AML1a but not AML1b inhibits erythroid differentiation induced by sodium butyrate and enhances the megakaryocytic differentiation of K562 leukemia cells

Cell Growth and Differentiation

Volumn 8, Issue 3, 1997, Pages 319-326

  Niitsu, Nozomi ^a,b   Yamamoto Yamaguchi, Yuri ^a   Miyoshi, Hiroyuki ^c   Shimizu, Kimiko ^c   Ohki, Misao ^c   Umeda, Masanori ^b   Honma, Yoshio ^a  

^a SAITAMA CANCER CENTER   (Japan)

^b TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CELL STRAIN K 562; CONTROLLED STUDY; ERYTHROPOIESIS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MEGAKARYOPOIESIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS;

ANTIGENS, CD; BUTYRIC ACID; BUTYRIC ACIDS; CELL DIFFERENTIATION; CORE BINDING FACTOR ALPHA 2 SUBUNIT; DNA-BINDING PROTEINS; ERYTHROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOPHORIN; HUMANS; LEUKEMIA, MYELOID, CHRONIC; MEGAKARYOCYTES; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0030941411     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Nucifora, G., and Rowely, J. D. AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia. Blood, 86: 1-14, 1995.
2. Erickson, P., Gao, J., Chang, K. S., Look, T., Whisenant, E., Raimondi, S., Lasher, R., Trujillo, J., Rowley, J., and Drabkin, H. Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood, 80: 1825-1831, 1992.
3. Miyoshi, H., Kozu, T., Shimizu, K., Enomoto, K., Maseki, N. Kaneko, Y., Kamada, N., and Ohki, M. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J., 12: 2715-2721, 1993.
4. Daga, A., Tigh, J. E., and Calabi, F. Leukaemia/Drosophila homology. Nature (Lond.), 356: 484, 1992.
5. Miyoshi, H., Ohira, M., Shimizu, K., Mitani, K., Hirai, H., Imai, T., Yokoyama, K., Soeda, E., and Ohki, M. Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia. Nucleic Acids Res., 23: 2762-2769, 1995.
6. Bae, S. C., Yamaguchi-Iwai, Y., Ogawa, E., Maruyama, M., Inuzuka, M., Kagosima, H., Shigesada, K., Satake, M., and Ito, Y. Isolation of PEBP2αA cDNA representing the mouse homolog of acute myeloid leukemia gene AML1. Oncogene, 8: 809-814, 1993.
7. Bae, S. C., Ogawa, E., Maruyama, M., Oka, H., Satake, M., Shigesada, K., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., and Ito, Y. PEBP2αB/ mouse AML1 consists of multiple isoforms that possess differential transcription potential. Mol. Cell. Biol., 14: 3242-3252, 1994.
8. Miyoshi, H., Shimizu, K., Kozu, T., Maseki, N., Kaneko, Y., and Ohki, M. The t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia clustered within a limited region of a novel gene, AML1. Proc. Natl. Acad. Sci. USA, 88: 10431-10434, 1991.
9. Tanaka, T., Tanaka, K., Ogawa, S., Kurokawa, M., Mitani, K., Nishida, J., Shibata, Y., Yazaki, Y., and Hirai, H. An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms. EMBO J., 14: 341-350, 1995.
10. Lozzio, C. B., and Lozzio, B. B. Human chronic myelogenous leukemia cell line with positive Philadelphia chromosome. Blood, 45: 321-334, 1975.
11. Anderson, L. C., Nilsson, K., and Gahmberg, C. G. K562-A human erythroleukemic cell line. Int. J. Cancer, 23: 143-147, 1979.
12. Rowley, P. T., Olsson-Wilhelm, B. M., Farley, B. A., and LaBella, S. Inducers of erythroid differentiation of K562 human leukemia cells. Exp. Hematol., 9: 32-37, 1981.
13. Honma, Y., Okabe-Kado, J., Hozumi, M., Uehara, Y., and Mizuno, S. Induction of erythroid differentiation of K562 human leukemic cells by herbimycin A, an inhibitor of tyrosine kinase activity. Cancer Res., 49: 331-334, 1989.
14. Sato, S., Tomoyasu, S., Okabe-Kado, J., Hozumi, M., Tsuruoka, N., Nakai, S., Adachi, M., and Honma, Y. Induction of differentiation and enhancement of vincristine sensitivity of human erythroleukemia HEL cells by vesnarinone, a positive inotropic agent. Exp. Hematol., 24: 37-42, 1996.
15. Tabilio, A., Pelicci, P. G., Vinci, G., Mannoni, P., Civin, C. I., Vinchenker, W., Testa, U., Lipinski, M., Rochant, H., and Breton-Gorius, J. Myeloid and megakaryocytic properties of K562 cell line. Cancer Res., 43: 4569-4574, 1983.
16. Alitalo, R., Makela, T. P., Koshinen, P., Anderson, L. C., and Alitalo, K. Enhanced expression of transforming growth factor β during megakaryoblastic differentiation of K562 leukemia cells. Blood, 71: 899-906, 1988.
17. Orkin, S. H. GATA-binding transcription factors in hematopoietic cells. Blood, 80: 575-581, 1992.
18. Aplan, P. D., Nakahara, K., Orkin, S. H., and Kirsh, I. R. The SCL gene product: a positive regulator of erythroid differentiation. EMBO J., 11: 4073-4081, 1992.
19. Cheng, T., Wang, Y., and Dai, W. Transcription factor egr-1 is involved in phorbol 12-myristate 13-acetate-induced megakaryocytic differentiation of K562 cells. J. Biol. Chem., 269: 30848-30853, 1994.
20. + human leukemia-derived cell lines. Blood, 84: 1074-1084, 1994.
21. Shimamoto, T., Ohyashiki, J. H., Ohyashiki, K., Kawakubo, K., Kimura, N., Nakazawa, S., and Toyama, K. GATA-1, GATA-2, and stem cell leukemia gene expression in acute myeloid leukemia. Leukemia (Baltimore), 8: 1176-1180, 1994.
22. Suggs, S. V., Katzowitz, J. L., Tsai-Morris, C., and Sukhatme, V. P. cDNA sequence of the human cellular early growth response gene Egr-1. Nucleic Acids Res., 18: 4283, 1990.
23. Prasad, K. N. Butyric acid: a small fatty acid with diverse biological functions. Life Sci., 27: 1351-1358, 1980.
24. Vidali, G., Ferrari, N., and Pfeffer, U. Histone acetylation: a step in gene activation. Adv. Exp. Med. Biol., 231: 583-597, 1988.
25. Candido, E. P., Reeves, R., and Davie, J. R. Sodium butyrate inhibits histone deacetylation in cultured cells. Cell, 14: 105-113, 1978.
26. Loidly, P. Towards an understanding of the biological function of histone acetylation. FEBS Lett., 227: 91-95, 1988.
27. Norton, V. G., Imai, B. S., Yau, P., and Bradbury, E. M. Histone acetylation reduces nucleosome core particle linking number change. Cell, 57: 449-457, 1989.
28. Walker, L., Chen, T. A., Sterner, R., Berger, M., Winston, F., and Allfrey, V. G. Affinity chromatography of mammalian and yeast nucleosomes. J. Biol. Chem., 265: 5736-5746, 1990.
29. Lee, D. Y., Hayes, J. J., Pruss, D., and Woffle, A. P. A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell, 72: 73-84, 1993.
30. Yusta, B., Ortiz-Caro, J., Pascual, A., and Aranda, A. Comparison of the effects of forskolin and dibutyryl cAMP in neuroblastoma cells: evidence that some of the actions of dibutyryl cAMP are mediated by butyrate. J. Neurochem., 57: 1808-1818, 1988.
31. Aviram, A., Zimrah, Y., Shaklai, M., Nudelman, A., and Rephaeli, A. Comparison between the effect of butyric acid and its prodrug pivaloyloxymethylbutyrate on histones hyperacetylation in an HL-60 leukemic cell line. Int. J. Cancer, 56: 906-909, 1994.
32. Toscani, A., Soprano, D. R., and Soprano, K. J. Molecular analysis of sodium butyrate-induced growth arrest. Oncogene Res., 3: 223-238, 1988.
33. Rabizadeh, E., Shaklai, M., Nudelman, A., Eisenbach, L., and Rephaeli, A. Rapid alteration of c-myc and c-jun expression in leukemic cells induced to differentiate by a butyric acid prodrug. FEBS Lett., 328: 225-229, 1993.
34. Sassa, S. Sequential induction of heme pathway enzymes during erythroid differentiation of mouse Friend leukemia virus-infected cells. J. Exp. Med., 143: 305-315, 1976.
35. Guerrasio, A., Saglio, G., Rosso, C., Alfarano, A., Camaschella, C., Coco, F. L., Biondi, A., Rambaldi, A., Nicols, S., and Ottolenghi, S. Expression of GATA-1 mRNA in human myeloid leukemic cells. Leukemia (Baltimore), 8: 1034-1038, 1994.
36. Walters, M., and Martin, D. I. K. Functional erythroid promoters created by interaction of the transcription factor GATA-1 with CACCC and AP-1/NFE-2 elements. Proc. Natl. Acad. Sci. USA, 89: 10444-10448, 1992.
37. Romana, S. P., Mauchauffe, M., Le Coniat, M., Chumakov, I., Le Paslier, D., Berger, R., and Bernard, O. A. The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. Blood, 85: 3662-3670, 1995.
38. Mitani, K., Ogawa, S., Tanaka, T., Miyoshi, H., Kurokawa, M., Mano, H., Yazaki, Y., Ohki, M., and Hirai, H. Generation of the AML1/EVI1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. EMBO J., 73: 504-510, 1994.
39. Tanaka, T., Mitani, K., Kurokawa, M., Ogawa, S., Tanaka, K., Nishida, J., Yazaki, Y., Shibata, Y., and Hirai, H. Dual functions of the AML1/Evi-1 chimeric protein in the mechanism of leukemogenesis in t(3;21) leukemias. Mol. Cell. Biol., 75: 2383-2392, 1995.
40. Eckner, R., Ewen, M. E., Newsome, D., Gerdes, M., Decaprio, J. A., Lawrence, J. B., and Livingston, D. M. Molecular cloning and functional analysis of the adenovirus E1A - associated 300 kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev., 8: 869-884, 1994.
41. Robertson, N. M., Bodine, P. V. N., Hsu, T. C., Alnemri, E. S., and Litwack, G. Modulator inhibits nuclear translocation of the glucocorticoid receptor and inhibits glucocorticoid-induced apoptosis in the human leukemic cell line DEM C-7. Cancer Res., 55: 548-556, 1995.
42. Kozu, T., Miyoshi, H., Shimizu, K., Maseki, N., Kaneko, Y., Asou, H., Kamada, N., and Ohki, M. Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction. Blood, 82: 1270-1276, 1993.
43. Laemmli, U. K. Cleavage of structure proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227: 680-685, 1970.
44. Kanatani, Y., Kasukabe, T., Hozumi, M., Motoyoshi, K., Nagata, N., and Honma, Y. Genistein exhibits preferential cytotoxicity to a leukemogenicity to a leukemogenic variant but induces differentiation of a nonleukemogenic variant of the mouse monocytic leukemia Mm cell line. Leukemia Res., 17: 847-853, 1993.