Improved cost-effectiveness by pharmacokinetic dosing of factor VIII in prophylactic treatment of haemophilia A

Haemophilia

Volumn 3, Issue 2, 1997, Pages 96-101

  Carlsson, M ^a   Berntorp, E ^a   Bjorkman S ^a   Lethagen, S ^a   Ljung, R ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cost effectiveness; Dosage; Factor VIII; Haemophilia A; Pharmacokinetics; Prophylaxis

Indexed keywords

BLOOD CLOTTING FACTOR 8;

ADOLESCENT; ADULT; ARTICLE; BLEEDING; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; CROSSOVER PROCEDURE; DRUG HALF LIFE; HEMOPHILIA A; HUMAN; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD;

EID: 0030940593     PISSN: 13518216     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2516.1997.00091.x     Document Type: Article

References (9)

1. Ahlberg Å. Haemophilia in Sweden; VII. Incidence, treatment and prophylaxis of arthropathy and other musculoskeletal manifestations of haemophilia A and B. Acta Ortop Scand 1965; (Suppl. 77): 7-80.
2. Nilsson IM, Berntorp E, Löfqvist T, Pettersson H. Twentyfive years' experience of prophylactic treatment in severe haemophilia A and B. J Int Med 1992; 232: 25-32.
3. Matucci M, Messori A, Donati-Cori G, et al. Kinetic evaluation of four factor VIII concentrates by model-independent methods. Scand J Haematol 1985; 34: 22-8.
4. Messori A, Longo G, Matucci M, Morfini M, Rossi Ferrini PL. Clinical pharmacokinetics of factor VIII in patients with classic haemophilia. Clin Pharmacokin 1987; 13: 365-80.
5. Messori A, Longo G, Morfini M. et al. Multi-variate analysis of factors governing the pharmacokinetics of exogenous factor VIII in haemophiliacs. Eur J Clin Pharmacol 1988; 35: 663-8.
6. Björkman S, Carlsson M, Berntorp E, Stenberg P. Pharmacokinetics of factor VIII in humans - obtaining clinically relevant data from comparative studies. Clin Pharmacokin 1992; 22: 385-95.
7. Carlsson M, Berntorp E, Björkman S, Lindvall K. Pharmacokinetic dosing in prophylactic treatment of hemophilia A. Eur J Haematol 1993; 51: 247-52.
8. Rosén S. Assay of factor VIII:C with a chromogenic substrate. Scand J Haematol 1984; 33 (Suppl. 40): 139-45.
9. Larsson SA, Wiechel B. Deaths in Swedish hemophiliacs, 1957-1980. Acta Med Scand 1983; 214: 199-206.