Enzymatic determination of carnitine in milk and infant formula

Food Chemistry

Volumn 59, Issue 3, 1997, Pages 325-332

  Woollard, David C ^a   Indyk, Harvey E ^b   Woollard, Gerald A ^c  

^a Ministry of Agriculture   (New Zealand)

^b FONTERRA RESEARCH CENTRE   (New Zealand)

^c AUCKLAND CITY HOSPITAL   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLCARNITINE; ANION; CARNITINE; CARNITINE ACETYLTRANSFERASE; ESTER;

ARTICLE; ARTIFICIAL MILK; AUTOMATION; CHROMATOPHORE; ENZYMATIC ASSAY; HYDROLYSIS;

EID: 0030938812     PISSN: 03088146     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0308-8146(96)00327-5     Document Type: Article

References (47)

1. Arakawa, N., Ha, T. Y. & Otsuka, M. (1989). An improved high-performance liquid chromatographic assay for the determination of free and esterified carnitine in animal tissues. J. Nutr. Sci. Vitaminol., 35, 475-479.
2. Baker, H., DeAngelis, B., Baker, E. R., Reddi, A. S., Khalil, M. & Frank, O. (1992). Routine microbiological assay for carnitine activity in biological fluids and tissues. Food Chem., 43, 141-146.
3. Bieber, L. L. & Lewin, L. M. (1981). Measurement of carnitine and O-acylcarnitines. Methods Enzymol., 72, 276-287.
4. Bieber, L. L. & Kerner, J. (1986). Short-chain acylcarnitines: identification and quantitation. Methods Enzymol., 123, 264-276.
5. Bieber, L. L. (1988). Carnitine. Am. Rev. Biochem., 57, 261-283.
6. Borum, P. R., Broquist, H. P. & Roelofs, R. I. (1977). Muscle carnitine levels in neuromuscular disease. J. Neurol. Sci., 34, 279-286.
7. Borum, P. R., York, C. M. & Broquist, H. P. (1979). Carnitine content of liquid formulas and special diets. Am. J. Clin. Nutr., 32, 2272-2276.
8. Borum, P. R. (1983). Carnitine. Ann. Rev. Nutr., 3, 233-259.
9. Borum, P. R. (1990). Carnitine: determination of total carnitine using a radioenzymatic assay. J. Nutr. Biochem., 1, 111-114.
10. Borum, P. R. (1991). Carnitine. In Handbook of Vitamins, 2nd Edn., L. Machlin (Ed). Marcel Dekker Inc., NY., pp. 557-563.
11. Bosi, G. & Refrigeri, M. S. (1983). Determinazione gascromatografica della carnitina nel latte. Rassegna Chim., 35, 421-426.
12. Bremer, J. (1983). Carnitine metabolism and function. Physiol. Rev., 63, 1420-1468.
13. Cederblad, G. & Lindstedt, S. (1972). A method for the determination of carnitine in the picomole range. Clin. Chim. Acta., 37, 235-243.
14. De Sousa, C., English, N. R., Stacey, T. E. & Chalmers, R. A. (1990). Measurement of L-carnitine and acylcarnitines in body fluids and tissues in children and in adults. Clin. Chim. Acta., 187, 317-328.
15. De Witt, P., Deias, R., Muck, S., Galletti, B., Meloni, D., Celletti, P. & Marzo, A. (1994). High-performance liquid chromatography and capillary electrophoresis of L- and D-carnitine by precolumn diastereomeric derivatisation. J. Chromatogr. B, 657, 67-73.
16. Erfle, J. D., Fisher, L. J. & Sauer, F. (1970). Carnitine and acetylcarnitine in the milk of normal and ketotic cows. J. Dairy Sci., 53, 486-489.
17. Feller, A. G. & Rudman, D. (1988). Role of carnitine in human nutrition. J. Nutr., 118, 541-547.
18. Hamamoto, M., Shimoda, K., Matsuura, N. & Matsuura, H. (1988a). Determination of free-, short-chain acyl and long-chain acyl carnitines in milk and milk products. J. Jap. Soc. Nutr. Food Sci., 41, 397-404.
19. Hamamoto, M., Shimoda, K., Matsuura, N. & Matsuura, H. (1988b). A method for the fractionation and determination of carnitines in milk and milk products. J. Jap. Soc. Nutr. Food Sci., 41, 389-395.
20. Hirota, T., Minato, K., Ishii, K., Nishimura, N. & Sato, T. (1994). High-performance liquid chromatographic determination of enantiomers of carnitine and acetylcarnitine on a chiral stationary phase. J. Chromotogr. A, 673, 37-43.
21. Indyk, H. E. & Woollard, D. C. (1995). Enzymatic determination of free carnitine in milk and infant formula. J. AOAC International, 78, 69-74.
22. Kamata, K., Takahashi, M., Terasima, K. & Nishijima, M. (1994). Liquid chromatographic determination of carnitine by precolumn derivatisation with pyrene-1-carbonyl cyanide. J. Chromatogr. A, 667, 113-118.
23. Kamimori, H., Hamashima, Y. & Konishi, M. (1994). Determination of carnitine and saturated-acyl group carnitines in human urine by high-performance liquid chromatography with fluorescence detection. Anal. Biochem., 218, 417-424.
24. Kerner, J., Froseth, J. A., Miller, E. R. & Bieber, L. L. (1984). A study of the acylcarnitine content of sows colostrum, milk and newborn piglet tissues: demonstration of high amounts of isovalerylcarnitine in colostrum and milk. J. Nutr., 114, 854-861.
25. Kumps, A., Duez, P. & Mardens, Y. (1994). Gas chromatographic profiling and determination of urinary acylcarnitines. J. Chromatogr. B., 658, 241-248.
26. La Count, D. W., Drackley, J. K. & Weigel, D. J. (1995). Responses of dairy cows during early lactation to ruminai or abomasal administration of L-carnitine. J. Dairy Sci., 78, 1824-1836.
27. Lowes, S. & Rose, S. (1989). Analytical procedures for determining acylcarnitines in biological fluids. Tr. Anal. Chem., 8(5), 184-188.
28. Marquis, N. R. & Fritz, I. B. (1964). Enzymological determination of free carnitine concentrations in rat tissues. J. Lipid Res., 5, 184-187.
29. Marzo, A., Cardace, G., Monti, N., Muck, S. & Martelli, E. A. (1990). Chromatographic and non-chromatographic assay of L-carnitine family components. J. Chromatogr. Biomed. Appns., 527, 247-258.
30. Matsumoto, K., Ichitani, Y., Ogasawara, N., Yuki, H. & Imai, K. (1994). Precolumn fluorescence derivatisation of carnitine and acylcarnitine with 4-(2-aminoethylamino)-7-nitro-2,1,3-benzoxadiazole prior to high-performance liquid chromatography. J. Chromatogr. A, 678, 241-247.
31. McGarry, J. D. & Foster, D. W. (1976). An improved and simplified radioisotopic assay for the determination of free and esterified carnitine. J. Lipid Res., 17, 277-281.
32. Minkler, P. E. & Hoppel, C. L. (1993). Quantification of carnitine and specific acylcarnitines by high performance liquid chromatography: application to normal human urine and urine from patients with methylmalonic aciduria, isovaleric acidemia or medium-chain acyl-CoA dehydrogenase deficiency. J. Chromatogr. Biomed. Appns., 613, 203-221.
33. Mitchell, M. E. (1978). Carnitine metabolism in human subjects. I. Normal metabolism. Am. J. Clin. Nutr., 31, 293-306.
34. Ohtani, Y., Higashi, A. & Matsuda, I. (1985). Carnitine concentration of formulas. J. Pediatr. Gastroenterol Nutr., 4, 845-846.
35. Pace, J. A., Wannemacher, R. W. & Neufeld, H. A. (1978). Improved radiochemical assay for carnitine and its derivatives in plasma and tissue extracts. Clin. Chem., 24, 32-35.
36. Parvin, R. & Pande, S. V. (1977). Microdetermination of (-)carnitine and carnitine acetyltransferase activity. Anal. Biochem., 79, 190-201.
37. Rebouche, C. J. & Paulson, D. J. (1986). Carnitine metabolism and function in humans. Ann. Rev. Nutr., 6, 41-66.
38. Rebouche, C. J. (1988). Carnitine metabolism and human nutrition. J. Appl. Nutr., 40, 99-111.
39. Roe, D. S., Terada, N. & Millington, D. S. (1992). Automated analysis for free and short-chain acylcarnitine in plasma with a centrifugal analyzer. Clin. Chem., 38, 2215-2220.
40. Roos, von N., de Vrese, M., Schulte-Coerne, H. & Barth, C. A. (1990). L-Carnitin in Milch von Monozygoten Zwillingskuhen. Kieler Milchwirtschaftliche Forschungsberichte, 44(4), 363-370.
41. Rossle, C., Kohse, K. P., Franz, H.-E. & Furst, P. (1985). An improved method for the determination of free and esterified carnitine. Clin. Chim. Acta, 149, 263-268.
42. Seccombe, D. W., Dodek, P., Frohlich, J., Hahn, P., Skala, J. P. & Campbell, D. J. (1976). Automated method for L-carnitine determination. Clin. Chem., 22, 1589-1592.
43. Sandor, A., Pecsuvac, K., Kerner, J. & Alkonyi, I. (1982). On carnitine content of the human breast milk. Pediatr. Res., 16, 89-91.
44. Schmidt-Sommerfeld, E., Zhang, L., Bobrowski, P. J. & Penn, D. (1995). Quantitation of short- and medium-chain acylcarnitines in plasma by radioisotopic exchange/high-performance liquid chromatography. Anal. Biochem., 231, 27-33.
45. Takahashi, M., Ueda, S., Misaki, H., Sugiyama, N., Matsumoto, K., Matsuo, N. & Murao, S. (1994). Carnitine determination by an enzymatic cycling method with carnitine dehydrogenase. Clin. Chem., 40, 817-821.
46. Takeyama, N., Takagi, D., Adachi, K. & Tanaka, T. (1986). Measurement of free and esterified carnitine in tissue extracts by high-performance liquid chromatography. Anal. Biochem., 158, 346-354.
47. Van Kempen, T. A. T. G. & Odle, J. (1992). Quantitation of carnitine esters by high-performance liquid chromatography. Effect of medium-chain triglycerides on the plasma carnitine ester profile. J. Chromatogr. Biomed. Appns., 584, 157-165.