Effect of antacid magaldrate oral suspension on in-vitro and in-vivo availability of indomethacin in dogs

Pharmaceutica Acta Helvetiae

Volumn 72, Issue 2, 1997, Pages 81-86

  Al Gohary, Omaimah M N ^a   Hosny, Ehab A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Antacids; Dogs; In vitro adsorption; In vivo availability; Indomethacin

Indexed keywords

ANTACID AGENT; INDOMETACIN; MAGALDRATE; PANCREATIN;

ADSORPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DESORPTION; DIFFERENTIAL SCANNING CALORIMETRY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INTESTINE FLUID; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ADSORPTION; ALUMINUM HYDROXIDE; ANIMALS; ANTACIDS; BIOLOGICAL AVAILABILITY; DOGS; DRUG INTERACTIONS; INDOMETHACIN; KINETICS; MAGNESIUM HYDROXIDE; MALE; SUSPENSIONS;

EID: 0030936585     PISSN: 00316865     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-6865(96)00059-3     Document Type: Article

References (21)

1. Abe, I., Kamaya H. and Ueda, I. (1990) Adsorption of local anesthetics on activated carbon: Freundlich adsorption isotherm. J. Pharm. Sci. 79, 354-358.
2. Al-Angary, A.A., El-Sayed, Y.M., Al-Meshal, M.A. and Lutfi, K.M. (1990) High-performance liquid chromatographic analysis of indomethacin in serum. J. Clin. Pharmacol. Ther. 15, 257-265.
3. Al-Gohary, O., Lyal, J. and Murray, J.B. (1988) Adsorption of antihypertensives by suspensoids. Part 2: The adsorption of acebutolol, metoprolol. nadolol, oxprenolol and timolol by attapulgite, charcoal, kaolin and magnesium trisilicate. Pharm. Acta. Helv. 63, 13-18.
4. Al-Gohary, O.M.N. (1991) An in-vitro study of the interaction between mebeverine hydrochloride and magnesium trisilicate powder. Int. J. Pharm. 67, 89-95.
5. Al-Gohary, O.M.N. (1995) Determinaton and characterization of the interaction between magaldrate antacid and some drugs: Part II. Acta Pharm. Helv. 70, 289-300.
6. Babhair, S.A. (1988) Decreased bioavailability of indenolol due to coadministration of some gastrointestinal drugs. Drug Dev. Ind. Pharm. 14, 867-872.
7. Busam, J. and Garbe, W.E. (1994) High dose omeprazole versus famotidine, pirenzepine and antacid in therapy of acute upper gastrointestinal hemorrhage in a retrospective comparison. Z. Gastroenterol. 32, 94-99.
8. Cataggio, P.M., Centurion, A., Alberti, H., Roldan, H. and Canepa, L. (1964) Indomethacin in rheumatoid arthiritis: Properties, side effects, Proc. Annu. Meeting American Rheumatism Association, June 18-19, San Francisco. Arthritis Rheum. 7, 300.
9. Galeazzi, R.L. (1977) The effect of an antacid on the bioavailability of indomethacin. Eur. J. Clin. Pharmacol. 12, 65-68.
10. Ganjian, F., Cutie, A.J. and Jochsberger, T. (1980) In-vitro adsorption studies of cimetidine. J. Pharm. Sci. 69, 352-353.
11. Gifford, R.H. (1973) Chemotherapy for rheumatoid arthritis. Rational Drug Ther. 7, 1-7.
12. Gugler, R., Brand, M. and Somogyi, A. (1981) Impaired cimetidine absorption due to antacids and metoclopramide. Eur. J. Clin. Pharmacol. 20, 225-228.
13. Hart, F.D. and Boardman, P.L. (1963) Indomethacin: A new non-steroid anti-inflammatory agent. Br. Med. J. 2, 965-970.
14. Kelly, M. (1964) Indomethacin, remarkable antirheumatic drug. Med. J. Aust. 51, 541-544.
15. Khalil, S.A. and Moustafa, M.A. (1973) The in-vitro adsorption of some drugs on antacids. Pharmazie 28H, 116-118.
16. Khalil, S.A., Naggar, V.F., Zaghloul, I.A. and Ismail, A.A. (1984) In-vitro anticoagulant-antacid interaction. J. Pharm. 19, 307-321.
17. Martindale (1982) The Extra Pharmacopeia, 28th Ed. The Pharmaceutical Press, London, 652 pp.
18. O'Brien, W.M. (1968) Indomethacin: A survey of clinical trials. Clin. Pharmacol. Ther. 9, 94-107.
19. Remon, J.P., Van Severen, R. and Braeckman, P. (1979) Differential thermal analysis and X-ray diffraction patterns of some drugs adsorbed on silicone dioxide. J. Pharm. Belg. 34, 77-82.
20. Remon, J.P., Belpaire, F., Van Severen, R. and Braeckman, P. (1983) Interaction of antacids with antiarrhythmics, V. Effect of aluminium hydroxide and magnesium oxide on the bioavailability of quinidine. procainamide and propranolol in dogs. Arzneim-Forsch. Drug Res. 33(I)(No. 1), 117-120.
21. Winter, C.A., Risley, E.A. and Nuss, G.W. (1963) Anti-inflammatory and antipyretic activities of indomethacin, 1-(p-chlorobenzoyl)5-methoxy-2-methylindole-3-acetic acid. J. Pharmacol. Exp. Ther. 141, 369-376.