c-kit Mutation in a population of patients with mastocytosis

International Archives of Allergy and Immunology

Volumn 113, Issue 1-3, 1997, Pages 184-186

  Nagata, Hiroshi ^a   Okada, Tadashi ^b   Worobec, Alexandra S ^c   Semere, Tekli ^c   Metcalfe, Dean D ^c  

^a CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AICHI MEDICAL UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

C kit; Mast cells; Mastocytosis; Stem cell factor

Indexed keywords

STEM CELL FACTOR;

CASE REPORT; CONFERENCE PAPER; GENE MUTATION; HUMAN; INFANT; MALE; MAST CELL; MASTOCYTOSIS; PRIORITY JOURNAL;

HUMANS; INFANT; MALE; MASTOCYTOSIS; MUTATION; PROTO-ONCOGENE PROTEINS C-KIT;

EID: 0030937554     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000237541     Document Type: Article

References (7)

1. Metcalfe, DD: Classification and diagnosis of mastocytosis: Current status, J Invest Dermatol 1991;96:2-4
2. Kirshenbaum AS, Goff JP, Kessler SW, Mican JM, Zsebo KM, Metcalfe DD: Effect of 11.-3 and stem cell factor on the appearance of human basophils and mast cells from CD34+ pluripotent progenitor cells, J Immunol 1992; 148:772- 777.
3. Rottem M, Okada T, Goff JP, Metcalfe DD: Mast cells cultured from the peripheral blood of normal donors and patients with mastocytosis originate from a CD34+/FceRI+ cell population, Blood 1994;84:2489-2496.
4. Tsujimura T, Furitsu T, Morimoto M, Isozaki K, Nomura S, Matsuzawa Y, Kitamura Y, Kanak-ura, Y: Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation, Blood 1994:83:2619-2626.
5. Butterfield JH, Weiler D, Dewald G, Gleich GJ: Establishment of an immature mast cell line from a patient with mast cell leukemia, Lcuk Res 1988:12:345-355.
6. Nagata H, Worobec AS, Oh CK, Chowdhury BA, Tannenbaum S, Suzuki Y, Metcalfe DD: Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder, Proc Natl Acad Sei USA 1995; 92:10560-10564.
7. Longlcy JB, Tyrrell L, Lu S-Z, Ma Y-S, Langley K, Ding T, Duffy T, Jacobs P, Tang LH, Modlin 1: Somatic c-kit activating mutation in urticaria pigmentosa and aggressive mastocytosis: Establishment of clonality in a human mast cell neoplasm, Nature Genet 1996:12:312-314