Randomised double blind study of hypotonic oral rehydration solution in diarrhoea

Archives of Disease in Childhood

Volumn 76, Issue 3, 1997, Pages 272-274

  Rautanen, Tarja ^a   Kurki, Seija ^a   Vesikari, Timo ^b  

^a JORVI HOSPITAL   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

diarrhoea; oral rehydration therapy; osmolarity; rotavirus

Indexed keywords

GLUCOSE; HYPOTONIC SOLUTION; ORAL REHYDRATION SOLUTION; SODIUM;

ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; HUMAN; MAJOR CLINICAL STUDY; ORAL DRUG ADMINISTRATION; ORAL REHYDRATION THERAPY; OSMOLARITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0030934239     PISSN: 00039888     EISSN: 14682044     Source Type: Journal    
DOI: 10.1136/adc.76.3.272     Document Type: Article

References (15)

1. Cunha Ferreira RMC. Optimising oral rehydration solution composition for the children of Europe: clinical trials. Acta Paediatr Scand 1989;364(suppl):40-50.
2. Report of an ESPGAN Working Group. Recommendations for composition of oral rehydration solutions for the children of Europe. J Pediatr Gastroenterol Nutr 1992;14: 113-5.
3. Hunt JB, Thillainayagum AV, Salim AFM, Carnaby S, Elliott EJ, Farthing MJG. Water and solute absorption from a new hypotonic oral rehydration solution: evaluation in human and animal perfusion models. Gut 1992;33:1652-9.
4. Sandhu BK, Christobal FL, Brueton MJ. Optimising oral rehydration solution composition in model systems:studies in normal mammalian small intestine. Acta Paediatr Scand 1989;364(suppl):17-22.
5. Farthing MJG. Disease-related animal models for optimising oral rehydration solution composition. Acta Paediatr Scand 1989;364(suppl):23-30.
6. Cunha Fereira RCM, Elliott EJ, Watson AJM, Brennan E, Walker-Smith JA, Farthing MJG. Dominant role for osmolality in the efficacy of glucose and glycine-containing oral rehydration solutions:studies in a rat model of secretory diarrhoea. Acta Paediatr 1992;81:46-50.
7. Rautanen T, El-Radhi S, Vesikah T. Clinical experience with a hypotonic oral rehydration solution in acute diarrhoea. Acta Paediatr 1993;82:52-4.
8. El-Mougi M, El-Akkad N, Hendawi A, et al. Is a low-osmolarity ORS solution more efficacious than standard WHO ORS solution? J Pediatr Gastroenterol Nutr 1994; 19:83-6.
9. Bhan MK, Chea Woo E, Fontaine O, Maulen-Radovan I, Pierce NF, Ribeiro H. Multicentre evaluation of reduced-osmolarity oral rehydration salts solution. Lancet 1995;345: 282-5.
10. Mahalanabis D, Faruque ASG, Hoque SS, Faruque SM. Hypotonic oral rehydration solution in acute diarrhoea: a controlled clinical trial. Acta Paediatr 1995;84:289-93.
11. Islam A, Molla AM, Ahmed MA, et al. Is rice based oral rehydration therapy effective in young infants? Arch Dis Child 1994;71:19-23.
12. El-Mougi M, Hegazi E, Galal O, et al. Controlled clinical trial on the efficacy of rice powder-based oral rehydration solution on the outcome of acute diarrhea in infants. J Pediatr Gastroenterol Nutr 1988;7:572-6.
13. Farthing MJG. Oral rehydration therapy. Pharmacol Ther 1994;64:477-92.
14. Thillainayagam AV, Carnaby S, Dias J, Clark MI, Farthing MJG. Evidence of a dominant role for low osmolality in the efficacy of cereal-based oral rehydration solutions: studies in a model of secretory diarrhoea. Gut 1993;34:920-5.
15. Gore SM, Fontaine O, Pierce NF. Impact of rice-based oral rehydration solutions on stool output and duration of diarrhoea: a meta-analysis of 13 clinical trials. BMJ 1992;304:287-91.