The molecular biology of proliferative senescence;Die molekularen Mechanismen der Seneszenz in Zellkultur

Zeitschrift fur Gerontologie und Geriatrie

Volumn 30, Issue 1, 1997, Pages 24-28

  Von Zglinicki, T ^a   Saretzki, G ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

cell immortalization; cellular senescence; Hayflick limit; telomerase; telomeres

Indexed keywords

TELOMERASE;

ARTICLE; CANCER; CELL DIVISION; CELL PROLIFERATION; CELL TRANSPLANTATION; GENETIC DISORDER; HUMAN; MOLECULAR BIOLOGY; OXIDATIVE STRESS; SENESCENCE;

AGED; CELL AGING; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; DNA DAMAGE; DNA REPLICATION; HUMANS; MODELS, GENETIC; REACTIVE OXYGEN SPECIES; TELOMERE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0030939143     PISSN: 0044281X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW, Harley CB (1992) Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 89:10114-10118
2. Allsopp RC, Chang E, Kashefi-Aazam M, Rogaev EI, Piatyszek MA, Shay JW, Harley CB (1995) Telomere shortening is associated with cell division in vitro and in vivo. Exp Cell Res 220:194-200
3. Atadja P, Wong H, Garkavtsev I, Veillette C, Riabowol K (1995) Increased activity of p53 in senescing fibroblasts. Proc Natl Acad Sci USA 92:8348-8352
4. Balin AK, Goodman DBP, Rasmussen H, Cristofalo VJ (1978) Oxygen-sensitive stages of the cell cycle of human diploid cells. J Cell Biol 78:390-400
5. Blackburn EH, Szostak JW (1984) The molecular structure of centromeres and telomeres. Annu Rev Biochem 53:163-194
6. Bond JA, Wyllie S, Wynford-Thomas D (1994) Escape from senescence in human diploid fibroblasts induced directly by mutant p53. Oncogene 9:1885-1889
7. Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR (1995) Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 14:4240-4248
8. Chadeneau C, Hay K, Hirte HW, Gallinger S, Bacchetti S (1995) Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Cancer Res 55:2533-2536
9. Chen Q, Fischer A, Reagan JD, Yan LJ, Ames BN (1995) Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc Natl Acad Sci USA 92:4337-4341
10. Fraga CG, Shigenaga MK, Park JW, Degan P, Ames BN (1990) Oxidative damage to DNA during aging: 8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci USA 87:4533-4537
11. Goldstein S (1990) Replicative senescence: the human fibroblast comes of age. Science 249:1129-1133
12. Hainaut P (1995) The tumor suppressor protein p53: a receptor to genotoxic stress that controls cell growth and survival. Curr Opin Oncol 7:76-82
13. Harley CB (1991) Telomere loss: mitotic clock or genetic time bomb? Mut Res 256:271-282
14. Harley CB, Futcher AB, Greider CW (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345:458-460
15. Hayflick L (1984) Intracellular determinants of cell aging. Mech Ageing Developm 28:177-185
16. Hayflick L, Moorhead PS (1961) The serial cultivation of human diploid strains. Exp Cell Res 25:585-621
17. Hensler PJ, Pereira-Smith OM (1995) Human replicative senescence. A molecular study. Am J Pathol 147:1-8
18. Hiyama E, Hiyama K, Yokoyama T, Matsuura Y, Piatyszek MA, Shay JW (1995) Correlating telomerase activity levels with human neuroblastoma outcomes. Nature Medicine 1:249-255
19. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PLC, Coviello GM, Wright WE, Weinrich SL, Shay JW (1995) Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011-2015
20. Kipling D (1995) The telomere. Oxford University Press, Oxford, pp 31-77
21. Lindsey J, McGill NI, Lindsey LA, Green DK, Cooke HJ (1991) In vivo loss of telomeric repeats with age in humans. Mut Res 256:45-48
22. Nelson WG, Kastan MB (1994) DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol Cell Biol 14:1815-1823
23. Noda A, Ning Y, Venabale SF, Pereira-Smith OM, Smith JR (1994) Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 211:90-98
24. Olovnikov AM (1973) A theory of marginotomy. J Theor Biol 41:181-190
25. Packer L, Fuehr K (1977) Low oxygen concentration extends the lifespan of cultured human diploid cells. Nature 267:423-425
26. Poot M (1991) Oxidants and antioxidants in proliferative senescence. Mutat Res 256:177-189
27. Rivier DH, Pillus L (1994) Silencing speaks up. Cell 76:963-966
28. Wynford-Thomas D, Bond JA, Wyllie FS, Jones CJ (1995) Does telomere shortening drive selection for p53 mutation in human cancer? Molec Carcinogenesis 12:119-123
29. von Zglinicki T, Schewe C (1995) Mitochondrial water loss and aging of cells. Cell Biochem Funct 13:181-187
30. von Zglinicki T, Saretzki G, Döcke W, Lotze C (1995) Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res 220:186-193