Discovery of selective, small-molecule inhibitors of RNA complexes - II. Self-splicing group I intron ribozyme

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 6, 1997, Pages 1185-1195

  Mei, Houng Yau ^a   Cui, Mei ^a   Lemrow, Shannon M ^a   Czarnik, Anthony W ^a,b  

^a PFIZER INC   (United States)

^b IRORI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; RIBOZYME; RNA PRECURSOR;

CONFERENCE PAPER; ENZYME ACTIVITY; ENZYME REGULATION; INTRON; NONHUMAN; PNEUMOCYSTIS CARINII; RNA CLEAVAGE; SCREENING; TECHNIQUE;

BACTERIOPHAGE T4; BASE SEQUENCE; ENZYME INHIBITORS; INTRONS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PNEUMOCYSTIS; RNA; RNA PRECURSORS; RNA SPLICING; RNA, CATALYTIC; RNA, FUNGAL; RNA, VIRAL;

PNEUMOCYSTIS CARINII;

EID: 0030940946     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(97)00065-5     Document Type: Conference Paper

References (25)

1. Cech, T. R. Gene 1993, 135, 33.
2. (a) Cech, T. R. Bio/Technology 1995, 13, 323.
3. (b) Altman, S. Bio/Technology 1995, 13, 327.
4. Christoffersen, R. E.; Marr, J. J. J. Med. Chem. 1995, 38, 2023.
5. von Ahsen, U.; Davies, J.; Schroeder, R. Nature (London) 1991, 353, 368.
6. Cech, T. R. Annu. Rev. Biochem. 1990, 59, 543.
7. Michel, F.; Westhof, E. J. Mol. Biol. 1990, 216, 585.
8. Saldanha, R. J.; Patel, S. S.; Surendran, R.; Lee, J. C.; Lambowitz, A. M. Biochemistry 1995, 34, 1275.
9. Taylor, J. Annu. Rev. Microbiol. 1992, 46, 253.
10. Liu, Y.; Leibowitz, M. J. Nucleic Acids Res. 1995, 23, 1284.
11. (a) Bass, B. L.; Cech, T. R. Biochemistry 1986, 25, 4473.
12. (b) Yarus, M. Science 1988, 240, 1751.
13. von Ahsen, U.; Davies, J.; Schroeder, R. J. Mol. Biol. 1992, 226, 935.
14. The therapeutic application of ribozyme inhibitors of peptide, nucleic acid, or aminoglycoside-like molecules have been reported previously in: (a) Cech, T. R. (1991) PCT Int. Appl. 38 pp. CODEN: PIXXD2. WO 9106302 A1 910516.
15. (b) von Ahsen, U.; Davies, J.; Schroeder, R. (1993) PCT Int. Appl., 18 pp CODEN: PIXXD2. WO 9300907 A1 930121.
16. Lin, H.; Niu, M. T.; Yoganathan, T.; Buck, G. A. Gene 1992, 119, 163.
17. Doudna, J. A.; Couture, S.; Szostak, J. W. Science 1991, 256, 1605.
18. Barrett, J. F.; Ohemeng, K. A. Expert Opin. Invest. Drugs 1994, 3, 303.
19. For the sake of clarity, we did not distinguish the two longer RNA products (5′-guanine-439-nt and 5′-guanine-390-nt) from their original RNA fragments. Regardless of the incorporation of a guanosine, 439-nt and 390-nt were always used to represent these two RNA fragments, respectively.
20. (a) Wank, H.; Rogers, J.; Davies, J.; Schroeder, R. J. Mol. Biol. 1994, 236, 1001.
21. (b) Liu, Y.; Tidwell, R. R.; Leibowitz, M. J. J. Euk. Microbiol. 1994, 41, 31.
22. phe. The effects of carriers on the inhibitory activities of compounds 1-3 were not significant. Compared to the data obtained using nonradioactive precursor RNA, the discrepancy might result from the different conditions of these experiments.
23. Bass, B. L.; Cech, T. R. Nature (London) 1984, 308, 820.
24. Green, N. M. In Methods in Enzymol.; Bayer, E. A.; Wilchek, M., Eds; Academic: 1990; Vol. 184, p 51.
25. Uderfriend, S., Gerber, L., Nelson, N. Anal. Biochem. 1987, 161, 494.