Oral naloxone antagonizes morphine-induced constipation;Aufhebung einer Morphin-induzierten Obstipation durch orales Naloxon

Anaesthesist

Volumn 46, Issue 3, 1997, Pages 191-194

  Latasch, L ^a   Zimmermann, M ^b   Eberhardt, B ^c   Jurna, I ^d  

^a KRANKENHAUS NORDWEST   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^c Universität des Saarlandes ^*

^d SAARLAND UNIVERSITY   (Germany)

Author keywords

analgesia; constipation; morphine induced; ora naloxone

Indexed keywords

MORPHINE; NALOXONE;

ANALGESIC ACTIVITY; ARTICLE; CASE REPORT; CONSTIPATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG EFFICACY; HUMAN; INTESTINE MOTILITY; PAIN ASSESSMENT;

AGED; ANALGESICS, OPIOID; CATHARTICS; CONSTIPATION; FEMALE; HUMANS; MALE; MIDDLE AGED; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; PAIN MEASUREMENT; PAIN, POSTOPERATIVE;

EID: 0030939176     PISSN: 00032417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001010050390     Document Type: Article

References (13)

1. Culpepper-Morgan JA, Inturrisi CE, Portenoy RK, Foley K, Houde RW, Marsh F, Kreek MJ (1992) Treatment of opioid-induced constipation with oral naloxone: a pilot study. Clin Pharmacol Ther 52:90-95
2. 3H in normal and narcotic-dependent men. J Pharmacol Exp Ther 187:575-580
3. Forth W, Rummel W (1992) Laxantien. Pharmakotherapie der Obstipation. In: Forth W, Rummel W, Henschler D, Starke K (Hrsg) Allgemeine und spezielle Pharmakologie und Toxikologie. BI Wissenschaftsverlag, Mannheim Leipzig Wien, S 483-490
4. Jurna I, Kaiser R, Kretz O, Baldauf J (1992) Oral naloxone reduces constipation but not antinociception from oral morphine in the rat. Neurosci Lett 142:62-64
5. Konturek SJ, Thor P, Król R, Dembinski A, Schally AV (1980) Influence of methionine-enkephalin and morphine on myoelectric activity of small bowel. Am J Physiol 238:G384-G389
6. Kromer W (1993) Gastrointestinal effects of opioids. In: Herz A (ed) Opioids II. Handbook of Experimental Pharmacology, vol 104/II, pp 163-190
7. Latasch L, Jurna I, Zimmermann M, Eberhardt B (1996) The antagonization of opioid-induced obstipation by naloxone. Dolor Investigación, Clinica Therapéutica [Suppl I] 11:47
8. Manara L, Bianchetti A (1985) The central and peripheral influences of opioids on gastrointestinal propulsion. Annu Rev Pharmacol Toxicol 25:249-273
9. Portenoy RK (1987) Constipation in the cancer patient: causes and management. Med Clin North Am 71:303-311
10. Robinson BA, Johansson L, Shaw J (1991) Oral naloxone in opioid-associated constipation. Lancet 1:581-582
11. Sykes NP (1991) Oral naloxone in opioid-associated constipation. Lancet 11:1475
12. Tavani A, Bianchetti G, Ferretti P, Manara L (1980) Morphine is most effective on gastrointestinal propulsion in rats by intraperitoneal route: evidence for local action. Life 5027:2211-2217
13. Weinstein SH, Pfeffer M, Shor JM, Franklin L, Mintz M, Tutko ER (1973) Absorption and distribution of naloxone in rats after oral and intravenous administration. J Pharm Sci 62:1416-1419