Substituted 4-aminopiperidines having high in vitro affinity and selectivity for the cloned human dopamine D4 receptor

European Journal of Pharmacology

Volumn 322, Issue 2-3, 1997, Pages 283-286

  Schlachter, Siusaidh K ^a   Poel, Toni J ^a   Lawson, Charles F ^a   Dinh, Dac M ^a   Lajiness, Mary E ^a   Romero, Arthur G ^a   Rees, Susan A ^a   Duncan, J Neil ^a   Smith, Martin W ^a  

^a PFIZER INC   (United States)

Author keywords

Aminopiperidine; Dopamine D4 receptor, human; Receptor binding

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 AMINOPIPERIDINE DERIVATIVE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; CLOZAPINE; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; HALOPERIDOL; LISURIDE; N (1 BENZYL 4 PIPERIDINYL) N (3 ISOPROPOXY 2 PYRIDINYL) N METHYLAMINE; PHENTOLAMINE; PRAZOSIN; QUINPIROLE; RACLOPRIDE; SPIPERONE; U 99363E; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHO CELL; DRUG RECEPTOR BINDING; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY;

AMINOPYRIDINES; ANIMALS; CHO CELLS; CRICETINAE; HUMANS; MITOSIS; PIPERIDINES; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 0030941646     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00013-7     Document Type: Article

References (18)

1. 50) of an enzymatic reaction, Biochem. Pharmacol. 22, 3099.
2. 2 dopamine receptor in rat and bovine caudate nucleus, Nature 343, 266.
3. 2 dopamine receptors, Mol. Pharmacol. 45, 51.
4. 4 dopamine receptor-mediated signalling events determined in trasfected Chinese hamster ovary cells, J. Biol. Chem. 269, 11813.
5. 4 receptors coupled to adenylate cyclase, Proc. Natl. Acad. Sci. USA 89, 12093.
6. 1A receptor, Nature 335, 358.
7. Finney, D.J., 1978, Statistical Methods in Biological Assay (MacMillan, New York, NY) p. 269.
8. 9 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications, Eur. J. Pharmacol. 236, 483.
9. 4 receptor expressed in HEK293 cells, Methods Find. Exp. Clin. Pharmacol. 16, 303.
10. 4 receptor, Eur. J. Pharmacol. 273, R1.
11. 4 antagonist, Soc. Neurosci. Annu. Meeting, Abstr. 252.3.
12. 4 dopamine receptors in baculovirus-infected insect cells, FEBS Lett. 320, 130.
13. 3H]U-91356, J. Label. Compd. Radiopharm. 31, 933.
14. 4 dopamine receptors in postmortem striatum from patients with schizophrenia, J. Neurosci. 15, 2186.
15. 4 receptor: sequence, gene structure, and demonstration of expression in the cardiovascular system, New Biol. 4, 137.
16. 4 receptors bind inactive (+)-aporphines, suggesting neuroleptic role. Sulpiride not stereoselective, Eur. J. Pharmacol. 233, 173.
17. 4 receptor with high affinity for the antipsychotic clozapine, Nature 350, 610.
18. Zawilska, J.B., 1994, The role of dopamine in the regulation of melatonin biosynthesis in vertebrate retina, Acta Neurobiol. Exp. 54 (Suppl.), 47.