Peptides and neuromas: Calcitonin gene-related peptide, substance P, and mast cells in a mechanosensitive human sural neuroma

Muscle and Nerve

Volumn 20, Issue 7, 1997, Pages 875-880

  Zochodne, Douglas W ^a   Theriault, Michele ^a   Sharkey, Keith A ^a   Cheng, Chu ^a   Sutherland, Garnette ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Neuropeptides; Pain; Peripheral nerve injury

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; LEVACECARNINE; NEUROPEPTIDE; SEROTONIN; SUBSTANCE P; TYROSINE 3 MONOOXYGENASE;

ADULT; ARTICLE; CASE REPORT; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETIC NEUROPATHY; DOUBLE BLIND PROCEDURE; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; MALE; MAST CELL; MECHANORECEPTOR; MULTICENTER STUDY; NERVE BIOPSY; NEUROMA; NOCICEPTION; ORAL DRUG ADMINISTRATION; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SURAL NERVE;

ANTIBODY SPECIFICITY; BIOPSY; CALCITONIN GENE-RELATED PEPTIDE; DOUBLE-BLIND METHOD; HUMANS; MALE; MAST CELLS; MECHANORECEPTORS; MIDDLE AGED; MULTICENTER STUDIES; MYELIN SHEATH; NEUROMA; NEURONS; PAIN; PERIPHERAL NERVOUS SYSTEM NEOPLASMS; RANDOMIZED CONTROLLED TRIALS; SUBSTANCE P; SURAL NERVE; TYROSINE 3-MONOOXYGENASE;

EID: 0030939332     PISSN: 0148639X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4598(199707)20:7<875::AID-MUS12>3.0.CO;2-R     Document Type: Article

References (17)

1. Arvidsson U, Johnson H, Piehl F, Cullheim S, Hokfelt T, Risling M, Terenius L, Ulfhake B: Peripheral nerve section induces increased levels of calcitonin gene-related peptide (CGRP)-like immunoreactivily in axotomized motoneurons. Exp Brain Res 1990;79:212-216.
2. Biella G, Panara C, Pecile A, Sotgiu ML: Facilitatoiy role of calcitonin gene-related peptide (CGRP) on excitation induced by substance P (SP) and noxious stimuli in rat spinal dorsal horn neurons. An iontophoretic study in vivo. Brain Res 1991;559:352-356.
3. Brain SD, Williams TJ, Tippins JR, Morris HR, MacIntyre I: Calcitonin gene-related peptide is a potent vasodilator. Nature 1985;313:54-56.
4. Caldero J, Casanovas A, Sorribas A, Esquerda JE: Calcitonin gene-related peptide in rat spinal cord motoneurons: subcellular distribution and changes induced by axotomy. Neuroscience 1992;48:449-461.
5. Cheng L, Khan M, Mudge AW: Calcitonin gene-related peptide promotes Schwann cell proliferation. Cell Biol 1995;129: 789-796.
6. Devor M, Keller CH, Deerinck TJ, Levinson SR, Ellisman MH: Na+ channel accumulation on axolemma of afferent endings in nerve and neuromas in Apteronotus. Neurosci Lett 1989;102: 149-154.
7. Devor M, Govrin-Lippmann R, Angelides K: Na+ channel immunolocalization in peripheral mammalian axons and changes following nerve injury and neuroma formation. J Neurosci 1993;13:1976-1992.
8. Devor M, Janig W: Activation of myelinated afferents ending in a neuroma by stimulation of the sympathetic supply in the rat. Neurosci Lett 1981;24:43-47.
9. Devor M, Wall PD, Catalan N: Systemic Iidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction. Pain 1992;48:261-268.
10. Donnerer J, Schuligoi R, Stein C: Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: evidence for a regulatory function of nerve growth factor in vivo. Neuroscience 1992;49:693-698.
11. Dumoulin FL, Raivich G, Streit WJ, Kreutzberg GW: Differential regulation of calcitonin gene-related peptide (CGRP) in regenerating rat facial nucleus and dorsal root ganglion. Eur J Neursci 1991;3:338-342.
12. Dumoulin FL, Raivich G, Haas CA, Lazar P, Reddington M, Streit WJ, Kreutzberg GW: Calcitonin gene-related peptide and peripheral nerve regeneration. Ann NY Acad Sci 1992;657: 351-360.
13. England JD, Gamboni F, Ferguson MA, Levinson SR: Sodium channels accumulate at the tips of injured axons. Muscle Nerve 1994;17:593-598.
14. Fried K, Govrin-Lippmann R, Devor M: Close apposition among neighbouring axonal endings in a neuroma. J Neurocyrol 1993;22:663-681.
15. Hanesch V, Pfrommer V, Grubb BD, Heppelmann B, Schaible HG: The proportion of CGRP-immunoreactive and SP-mRNA containing dorsal root ganglion cells is increased by a unilateral inflammation of the ankle joint of the rat. Regul Pept 1993;46:202-203.
16. Holzer P: Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 1988;24:739-768.
17. Lembeck F: Sir Thomas Lewis's nocifensor system, histamine and substance P containing primary afferent nerves. Trends Neurosci 1983;6:106-108.