Sustained release characteristics and pharmacokinetic parameters of ketoprofen suppositories using chitosan

International Journal of Pharmaceutics

Volumn 147, Issue 1, 1997, Pages 71-77

  Tarimci, Nilüfer ^a   Ermiş, Dilek ^a  

^a ANKARA UNIVERSITY   (Turkey)

Author keywords

Chitosan; In vivo release; Ketoprofen; Pharmacokinetics; Rabbit; Rectal administration; Sustained release suppository

Indexed keywords

CHITOSAN; KETOPROFEN; MACROGOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG GRANULE; DRUG RELEASE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RECTAL DRUG ADMINISTRATION; SUPPOSITORY; SUSTAINED RELEASE FORMULATION;

EID: 0030937946     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(96)04790-4     Document Type: Article

References (17)

1. Aǧabeyoǧlu, I.T., 'DISSOL': Un programme dans la langue basique demicrocomputer pour la demirmination des donnéés de dissolution, XVIII, é semaine médicale Balkanique, Istanbul. 30 August 2 September 1984. Abstracts 327.
2. Brown, R.D. and Manno, J.E., ESTRIP, a BASIC computer program for obtaining initial polyexponential parameter estimates. J. Pharm. Sci., 67 (1978) 1687-1691.
3. Ermiş, D. and Tarimci, N., Ketoprofen sustained release suppositories containing hydroxypropylmethylcellulose phthalate in polyethyleneglycol bases. Int. J. Pharm., 113 (1995) 65-71.
4. Ermiş, D. and Tarimci, N., Sustained release suppositories of ketoprofen using chitosan, Ist Eur. Congr. Pharmaceutical Sciences, 7 - 9 October 1992, Amsterdam, The Netherlands, Abstract Book, p. 26.
5. Inouye, K., Machida, Y., Sanna, T. and Nagai, T., Buoyant sustained release granules based on chitosan. Drug Des. Del., 4 (1989) 55-67.
6. Kamiya, E., Morimoto, K., Takeeda, T., Makamoto, Y. and Morisaka, K., Rectalabsorption of flurbiprofen, ketoprofen and indomethacin in polyacrilic acid aqueous gel preparation in rat. Int. J. Pharm., 17 (1983) 273-281.
7. Machida, Y. and Nagai, T., Chitin chitosan as pharmaceutical excipients, onwards better safety of drugs and pharmaceutical products, in Breimer, D.D. (Ed.). Proc. 4th Int. Congr. of Pharmaceutical Sciences of F.I.P., Munich, Germany, September 4-9, (1989, 1990) 211-221.
8. Reynolds, J.E.F. (Ed.), Martindale The Extra Pharmacopeia, Vol. 29, The Pharmaceutical Press, London, 1989, p. 25.
9. Miyazaki, S., Yamaguchi, H., Yokouchi, C., Takada, M. and Hou, W., Sustained release and intragastric-floating granules of indomethacin using chitosan in rabbits. Chem. Pharm. Bull., 36 (1988) 4033-4038.
10. Nagai, T., Sawayanagi, Y. and Nambu, N., Application of chitin and chitosan to pharmaceutical preparations. In Zikakis, J.P. (Ed.), Chitin. Chitosan and Releated Enzymes, Academic Press, San Diego. 1984, pp. 21-40.
11. Nakajima, T., Takashima, Y., Furuya, A., Ozawa, Y. and Kawashima, Y., Indomethacin sustained-release suppositories containing sugar ester. Chem. Pharm. Bull., 38 (1990) 1027-1031.
12. Nakajima, T., Takashima, Y., Lida, K., Mitsuta, H. and Koishi, M., Preparation and in vitro evaluation of sustained-release suppositories containing microencapsulated indomethacin. Chem. Pharm. Bull., 35 (1987) 1201-1206.
13. Nicholls, A.I. and Peck, C.C., LSNLR, General weighted least squares nonlinear regression program USUHS VERSION 1.0, User manual, Dep. Med. Pharmacol. Uniformed Services University of the Health Sciences, Bethesda, Maryland 20014, 1981.
14. Sawayanagi, Y., Nambu, N. and Nagai, T., Directly compressed tablets containing chitin and chitosan in addition to lactose or potato starch. Chem. Pharm. Bull., 30 (1982a) 2935-2940.
15. Sawayanagi, Y., Nambu, N. and Nagai, T., Enhancement of dissolution properties of griseofulvin from ground mixtures with chitin or chitosan. Chem. Pharm. Bull., 30 (1982b) 4464-4467.
16. Thomas, G. and Kantor, M.D., Ketoprofen: A review of its pharmacological and clinical properties. Pharmacotherapy, 6 (1986) 93-103.
17. Upton, R.A., Buskin, J.N., Guentert, T.W., Williams, R.L. and Reigelman, S., Convenient and sensitive high-performance liquid chromatography assay for ketoprofen, naproxen and other allied drugs in plasma or urine. J. Chromatogr., 190 (1980) 119-129.