In vivo characterization of the colonic prokinetic effect of erythromycin in the rabbit

Pharmacology

Volumn 54, Issue 2, 1997, Pages 64-75

  Costa, Angela ^a   De Ponti, Fabrizio ^a   Gibelli, Graziano ^a   Crema, Francesca ^a   D’angelo, Luigi ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

Colonic motility; Erythromycin; Myoelectrical activity; Peristalsis; Prokinetic agents; Smooth muscle

Indexed keywords

ATROPINE; ERYTHROMYCIN; MUSCARINIC RECEPTOR; NIFEDIPINE; ONDANSETRON; SEROTONIN 3 RECEPTOR; TETRODOTOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASCENDING COLON; CALCIUM TRANSPORT; COLON MOTILITY; CONTROLLED STUDY; DESCENDING COLON; DOSE RESPONSE; DRUG EFFECT; EXTRACELLULAR CALCIUM; FECES; FEMALE; FORCE TRANSDUCER; INTESTINE MUSCLE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOTOR ACTIVITY; NONHUMAN; PRIORITY JOURNAL; RABBIT; REPRODUCIBILITY;

EID: 0030934065     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000139471     Document Type: Article

References (45)

1. Itoh Z, Nakaya M. Suzuki T, Arai H, Wakabayashi K: Erythromycin mimics exogenous motilin in gastrointestinal contractile activity in the dog. Am J Physiol 1984;247: G688-G694.
2. Zara GP. Thompson HH. Pilot MA. Ritchie HD: Effects of erythromycin on gastrointestinal tract motility. J Antimicrob Chemothcr 1985:16: 175-179.
3. l25l-motilin to duodenal muscle. Biochem Biophys Res Commun 1988:150:877-882.
4. Peeters T, Matthijs G. Depoortere I, Cachet T. Hoogmartens J. Vantrap-pen G: Erythromycin is a motilin receptor agonist. AmJ Physiol 1989; 257:G470-G474.
5. Tomomasa T, Kuroume T, Arai H. Wakabayashi K, Itoh Z: Erythromycin induces migrating motor complex in human gastrointestinal tract. DigDisSci 1986:31:157-161.
6. Qin XY. Scott M. Pilot MA. Thompson HH. Zara GP, Bonabello A: Canine colonic motility changes after erythromycin. Hepatogas-troenterology 1988:35:209.
7. Hasler W. Heldsinger A, Soudah H. Owyang C: Erythromycin promotes colonic transit in humans: Mediation via motilin receptors. Gastroenterology 1990;98:A358.
8. Bradette M. Poitras P. Boivin M: Effect of motilin and erythromycin on the motor activity of the human colon. J Gastrointest Motil 1993:5: 247-251.
9. Jameson JS. Rogers J. Misiewicz JJ, Raimundo AH. Henry MM: Oral or intravenous erythromycin has no effect on human distal colonic motility. Aliment Pharmacol Thcr 1992:6: 589-595.
10. Delvaux M. Louvel D. Fioramonti J, Staumont G, Bueno L. Frcxinos J: Effect of various doses of erythromycin on colonic myoclectrical activity in IBS patients. Neurogas-troenterol Motil 1994;6:205-212.
11. Sharma SS. Bhargava N. Mathur SC: Effect of oral erythromycin on colonic transit in patients with idiopathic constipation. A pilot study. Dig DisSci 1995:40:2446-2449.
12. Yanni G. Snapc WJ Jr.: Effect of erythromycin on colonic motility in patients with constipation. Gastroenterology 1992:103:1384.
13. Hasler WL, Heldsinger A. Owyang C: Erythromycin contracts rabbit colon myocites via occupation of motilin receptors. Am J Physiol 1992;262:G50-G55.
14. Depoortere I, Peeters TL, Vantrap-pen G: Motilin receptors of the rabbit colon. Peptides 1991; 12:89-94.
15. Itoh Z, Mizumoto A. lwanaga Y. Yoshida N. Torii N. Wakabayashi K: Involvement of 5-hydroxytrypta-mine 3 receptors in regulation of interdigestive gastric contractions of motilin in the dog. Gastroenterology 1991;100:901-908.
16. Inatomi N. Satoh H. Maki Y. Ha-shimoto N, Itoh Z. Omura S: An erythromycin derivative, EM-523, induces motilin-likc gastrointestinal motility in dogs. J Pharmacol Exp Ther 1989;251:707-712.
17. Ohtawa M, Mizumoto A, Hayashi N, Yanagida K. Itoh Z. Omura S: Mechanism of gastroprokinetic effect of EM-523, an erythromycin derivative, in dogs. Gastroenterology 1993:104:1320-1327.
18. Strunz U, Domschke W. Mitznegg P, Domschke S, Schubert E, Wtinsch E. Jaeger E. Demling L: Analysis of the motor effects of 13-norleucine motilin on the rabbit, guinea pig, rat and human alimentary tract in vitro. Gastroenterology 1975:68:1485-1491.
19. Satoh T. Inatomi N. Satoh H. Marui S. Itoh Z, Omura S: EM-523, an erythromycin derivative, and motilin show similar contractile activity in isolated rabbit intestine. J Pharmacol Exp Ther 1990;254:940-944.
20. Dc Ponti F. Costa A, Gibetli G. Frigo GM. Crema A: Characterization of the prokinetic effect of erythromycin on rabbit colonic motility. Pharm Res 1995:31:13.
21. Ruckebusch Y. Homicke H: Motility of the rabbit’s colon and cccotro-phy. Physiol Behav 1977:18:871-878.
22. Bologna SD. Hasler WL. Owyang C: Down-regulation of motilin receptors on rabbit colon myocytes by chronic oral erythromycin. J Pharmacol Exp Ther 1993:266:852-856.
23. Cosentino M. De Ponti F. D’Angelo L, Crema A: Motility of rabbit proximal colon. Relevance of cholinergic pathways and role of different muscarinic receptor subtypes. Dig Dis Sci 1992:37:1746-1753.
24. Matsumoto S. Yamasaki M. Kanno T. Nagayama T. Shimizu T: Effects of calcium channel and H-receptor blockers on the responses of slowly adapting pulmonary stretch receptors to histamine in vagotomized rabbits. Lung 1993; 171:1-13.
25. Bo P. Marchioni E. Soragna D, Mur-elli R, Savoldi F: Eegraphic and behavioural effects of ondansetron, a 5-HTj antagonist, in rabbits. Prog Neuropsychopharmacol Biol Psychiatry 1993; 17:801-823.
26. De Ponti F. Cosentino M. D'Angelo L, Frigo GM. Crema A: Prolonged monitoring of colonic spike activity by a computerized system: Application to the rabbit colon. Ital J Gastroenterol 1994;26:1-6.
27. Fioramonti J. Garcia-Villar R. Bueno L, Ruckebusch Y: Colonic myoelectrical activity and propulsion in the dog. Dig Dis Sci 1980:25: 641-646.
28. Tallarida RJ. Murray RB: Manual of Pharmacologic Calculations with Computer Programs, ed 2. New York. Springer, 1987.
29. Otterson MF, Sarna SK: Gastrointestinal motor effects of erythromycin. Am J Physiol 1990:259:355-363.
30. Minocha A, GalliganJJ: Erythromycin inhibits contractions of nerve-muscle preparations of the guinea pig small intestine. J Pharmacol Exp Ther 1991:257:1248-1252.
31. Lees GM. Percy WH: Antibiotic-associated colitis: An in vitro investigation of the effects of antibiotics on intestinal motility. Br J Pharmacol 1981;73:535-547.
32. Percy WH, Christensen J: Antibiotic depression of evoked and spontaneous responses of opossum distal colonic muscularis mucosae in vitro: A factor in antibiotic-associated colitis? Gastroenterology 1985:88: 964-970.
33. PliSka V: Models to explain dose-response relationships that exhibit a downturn phase. Trends Pharmacol Sci 1994;15:178-181.
34. Fox-Threlkeld JET. Manaka H. Ma-naka Y, Cipris S, Woskowska Z, Daniel EE: Mechanism of nonchol-inergic excitation of canine iieal circular muscle by motilin. Peptides 1991;12:1047-1050.
35. Marzio L. Grossi L. Martelli L. Fal-cucci M, Lapenna D: Migrating motor complex recorded spontaneously and induced by motilin and erythromycin in an ex vivo rabbit intestinal preparation. Peptides 1994:15: 1067-1077.
36. Marzio L. Giacobbe A. Facciorusso D. Tonti P, Andriulli A, Lapenna D: Erythromycin accelerates gastric and gallbladder emptying through a cholinergic mediated mechanism in humans. Gastroenterology 1993: 104:A547.
37. Miller P. Dickncr M. Trudel L. Mao YK. Daniel EE. St-Picrrc S, Poitras P: Two motilin receptor subtypes in the gastrointestinal tract of the rabbit. Gastroenterology 1995:108: A650.
38. Van Assche G, Depoortcre I. Peeters TL: Subcellular localization of the motilin receptor. Neurogastroente-rol Motil 1994;6:147.
39. Boivin M. Rivero Pinclo L. Plourde V, St-Pierrc S. Poitras P: Neural mediation of the motilin effect on the human antrum. Gastroenterology 1995; 108:A573.
40. Van Assche G. Thijs T. Depoortere I, Peelers TL: Excitatory effect of motilin on the isolated human colon. Gastroenterology 1995:108: A703.
41. 1’-motilin) on gastrointestinal motility in the rabbit. Br J Pharmacol 1994:111:288-294.
42. 2< channel blockers in inhibiting muscular and nerve activities in isolated colon. Br J Pharmacol 1991:102:735-741.
43. 2* dependence of motilidc-induced contractions in rabbit duodenal muscle strips in vitro. Naunyn Schmiedebergs Arch Pharmacol 1991:343:202-208.
44. Armstrong DN. Ballantyne GH. Modlin IM: Erythromycin stimulates ileal motility by activation of dihydropvridine-sensitive calcium channels. J Surg Res 1992:52:140-146.
45. Esser MJ, Mahoney JI. Robinson JC. Cowles VE, Condon RE: Effects of adrenergic agents on colonic motility. Surgery 1987;102:416-423.