The utility of enzymes in generating molecular diversity. Lipase mediated amidation of polybenzyl esters

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 8, 1997, Pages 1027-1030

  Adamczyk, Maciej ^a   Gebler, John C ^a   Grote, Jonathan ^a  

^a ABBOTT DIAGNOSTICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; TRIACYLGLYCEROL LIPASE;

ARTICLE; BURKHOLDERIA CEPACIA; DRUG SYNTHESIS; ENZYME ACTIVITY; IN VITRO STUDY; MASS SPECTROMETRY; METHODOLOGY;

EID: 0030938870     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00147-9     Document Type: Article

References (11)

1. Van der Meer, J.T.M.; Drew, W.L.; Bowden, R.A.; Galasso, G.J.; Griffiths, P. Antivir. Res. 1996, 32, 119.
2. Boehme, R.E.; Borthwick, A.D.; Wyatt, P.G. Ann. Rep. Med. Chem. 1995, 30, 139.
3. De Clercq, E. Rev. Med. Virol. 1995, 5, 149.
4. Field, A.K.; Biron, K.K. Clin. Microbiol. Rev. 1994, 7, 1.
5. Esteban, A.I.; Juanes, O.; Conde, S.; Goya, P.; De Clercq, E.; Martinez, A. Bioorg. Med. Chem. 1995, 3, 1527.
6. Esteban, A.I.; De Clercq, E.; Martinez, A. Presented at First International Symposium on New Horizons of Organic Chemistry in Biomedicine, Santiago de Compostela (Spain), 1996.
7. Vorbrüggen, H.; Niedballa, U. J. Org. Chem. 1974, 39, 3664.
8. 2O was added under vigorous stirring and exclusion of moisture. The resulting mixture was stirred at room temperature for 1 to 3 hours, and then was worked up in each particular case.
9. De la Cruz, A.; Elguero, J.; Gotor, V.; Goya, P.; Martinez, A.; Moris, F. Synth. Commun. 1991, 21, 1477.
10. Esteban, A.I.; Juanes, O.; Conde, S.; Martinez, A. Tetrahedron, 1994, 48, 13865.
11. De Clercq, E., in Minutes of an European Symposium, Editors: D. Crommelin, P. Couvreur and D. Duchene, Editions de Santé, Paris, France 1994, pp 108.