
    • 0027322458 scopus 로고
    • Effects of vesnarinone of morbidity and mortality in patients with heart failure
    • Feldman AM, for the Vesnarinone Study Group. Effects of vesnarinone of morbidity and mortality in patients with heart failure. N Engl J Med 1993;329:149-155.
    • (1993) N Engl J Med , vol.329 , pp. 149-155
    • Feldman, A.M.1
  • 45
    • 0028106793 scopus 로고
    • Treatment of virus-induced myocardial injury with a novel immunomodulating agent, vesnarinone
    • Matsui S, Matsumori A, Matoba Y, Uchida A, Sasayama S. Treatment of virus-induced myocardial injury with a novel immunomodulating agent, vesnarinone. J Clin Invest 1994; 94:1212-1217.
    • (1994) J Clin Invest , vol.94 , pp. 1212-1217
    • Matsui, S.1    Matsumori, A.2    Matoba, Y.3    Uchida, A.4    Sasayama, S.5
  • 46
    • 0027400621 scopus 로고
    • Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation
    • Lin CS, Boltz RC, Blake JT, et al. Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation. J Exp Med 1993;177: 637-645.
    • (1993) J Exp Med , vol.177 , pp. 637-645
    • Lin, C.S.1    Boltz, R.C.2    Blake, J.T.3
  • 48
    • 0025286817 scopus 로고
    • Elevated circulating levels of tumor necrosis factor in severe chronic heart failure
    • Levine B, Kalman J, Mayer L, Fillit HM, Packer M. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med 1990;323:236-241.
    • (1990) N Engl J Med , vol.323 , pp. 236-241
    • Levine, B.1    Kalman, J.2    Mayer, L.3    Fillit, H.M.4    Packer, M.5
  • 49
    • 0028289439 scopus 로고
    • Mechanisms of immune-mediated myocyte injury
    • Barry WH. Mechanisms of immune-mediated myocyte injury. Circulation 1994;89:2421-2432.
    • (1994) Circulation , vol.89 , pp. 2421-2432
    • Barry, W.H.1
  • 50
    • 0028171632 scopus 로고
    • Increased circulating cytokines in patients with myocarditis and cardiomyopathy
    • Matsumori A, Yamada T, Suzuki H, Matoba Y, Sasayama S. Increased circulating cytokines in patients with myocarditis and cardiomyopathy. Br Heart J 1994;72:561-566.
    • (1994) Br Heart J , vol.72 , pp. 561-566
    • Matsumori, A.1    Yamada, T.2    Suzuki, H.3    Matoba, Y.4    Sasayama, S.5
  • 51
    • 0030159210 scopus 로고    scopus 로고
    • Tumor necrosis factor is expressed in cardiac tissues of patients with heart failure
    • Doyama K, Fujiwara H, Fukumoto M, et al. Tumor necrosis factor is expressed in cardiac tissues of patients with heart failure. Int J Cardiol 1996;54:217-225.
    • (1996) Int J Cardiol , vol.54 , pp. 217-225
    • Doyama, K.1    Fujiwara, H.2    Fukumoto, M.3
  • 52
    • 0028047609 scopus 로고
    • Therapeutic effect of anti-tumor necrosis factor-α antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus
    • Yamada T, Matsumori A, Sasayama S. Therapeutic effect of anti-tumor necrosis factor-α antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus. Circulation 1994;89:846-851.
    • (1994) Circulation , vol.89 , pp. 846-851
    • Yamada, T.1    Matsumori, A.2    Sasayama, S.3
  • 53
    • 0028366498 scopus 로고
    • Inhibition of cytokine production by a new inotropic agent, vesnarinone, in human lymphocytes, T cell line, and monocytic cell line
    • Shioi T, Matsumori A, Matsui S, Sasayama S. Inhibition of cytokine production by a new inotropic agent, vesnarinone, in human lymphocytes, T cell line, and monocytic cell line. Life Sci 1994;54:PL11-16.
    • (1994) Life Sci , vol.54
    • Shioi, T.1    Matsumori, A.2    Matsui, S.3    Sasayama, S.4
  • 54
    • 0028267312 scopus 로고
    • Vesnarinone, a new inotropic agent, inhibits cytokine production by stimulated human blood from patients with heart failure
    • Matsumori A, Shioi T, Yamada T, Matsui S, Sasayama S. Vesnarinone, a new inotropic agent, inhibits cytokine production by stimulated human blood from patients with heart failure. Circulation 1994;89:955-958.
    • (1994) Circulation , vol.89 , pp. 955-958
    • Matsumori, A.1    Shioi, T.2    Yamada, T.3    Matsui, S.4    Sasayama, S.5
  • 55
    • 0028138408 scopus 로고
    • Vesnarinone prolongs survival and reduces lethality in a murine model of lethal endotoxemia
    • Matsui S, Matsumori A, Sasayama S. Vesnarinone prolongs survival and reduces lethality in a murine model of lethal endotoxemia. Life Sci 1994;55:1735-1741.
    • (1994) Life Sci , vol.55 , pp. 1735-1741
    • Matsui, S.1    Matsumori, A.2    Sasayama, S.3
  • 56
    • 0028867876 scopus 로고
    • Inotropic agent vesnarinone inhibits cytokine production and E-selectin expression in human umbilical vein endothelial cells
    • Sato Y, Matsumori A, Sasayama S. Inotropic agent vesnarinone inhibits cytokine production and E-selectin expression in human umbilical vein endothelial cells. J Mol Cell Cardiol 1995;27:2265-2273.
    • (1995) J Mol Cell Cardiol , vol.27 , pp. 2265-2273
    • Sato, Y.1    Matsumori, A.2    Sasayama, S.3
  • 57
    • 0029160682 scopus 로고
    • Vesnarinone inhibits induction of nitric oxide synthase in J774 macrophages and rat cardiac myocytes in culture
    • Hattori Y, So S, Hattori S, Kasai K, Shimoda S. Vesnarinone inhibits induction of nitric oxide synthase in J774 macrophages and rat cardiac myocytes in culture. Cardiovasc Res 1995;30:187-192.
    • (1995) Cardiovasc Res , vol.30 , pp. 187-192
    • Hattori, Y.1    So, S.2    Hattori, S.3    Kasai, K.4    Shimoda, S.5
  • 58
    • 0003146094 scopus 로고
    • Immune modulation of cardiac function: A new frontier
    • Sasayama S. Immune modulation of cardiac function: A new frontier. J Card Failure 1995;1:331-335.
    • (1995) J Card Failure , vol.1 , pp. 331-335
    • Sasayama, S.1
  • 59
    • 0029918974 scopus 로고    scopus 로고
    • Role of cytokines in the syndrome of heart failure
    • Sasayama S, Matsumori A. Role of cytokines in the syndrome of heart failure. Intern Med 1996;35:60-63.
    • (1996) Intern Med , vol.35 , pp. 60-63
    • Sasayama, S.1    Matsumori, A.2
  • 60
    • 0024452170 scopus 로고
    • Calcium-sensitivity modulation of cardiac myofibrillar proteins
    • Ruegg JC, Morano I. Calcium-sensitivity modulation of cardiac myofibrillar proteins. J Cardiovasc Pharmacol 1989; 14(Suppl III):S20-S23.
    • (1989) J Cardiovasc Pharmacol , vol.14 , Issue.3 SUPPL.
    • Ruegg, J.C.1    Morano, I.2
  • 61
    • 0023797004 scopus 로고
    • 2+ activation and the inotropic effect of pimobendan: Comparison with milrinone
    • 2+ activation and the inotropic effect of pimobendan: Comparison with milrinone. Cire Res 1988;63:911-922.
    • (1988) Cire Res , vol.63 , pp. 911-922
    • Fujino, K.1    Sperelakis, N.2    Solaro, R.J.3
  • 62
    • 0024416275 scopus 로고
    • The positive inotropic effect of pimobendan involves stereospecific increases in the calcium sensitivity of cardiac myofilaments
    • Solaro RJ, Fujino K, Sperelakis N. The positive inotropic effect of pimobendan involves stereospecific increases in the calcium sensitivity of cardiac myofilaments. J Cardiovasc Pharmacol 1989;14(Suppl 2):S7-S12.
    • (1989) J Cardiovasc Pharmacol , vol.14 , Issue.2 SUPPL.
    • Solaro, R.J.1    Fujino, K.2    Sperelakis, N.3
  • 63
    • 0024441555 scopus 로고
    • Influence of the positive inotropic substance pimobendan (UD-CG 115 BS) on contractile economy of guinea pig papillary muscles
    • Holubarsch C, Hasenfuss G, Just H, Blanchard E, Mulieri LA, Alpert NR. Influence of the positive inotropic substance pimobendan (UD-CG 115 BS) on contractile economy of guinea pig papillary muscles. J Cardiovasc Pharmacol 1989;14(Suppl II):S13-S17.
    • (1989) J Cardiovasc Pharmacol , vol.14 , Issue.2 SUPPL.
    • Holubarsch, C.1    Hasenfuss, G.2    Just, H.3    Blanchard, E.4    Mulieri, L.A.5    Alpert, N.R.6
  • 64
    • 18844468316 scopus 로고
    • Influence of the calcium-sensitizer UDCG-115 on hemodynamics and myocardial energetics in patients with idiopathic dilated cardiomyopathy. Comparison with nitroprusside
    • Hasenfuss G, Holubarsch C, Heiss HW, Rattert B, Just H. Influence of the calcium-sensitizer UDCG-115 on hemodynamics and myocardial energetics in patients with idiopathic dilated cardiomyopathy. Comparison with nitroprusside. Basic Res Cardiol 1989;84(Suppl I):225-233.
    • (1989) Basic Res Cardiol , vol.84 , Issue.1 SUPPL. , pp. 225-233
    • Hasenfuss, G.1    Holubarsch, C.2    Heiss, H.W.3    Rattert, B.4    Just, H.5
  • 65
    • 0026567057 scopus 로고
    • Beneficial effects of pimobendan on exercise tolerance and quality of life in patients with heart failure: Results of a multicenter trial
    • Kubo SH, for the Pimobendan Multicenter Research Group. Beneficial effects of pimobendan on exercise tolerance and quality of life in patients with heart failure: Results of a multicenter trial. Circulation 1992;85:942-949.
    • (1992) Circulation , vol.85 , pp. 942-949
    • Kubo, S.H.1
  • 66
    • 0028269909 scopus 로고
    • Clinical effects of long-term administration of pimobendan in patients with moderate congestive heart failure
    • Sasayama S, Asanoi H, Kihara Y, et al. Clinical effects of long-term administration of pimobendan in patients with moderate congestive heart failure. Heart Vessels 1994;9: 113-120.
    • (1994) Heart Vessels , vol.9 , pp. 113-120
    • Sasayama, S.1    Asanoi, H.2    Kihara, Y.3
  • 68
    • 0022540094 scopus 로고
    • Cardiovascular profile of pimobendan, a benzimidazole-pyridazinone derivative with vasodilating and inotropic properties
    • Verdouw PD, Hartog JM, Duncker DJ, Roth W, Saxena PR. Cardiovascular profile of pimobendan, a benzimidazole-pyridazinone derivative with vasodilating and inotropic properties. Eur J Pharmacol 1986;126:21-30.
    • (1986) Eur J Pharmacol , vol.126 , pp. 21-30
    • Verdouw, P.D.1    Hartog, J.M.2    Duncker, D.J.3    Roth, W.4    Saxena, P.R.5
  • 69
    • 8044245781 scopus 로고
    • UDCG 115 and 212, two benzimidazo-pyridazinones with broad spectrum antiplatelet activity
    • Arnout J, Deckmyn H, Huybrechts E, Verstraete M. UDCG 115 and 212, two benzimidazo-pyridazinones with broad spectrum antiplatelet activity. Thromb Haemost 1986;54:134.
    • (1986) Thromb Haemost , vol.54 , pp. 134
    • Arnout, J.1    Deckmyn, H.2    Huybrechts, E.3    Verstraete, M.4
  • 70
    • 85024441130 scopus 로고    scopus 로고
    • For the Pimobendan in Congestive Heart Failure (PICO) Investigators: Effect of pimobendan on exercise capacity in patients with heart failure: main results from the PICO trial
    • Just H. For the Pimobendan in Congestive Heart Failure (PICO) Investigators: Effect of pimobendan on exercise capacity in patients with heart failure: main results from the PICO trial. Heart 1996;76:223-231.
    • (1996) Heart , vol.76 , pp. 223-231
    • Just, H.1


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