Generation of a tumorigenic milk-borne mouse mammary tumor virus by recombination between endogenous and exogenous viruses

Journal of Virology

Volumn 71, Issue 5, 1997, Pages 3895-3903

  Golovkina, Tatyana V ^a   Piazzon, Isabel ^b   Nepomnaschy, Irene ^b   Buggiano, Valeria ^b   De Olano Vela, Marta ^a   Ross, Susan R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b INST DE INVEST HEMATOLOGICAS   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; FEMALE; LONG TERMINAL REPEAT; MAMMARY GLAND; MILK LEVEL; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STRAIN DIFFERENCE; VIRUS EXPRESSION; VIRUS RECOMBINATION;

EID: 0030935019     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.5.3895-3903.1997     Document Type: Article

References (55)

1. Acha-Orbea, H., A. N. Shakhov, L. Scarpellino, E. Kolb, V. Muller, A. Vessaz-Shaw, R. Fuchs, K. Blochlinger, P. Rullini, J. Billotte, M. Sarafidou, H. R. MacDonald, and H. Diggelmann. 1991. Clonal deletion of Vβ14-bearing T cells in mice transgenic for mammary tumor virus. Nature 350: 207-210.
2. Ando, Y., W. Wajjwalku, N. Niimi, K. Hiromatsu, T. Morishima, and Y. Yoshikai. 1995. Concomitant infection with exogenous mouse mammary tumor virus encoding I-E-dependent superantigen in I-E-negative mouse strain. J. Immunol. 154:6219-6226.
3. Beutner, U., W. N. Frankel, M. S. Cote, J. M. Coffin, and B. T. Huber. 1992. Mls-1 is encoded by the long terminal repeat open reading frame of the mouse mammary tumor provirus Mtv-7. Proc. Natl. Acad. Sci. USA 89:5432-5436.
4. Brandt-Carlson, C., J. S. Butel, and D. Wheeler. 1993. Phylogenetic and structural analysis of MMTV LTR ORF sequences of exogenous and endogenous origins. Virology 185:171-185.
5. Burdon, T. G., K. A. Maltland, A. J. Clark, B. Wallace, and C. Watson. 1994. Regulation of the sheep B-lactoglobulin gene by lactogenic hormones is mediated by a transcriptional factor that binds an interferon-γ activation site-related element. Mol. Endocrinol. 8:1528-1536.
6. Chervonsky, A., X. Jianchao, A. Barlow, M. Khery, R. Flavell, and C. Janeway. 1995. Direct physical interaction involving CD40 ligand on T cells and CD40 on B cells is required to propagate MMTV. Immunity 3:1-20.
7. Choi, Y., J. W. Kappler, and P. Marrack. 1991. A super antigen encoded in the open reading frame of the 3′ long terminal repeat of the mouse mammary tumor virus. Nature 350:203-207.
8. Choi, Y. C., D. H. Henrard, I. Lee, and S. R. Ross. 1987. The mouse mammary tumor virus long terminal repeat directs expression in epithelial and lymphoid cells of different tissues in transgenic mice. J. Virol. 61:3013-3019.
9. Coffin, J. M. 1990. Retroviridae and their replication, p. 1437-1500. In B. N. Fields and D. M. Knipe (ed.), Virology. Raven Press, New York.
10. Drohan, W., Y. A. Teramoto, D. Medina, and J. Schlom. 1981. Isolation and characterization of a new mouse mammary tumor virus from BALB/c mice. Virology 114:175-186.
11. Frankel, W. N., C. Rudy, J. M. Coffin, and B. T. Huber. 1991. Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice. Nature 349: 526-528.
12. Fritsch, E. F., and H. M. Temin. 1977. Inhibition of viral DNA synthesis in stationary chicken embryo fibroblasts infected with avian retroviruses. J. Virol. 24:461-469.
13. Golovkina, T., J. P. Dudley, A. B. Jaffe, and S. R. Ross. 1995. Mouse mammary tumor viruses with functional superantigen genes are selected during infection in vivo. Proc. Natl. Acad. Sci. USA 92:4828-4832.
14. Golovkina, T. V., A. Chervonsky, J. P. Dudley, and S. R. Ross. 1992. Transgenic mouse mammary tumor virus superantigen expression prevents viral infection. Cell 69:637-645.
15. Golovkina, T. V., A. Chervonsky, J. A. Prescott, C. A. Janeway, and S. R. Ross. 1994. The mouse mammary tumor virus envelope gene product is required for superantigen presentation to T cells. J. Exp. Med. 179:439-446.
16. Golovkina, T. V., A. Jaffe, and S. R. Ross. 1994. Coexpression of exogenous and endogenous mouse mammary tumor virus RNA in vivo results in viral recombination and broadens the virus host range. J. Virol. 68:5019-5026.
17. Golovkina, T. V., O. Prakash, and S. Ross. 1996. Endogenous mouse mammary tumor virus Mtv-17 is involved in Mtv-2-induced tumorigenesis in GR mice. Virology 218:14-22.
18. Golovkina, T. V., and S. Ross. Unpublished data.
19. Guyer, N. B., C. W. Sevens, P. Wong, C. A. Feghali, and T. M. Wright. 1995. IFN-gamma induces a p91/STAT1-alpha-related transcription factor with distinct and binding properties. J. Immunol. 155:3472-3480.
20. Held, W., A. N. Shakhov, G. Waanders, L. Scarpellino, R. Luethy, J.-P. Kraehenbuhl, H. R. MacDonald, and H. Acha-Orbea. 1992. An exogenous mouse mammary tumor virus with properties of Mls-1a (Mtv-7). J. Exp. Med. 175:1623-1633.
21. + T cells are required to stimulate B cells after infection with mouse mammary tumor virus. J. Exp. Med. 177:359-366.
22. Held, W., G. Waanders, A. N. Shakhov, L. Scarpellino, H. Acha-Orbea, and H. Robson-MacDonald. 1993. Superantigen-induced immune stimulation amplifies mouse mammary tumor virus infection and allows virus transmission. Cell 74:529-540.
23. Henrard, D., and S. R. Ross. 1988. Endogenous mouse mammary tumor virus is expressed in several organs in addition to the lactating mammary gland. J. Virol. 62:3046-3049.
24. Hodes, R. J., M. B. Novick, L. P. Palmer, and J. E. Knepper. 1993. Association of a Vβ-2-specific superantigen with a tumorigenic milk-borne mouse mammary tumor virus. J. Immunol. 150:1422-1428.
25. Ihle, J. N., and I. M. Kerr. 1995. JAKs and STATs in signaling by the cytokine receptor superfamily. Trends Genet. 11:69-74.
26. Jouvin-Marche, E., P. N. Marche, A. Six, C. Liebe-Gris, D. Voegtle, and P.-A. Cazenave. 1994. Identification of an endogenous mammary tumor virus involved in the clonal deletion of Vβ2 T cells. Eur. J. Immunol. 23:2758-2764.
27. Kang, J. J., T. Schwegel, and J. E. Knepper. 1993. Sequence similarity between the long terminal repeat coding regions of mammary-tumorigenic BALB/cV and adrenal-tumorigenic C3H-K strains of mouse mammary tumor virus. Virology 196:303-308.
28. Kozak, C., G. Peters, R. Pauley, V. Morris, R. Michalides, J. Dudley, M. Green, M. Davisson, O. Prakash, A. Vaidya, J. Hilgers, A. Verstraeten, N. Hynes, H. Diggelmann, D. Peterson, J. C. Cohen, C. Dickson, N. Sarkar, R. Nusse, H. Varmus, and R. Callahan. 1987. A standardized nomenclature for endogenous mouse mammary tumor viruses. J. Virol. 61:1651-1654.
29. Marrack, P., and J. Kappler. 1990. The staphylococcal enterotoxins and their relatives. Science 248:705-711.
30. Marrack, P., E. Kushnir, and J. Kappler. 1991. A maternally inherited superantigen encoded by mammary tumor virus. Nature 349:524-526.
31. Mohan, N., D. Mottershead, M. Subramanyam, U. Beutner, and B. Huber. 1993. Production and characterization of an Mls-1-specific monoclonal antibody. J. Exp. Med. 177:351-358.
32. Mok, E., T. V. Golovkina, and S. R. Ross. 1992. A mouse mammary tumor virus (MMTV) mammary gland enhancer confers tissue-specific, but not lactation-dependent expression in transgenic mice. J. Virol. 66:7529-7532.
33. Moore, D. H., C. A. Long, A. B. Vaidya, J. B. Sheffield, A. S. Dion, and E. Y. Lasfargues. 1979. Mammary tumor viruses. Adv. Cancer Res. 29:347-418.
34. Nandi, S., and C. M. McGrath. 1973. Mammary neoplasia in mice. Adv. Cancer Res. 17:353-414.
35. Nepomnaschy, I., A. Deroche, S. Torello, A. Goldman, V. Buggiano, C. D. Pasqualini, and I. Piazzon. 1990. Popliteal lymph node enlargement induced in syngeneic hosts by T cells from foster-nursed mice. Cell. Immunol. 128: 175.
36. Niimi, N., W. Wajjwalku, Y. Ando, N. Nakamura, M. Ueda, and Y. Yoshikai. 1995. A novel Vβ2-specific endogenous mouse mammary tumor virus which is capable of producing a milk-borne exogenous virus. J. Virol. 69:7269-7273.
37. Pandey, R., A. K. Ghosh, D. V. Kumar, B. A. Bachman, D. Shibata, and P. Roy-Burman. 1991. Recombination between feline leukemia virus subgroup B or C and endogenous env elements alters the in vitro biological activities of the viruses. J. Virol. 65:6495-6508.
38. Peters, G., and C. Dickson. 1987. On the mechanism of carcinogenesis by mouse mammary tumor virus, p. 307-319. In D. Medina, W. Kidwell, G. Heppner, and E. Anderson (ed.), Cellular and molecular biology of breast cancer. Plenum Publishing Corp., New York.
39. 37a. Piazzon, I., et al. Unpublished data.
40. bxa mothers. J. Immunol. 153:1553-1562.
41. Pullen, A. M., Y. Choi, E. Kushnir, J. Kappler, and P. Marrack. 1992. The open reading frames in the 3′ long terminal repeats of several mouse mammary tumor virus integrants encode Vβ3-specific superantigens. J. Exp. Med. 175:41-47.
42. 39a. Qin, W., et al. Unpublished data.
43. Rammensee, H.-G., R. Kroschewsky, and B. Frangoulis. 1989. Clonal anergy induced in mature Vβ6 T cells lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells. Nature (London) 339:541.
44. Ross, S. R. MMTV and the immune system. Annu. Rev. Pharm., in press.
45. Ross, S. R., and T. V. Golovkina. 1997. The role of endogenous MMTV loci in resistance to MMTV-induced mammary tumors. In K. Tomonari (ed.), Viral superantigens, in press. CRC Press, Inc., Boca Raton, Fla.
46. Ross, S. R., C.-L. Hsu, Y. Choi, E. Mok, and J. P. Dudley. 1990. Negative regulation in correct tissue-specific expression of mouse mammary tumor virus in transgenic mice. Mol. Cell. Biol. 10:5822-5829.
47. Schaefer, T. S., L. K. Sanders, and D. Nathans. 1995. Cooperative transcriptional activity of Jun and STAT3B, a short-form of STAT3. Proc. Natl. Acad. Sci. USA 92:9097-9101.
48. Schindler, C., and J. E. Darnell, Jr. 1995. Transcriptional responses to responses ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 64:621-651.
49. Shakhov, A. N., H. Wang, H. Acha-Orbea, R. J. Pauley, and W.-Z. Wei. 1993. A new infectious mammary tumor virus in the milk of mice implanted with C4 hyperplastic alveolar nodules. Eur. J. Immunol. 23:2765-2769.
50. Stoye, J. P., C. Moroni, and J. M. Coffin. 1991. Virological events leading to spontaneous AKR thymomas. J. Virol. 65:1273-1285.
51. Varmus, H. E., T. Padgett, S. Heasley, G. Simon, and J. M. Bishop. 1977. Cellular functions are required for the synthesis and integration of avian sarcoma virus-specific DNA. Cell 11:307-319.
52. Wakao, H., F. Goulilleux, and B. Groner. 1994. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J. 13:2182-2191.
53. Wellinger, R. J., M. Garcia, A. Vessaz, and H. Diggelmann. 1986. Exogenous mouse mammary tumor virus proviral DNA isolated from a kidney adenocarcinoma cell line contains alterations in the U3 region of the long terminal repeat. J. Virol. 60:1-11.
54. Yamamoto, K. 1985. Steroid receptor regulated transcription of specific genes and gene networks. Annu. Rev. Genet. 19:209-252.
55. Yazdanbakhsh, K., C. G. Park, G. M. Winslow, and Y. Choi. 1993. Direct evidence for the role of COOH terminus of mouse mammary tumor virus superantigen in determining T cell receptor Vβ specificity. J. Exp. Med. 178:737-741.