Thromboembolic complications in a patient with heparin-induced thrombocytopenia (HIT) showing cross-reactivity to a low molecular weight heparin - Treatment with Org 10172 (Lomoparan)

Wiener Klinische Wochenschrift

Volumn 109, Issue 4, 1997, Pages 128-131

  Muhm, Manfred ^a,b   Claeys, Luc ^b   Huk, Igor ^b   Koppensteiner, Renate ^a   Kyrie, Paul A ^c   Minar, Erich ^a   Stümpften, Andreas ^a   Ehringer, Herbert ^a   Polterauer, Peter ^b  

^a Division of Angiology   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

heparin induced thrombocytopenia (HIT); low molecular weight heparin (LMWH); Org 10172

Indexed keywords

DALTEPARIN; DANAPAROID; HEPARIN; IMMUNOGLOBULIN; LOW MOLECULAR WEIGHT HEPARIN;

ADULT; ARTICLE; CASE REPORT; CROSS REACTION; DEEP VEIN THROMBOSIS; DRUG EFFICACY; HUMAN; MALE; THROMBOCYTOPENIA; THROMBOEMBOLISM;

ANTICOAGULANTS; CHONDROITIN SULFATES; CROSS REACTIONS; DERMATAN SULFATE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPARIN; HEPARIN, LOW-MOLECULAR-WEIGHT; HEPARITIN SULFATE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; PLATELET AGGREGATION; PULMONARY EMBOLISM; THROMBOCYTOPENIA; THROMBOPHLEBITIS;

EID: 0030936213     PISSN: 00435325     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Gatterer E, Stollberger C, Slany J, Stoberl C, Jaksch J (1988) Heparin bei tiefer Beinvenenthrombose - Effizienz und Sicherheit. Wien Klin Wochenschr 100: 601-605
2. Becker PS, Miller VT (1989) Heparin-induced thrombocytopenia. Stroke 10: 1449-1459
3. O'Reilly RA (1985) Anticoagulant, antithrombotic and thrombolytic drugs. In: Goodman and Gillman's the pharmacological basis of therapeutics, 7th edn. MacMillan, New York Toronto London, pp 1339-1359
4. Rhodes GR, Dixon RH, Silver D (1973) Heparin induced thrombocytopenia with thrombotic and hemorrhagic manifestations. Surg Gynecol Obstet 136: 409-416
5. Schafer AI, Handin RI, Kelton JG (1988) Platelets -thrombocytosis, von Willebrand's disease, drug-induced thrombocytopenia. In: Hematology - 1988, The Education Program of The American Society of Hematology. San Antonio, Texas, 3-6 December, pp 47-54
6. Cola C, Ansell J (1990) Heparin-induced thrombocytopenia and arterial thrombosis: alternative therapies. Am Heart J 119: 368-374
7. Jaffrey B, Welch GH, Cooke TG (1991) Fatal venous thrombosis after heparin therapy. Lancet 337: 561
8. Koneti Rao A, White GC, Sherman L, Colman R, Lan G, Ball AP (1989) Low incidence of thrombocytopenia with porcine mucosal heparin. A prospective multicenter study. Arch Intern Med 149: 1285-1288
9. Kyritsis AP, Williams EC, Schutta HS (1990) Cerebral venous thrombosis due to heparin-induced thrombocytopenia. Stroke 21: 1503-1505
10. Makhoul RG, Greenberg CS, McCann RL (1986) Heparin associated thrombocytopenia and thrombosis: a serious clinical problem and potential solution. J Vasc Surg 4: 522-528
11. Matsuo T, Yamada T. Chikahira Y, Kadowaki S (1989) Effect of aspirin on heparin-induced thrombocytopenia (HIT) in a patient requiring hemodialysis. Blut 59: 393-395
12. Greinacher A, Drost W, Michels I, Leitl J, Gottsmann M, Kohl HJ, Glaser M, et al (1992) Heparin-associated thrombocytopenia: successful therapy with the heparinoid Org 10172 in a patient showing cross-reaction to LMW heparins. Ann Hematol 64: 40-42
13. Warketin TE, Kelton JO (1991) Heparin-induced thrombocytopenia. Prog Hemost Thromb 10: 1-34
14. Binder K, Kyrle P, Schwarzinger I, Lechner K (1989) High-dose intravenous immunoglobulin therapy in (type II) heparin-induced thrombocytopenia with thromboembolic complication and disseminated intravascular coagulation. Blut 59: 411 (abstract)
15. Prull A, Nechwatal R, Riedel H, Maurer W (1992) Therapie des heparin-induzierten Thrombose-Thrombozytopenie-Syndroms mit Immunglobulinen. Dtsch Med Wochenschr 117: 1838-1812
16. Matsuo T, Chikahira Y, Yamada T, Nakao K, Ueshima S, Matsuo O (1988) Effect of synthetic thrombin inhibitor (MD805) as an alternative drug on heparin induced thrombocytopenia during hemodialysis. Thromb Res 52: 165-171
17. Matsuo T, Yamada T, Yamanashi T, Ryo R ( 1990) Anticoagulant therapy with MD805 of a hemodialysis patient with heparin-induced thrombocytopenia. Thromb Res 58: 663-666
18. Schiele F, Vuillemenot A, Kramarz P, Kieffer Y, Anguenot T, Bernard Y, Bassand JP (1995) Use of recombinant hirudin as antithrombotic treatment in patients with heparin-induced thrombocytopenia. Am J Hematol 50: 20-25
19. Chong BH, Ismail F, Cade J, Gallus AS, Gordon S, Chesterman CN (1989) Heparin-induced thrombocytopenia: studies with a new low molecular weight heparinoid, Org 10172. Blood 73: 1592-1596
20. Eichinger S, Kyrie PA, Brenner B, Wagner B, Kapiotis S, Lechner K, et al (1991) Thrombocytopenia associated with low-molecular-weight heparin. Lancet 337: 1425-1426
21. Ortel TL, Gockerman JP, Califf RM, McCann RL, O'Connor CM, Metzler DM, et al (1992) Parenteral anticoagulation with the heparinoid lomoparan (Org 10172) in patients with heparin-induced thrombocytopenia and thrombosis. Thromb Haemostas 67: 292-296
22. Rowlings PA, Mansberg R, Rozenberg MC, Evans S, Murray B (1991) The use of a low molecular weight heparinoid (Org 10172) for extracorporeal procedures in patients with heparin dependent thrombocytopenia and thrombosis. Aust NZ J Med 21: 52-54
23. van Besien K, Hoffman R, Golichowski A (1991) Pregnancy associated with lupus anticoagulant and heparin-induced thrombocytopenia: management with a low molecular weight heparinoid. Thromb Res 62: 23-29
24. Walls JT, Curtis JJ, Silver D, Boley TM (1990) Heparin-induced thrombocytopenia in patients who undergo open heart surgery. Surgery 108: 686-693
25. Magnani HN (1993) Heparin-induced thrombocytopenia (HIT): an overview of 230 patients treated with Orgaran (Org 10172). Thromb Haemost 70: 554-561
26. Greinacher A, Michels I, Kiefel V, Mueller-Eckhardt C (1992) Heparin-assoziierte Thrombozytopenie (HAT): erfolgreiche Therapie von Patienten nach prospektiver Auswahl eines kompatiblen Heparinoids mit dem Heparininduzierten Plättchenaktivierungs- (HTPA) Test. Beitr Infusionsther 30: 408-412
27. Manul P, Raynaud J, Favre JP, Jospe R, Decousus H, Auboyer C (1995) Thrombopenie a l'heparine sous hemodialyse en reanimation: utilisation d'un heparinoide de bas poids moleculaire, l'Org 10172 (Orgaran). Ann Fr Anesth Reanim 14: 29-32