Paradoxical helium and sulfur hexafluoride single-breath washouts in short-term vs. sustained microgravity

Journal of Applied Physiology

Volumn 82, Issue 3, 1997, Pages 859-865

  Lauzon, Anne Marie ^a   Prisk, G Kim ^a,d   Elliott, Ann R ^a   Verbanck, Sylvia ^b   Paiva, Manuel ^c   West, John B ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

convection; diffusion; inhomogeneity; phase III slope

Indexed keywords

HELIUM; SULFUR HEXAFLUORIDE;

ADULT; ARTICLE; BREATH ANALYSIS; FEMALE; GAS DIFFUSION; HUMAN; HUMAN EXPERIMENT; LUNG BLOOD VOLUME; LUNG MECHANICS; MALE; MICROGRAVITY; NORMAL HUMAN; PRIORITY JOURNAL; SPACE FLIGHT; WEIGHTLESSNESS;

EID: 0030936721     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1997.82.3.859     Document Type: Article

References (21)

1. Buckey, J. C., F. A. Gaffney, L. D. Lane, B. D. Levine, D. E. Watenpaugh, and C. G. Blomqvist. Central venous pressure in space. New Engl. J. Med. 328: 1853-1854, 1993.
2. D'angelo, E., F. M. Robatto, E. Calderini, M. Tavola, D. Bondo, G. Torri, and J. Milic-Emili. Pulmonary and chest wall mechanics in anesthetized paralyzed humans. J. Appl. Physiol. 70: 2602-2610, 1991.
3. Engel, L. A., and P. T. Macklem. Gas mixing and distribution in the lung. In: Respiratory Physiology II, edited by J. G. Widdicombe. Baltimore, MD: University Park, 1977, vol. 14, p. 37-82. (Int. Rev. Physiol. Ser.)
4. Engel, L. A., M. Paiva, D. I. M. Siegler, and Y. Fukuchi. Dual tracer single breath studies of gas transport in the lung. Respir. Physiol. 36: 103-119, 1979.
5. Engel, L. A., L. D. H. Wood, G. Utz, and P. T. Macklem. Gas mixing during inspiration. J. Appl. Physiol. 35: 18-24, 1973.
6. Fowler, W. S. Lung function studies. III. Uneven pulmonary ventilation in normal subjects and in patients with pulmonary disease. J. Appl. Physiol. 2: 283-299, 1949.
7. Georg, J., N. A. Lassen, K. Mellemgaard, and A. Vinther. Diffusion in the gas phase of the lungs in normal and emphysematous subjects. Clin. Sci. Lond. 29: 525-532, 1965.
8. Guy, H. J. B., G. K. Prisk, A. R. Elliott, R. A. Deutschman III, and J. B. West. Inhomogeneity of pulmonary ventilation during sustained microgravity as determined by single-breath washouts. J. Appl. Physiol. 76: 1719-1729, 1994.
9. Guy, H. J. B., G. K. Prisk, A. R. Elliott, and J. B. West. Maximum expiratory flow-volume curves during short periods of microgravity. J. Appl. Physiol. 70: 2587-2596, 1991.
10. Haefeli-Bleuer, B., and E. R. Weibel. Morphometry of the human pulmonary acinus. Anat. Rec. 220: 401-414, 1988.
11. Lathers, C. M., J. B. Charles, K. F. Elton, T. A. Holt, C. Muckai, C. Bennett, and M. W. Bungo. Acute hemodynamic responses to weightlessness in humans. J. Clin. Pharmacol. 29: 615-627, 1989.
12. Michels, D. B., and J. B. West. Distribution of pulmonary ventilation and perfusion during short periods of weightlessness. J. Appl. Physiol. 45: 987-998, 1978.
13. Norsk, P., N. Foldager, F. Bonde-Petersen, B. Elmann-Larsen, and T. S. Johansen. Central venous pressure in humans during short periods of weightlessness. J. Appl. Physiol. 63: 2433-2437, 1987.
14. 2 alveolar plateau. Respir. Physiol. 44: 325-337, 1981.
15. Paiva, M., A. Van Muylem, P. Ravez, and J. C. Yernault. Preinspiratory lung volume dependence of the slope of the alveolar plateau. Respir. Physiol. 63: 327-338, 1986.
16. Prisk, G. K., H. J. B. Guy, A. R. Elliott, R. A. Deutschman III, and J. B. West. Pulmonary diffusing capacity, capillary blood volume, and cardiac output during sustained microgravity. J. Appl. Physiol. 75: 15-26, 1993.
17. Prisk, G. K., A.-M. Lauzon, S. Verbanck, A. R. Elliott, H. J. B. Guy, M. Paiva, and J. B. West. Anomalous behavior of helium and sulfur hexafluoride during single-breath tests in sustained microgravity. J. Appl. Physiol. 80: 1126-1132, 1996.
18. Van Muylem, A., M. Antoine, J.-C. Yernault, M. Paiva, and M. Estenne. Inert gas single-breath washout after heart-lung transplantation. Am. J. Crit. Care Med. 152: 947-952, 1995.
19. Van Muylem, A., P. DeVuyst, J.-C. Yernault, and M. Paiva. Inert gas single-breath washout and structural alteration of respiratory bronchioles. Am. Rev. Respir. Dis. 146: 1167-1172, 1992.
20. Verbanck, S., E. R. Weibel, and M. Paiva. Simulations of washout experiments in postmortem rat lung. J. Appl. Physiol. 75: 441-451, 1993.
21. 2 composition on nonlinearity of Fleisch pneumotachograph characteristics. J. Appl. Physiol. 56: 1423-1425, 1984.