Studies on new catechol containing cephalosporins. III. Synthesis and structure-activity relationships of cephalosporins having a pyridone moiety at the C-7 position

Journal of Antibiotics

Volumn 50, Issue 3, 1997, Pages 279-282

  Choi, Kyung Il ^a   Cha, Joo Hwan ^a   Pae, Ae Nim ^a   Cho, Yong Seo ^a   Koh, Hun Yeong ^a   Chang, Moon Ho ^a   Kang, Han Young ^b   Chung, Bong Young ^c  

^a Korea Institute of Science and Technology   (South Korea)

^b Chungbuk National University   (South Korea)

^c Korea University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL DERIVATIVE; CEFOTAXIME; CEFPIROME; CEPHALOSPORIN DERIVATIVE; PYRIDONE DERIVATIVE;

ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LD 50; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; NOTE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STRUCTURE ACTIVITY RELATION;

EID: 0030935439     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.50.279     Document Type: Note

References (7)

1. CHANG, M. H.; K. I. CHOI, J. H. CHA, A. N. PAE, Y. S. CHO, U. Y. KANG & H. Y. KOH: Studies on new catechol containing cephalosporins. I. Synthesis and structure-activity relationships of cephalosporins having a catechol moiety at the C-3 position. J. Antibiotics 48: 1371-1374, 1995
2. CHANG, M. H.; K. I. CHOI, J. H. CHA, A. N. PAE, Y. S. CHO, H. Y. KANG & H. Y. KOH: Studies on new catechol containing cephalosporins. II. Synthesis and structure-activity relationships of cephalosporins having a catechol moiety at the C-7 position. J. Antibiotics 48: 1375-1377, 1995
3. OGINO, H.; K. IWAMATSU, K. KATANO, S. NAKABAYASHI, T. YOSHIDA, T. TURUOKA, S. INOUYE & S. KONDO: New aminothiazolylglycylcephalosporins with a 1,5-dihydroxy-4-pyridone-2-carhonyl group. I. Synthesis and biological activity of cephalosporin derivatives leading to MT0703. J. Antibiotics 43: 174-188, 1990
4. ZAMA, Y.; N. ISHIYAMA, T. SAITA, T. NAITO, M. HIROSE, M. YOKOYAMA, T. ASANO, H. SENDA, K. SEKINE & S. SANAI: Cephalosporin compounds, processes for their preparation and antibacterial agents. Eur. Pat. 251299. July, 1, 1988
5. TAYLOR, E. C. & P. S. RAY: Pteridines. 54. A novel synthetic approach to C-6 carbon substituted pterins via intermolecular 1,3-dipolar cycloaddition reactions. J. Org. Chem. 56: 1812-1816, 1991
6. GIBSON, M. S. & R. W. BRADSHAW: The Gabriel synthesis of primary amines. Angew. Chem. Internat. Edit. 7: 919-930, 1968
7. LEITNER, F.; M. MISIEK, T. A. PURSIANO, R. E. BUCK, D. R. CHISHOLM, R. G. DEREGIS, Y. H. TSAI & K. E. PRICE: Laboratory evaluation of BL-S 786, a cephalosporin with broad-spectrum antibacterial activity. Antimicrob. Agents Chemother. 10: 426-435, 1976