Advances in the analysis of chromosome alterations in human lung carcinomas

Cancer Genetics and Cytogenetics

Volumn 95, Issue 1, 1997, Pages 20-32

  Testa, Joseph R ^a   Liu, Zemin ^a   Feder, Madelyn ^a   Bell, Daphne W ^a   Balsara, Binaifer ^a   Cheng, Jin Quan ^a   Taguchi, Takahiro ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME 13Q; CHROMOSOME 17P; CHROMOSOME 3P; CHROMOSOME 5Q; GENE DELETION; HUMAN; KARYOTYPING; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; PRIORITY JOURNAL; REVIEW;

EID: 0030934026     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-4608(96)00337-8     Document Type: Article

References (104)

1. Parker SL, Tong T, Bolden S, Wingo PA (1996): Cancer statistics. CA - Cancer J Clin 46:5-27.
2. Mitelman F (1991): Catalog of Chromosome Aberrations in Cancer. Alan R. Liss, New York.
3. Sozzi G, Bertoglio MG, Borrello MG, Giani S, Pilotti S, Pierotti M, Della Porta G (1987): Chromosomal abnormalities in a primary small cell lung cancer. Cancer Genet Cytogenet 27:45-50.
4. De Fusco PA, Frytak S, Dahl RJ, Weiland LH, Unni KK, Dewald GW (1989): Cytogenetic studies in 11 patients with small cell carcinoma of the lung, Mayo Clin Proc 64:168-176.
5. Miura I, Graziano SL, Cheng JQ, Doyle LA, Testa JR (1992): Chromosome alterations in human small cell lung cancer: Frequent involvement of 5q. Cancer Res 52:1322-1328.
6. Whang-Peng J, Kao-Shan CS, Lee EC, Bunn PA, Carney DN, Gazdar AF, Minna JD (1982): Specific chromosome defect associated with human small-cell lung cancer; deletion 3p(14-23). Science 215:181-182.
7. Morstyn G, Brown J, Novak U, Gardner J, Bishop J, Garson M (1987): Heterogeneous cytogenetic abnormalities in small cell lung cancer cell lines, Cancer Res 47:3322-3327,
8. Whang-Peng J, Bunn PA Jr, Kao-Shan CS, Lee EC, Carney DN, Gazdar A, Minna JD (1982): A nonrandom chromosomal abnormality, del 3p(14-23), in human small cell lung cancer (SCLC). Cancer Genet Cytogenet 6:119-134.
9. Wurster-Hill DH, Cannizzaro LA, Pettengill OS, Sorenson GD, Cate CC, Maurer LH (1984): Cytogenetics of small cell carcinoma of the lung. Cancer Genet Cytogenet 13:303-330.
10. Lee JS, Pathak S, Hopwood V, Tomasovic B, Mullins TD, Baker FL, Spitzer G, Neidhart JA (1987): Involvement of chromosome 7 in primary lung tumor and nonmalignant normal lung tissue. Cancer Res 47:6349-6352.
11. Viegas-Pequignot E, Flury-Herard A, De Cremoux H, Chlecq C, Bignon J, Dutrillaux B (1990): Recurrent chromosome aberrations in human lung squamous cell carcinomas. Cancer Genet Cytogenet 49:37-49.
12. Lukeis R, Irving L, Garson M, Hasthorpe S (1990): Cytogenetics of non-small cell lung cancer: Analysis of consistent non-random abnormalities. Genes Chromosom Cancer 2: 116-124.
13. Miura I, Siegfried JM, Resau J, Keller SM, Zhou JY, Testa JR (1990): Chromosome alterations in 21 non-small cell lung carcinomas, Genes Chromosom Cancer 2:328-338.
14. Flury-Herard A, Viegas-Pequignot E, De Cremoux H, Chlecq C, Bignon J, Dutrillaux B (1992): Cytogenetic study of five cases of lung adenosquamous carcinomas. Cancer Genet Cytogenet 59:1-8.
15. Liang JC, Kurzrock R, Gutterman JU, Gallick GE (1986): Trisomy 12 correlates with elevated expression of p21 ras in a human adenosquamous carcinoma of the lung. Cancer Genet Cytogenet 23:183-188.
16. Jin Y, Mandahl N, Heim S, Schuller H, Mitelman F (1988): Isochromosomes i(8q) or i(9q) in three adenocarcinomas of the lung. Cancer Genet Cytogenet 33:11-17.
17. Ronne M, Elberg JJ, Shibasaki Y, Andersen K (1989): A case of squamous cell lung carcinoma with tetrasomy 7 and chromosome 1 C-band polymorphism. Anticancer Res 9:1101-1103.
18. Pejovic T, Heim S, Orndal C, Jin YS, Mandahl N, Willen H, Mitelman F (1990): Simple numerical chromosome aberrations in well-differentiated malignant epithelial tumors, Cancer Genet Cytogenet 49:95-101.
19. Johansson M, Jin Y, Heim S, Mandahl N, Hambraeus G, Johansson L, Mitelman F (1992): Pseudodiploid karyotypes in adenosquamous carcinomas of the lung. Cancer Genet Cytogenet 63:95-96.
20. Drouin V, Viguie F, Debesse B (1993): Near-haploid karyotype in a squamous cell lung carcinoma. Genes Chromosom Cancer 7:209-212.
21. Zech L, Bergh J, Nilsson K (1985): Karyotypic characterization of established cell lines and short-term cultures of human lung cancers. Cancer Genet Cytogenet 15:335-347.
22. Fan YS, Li P (1987): Cytogenetic studies of four human lung adenocarcinoma cell lines. Cancer Genet Cytogenet 26:317-325.
23. Rey JA, Bello MJ, de Campos JM, Kusak ME, Moreno S, Benitez J (1987): Deletion 3p in two lung adenocarcinomas metastatic to the brain. Cancer Genet Cytogenet 25:355-360.
24. Bello MJ, Moreno S, Rey JA (1989): Involvement of chromosomes 1,3, and i(8q) in lung adenocarcinoma. Cancer Genet Cytogenet 38:133-135.
25. Cagle PT, Taylor LD, Schwartz MR, Ramzy I, Elder FF (1989): Cytogenetic abnormalities common to adenocarcinoma metastatic to the pleura. Cancer Genet Cytogenet 39: 219-225.
26. Kadowaki MH, Ferguson MK (1990): The role of chromosome 3 deletions in lung cancer. Lung Cancer 6:165-170.
27. Erdel M, Peter W, Spiess E, Trefz G, Ebert W (1990): Karyotypic characterization of established cell lines derived from a squamous cell carcinoma and an adenocarcinoma of human lung cancers. Cancer Genet Cytogenet 49:185-198.
28. Whang-Peng J, Knutsen T, Gazdar A, Steinberg SM, Oie H, Linnoila I, Mulshine J, Nau M, Minna JD (1991): Nonrandom structural and numerical chromosome changes in nonsmall-cell lung cancer. Genes Chromosom Cancer 3:168-188.
29. Law E, Gilvarry U, Lynch V, Gregory B, Grant G, Clynes M (1992): Cytogenetic comparison of two poorly differentiated human lung squamous cell carcinoma lines. Cancer Genet Cytogenet 59:111-118.
30. Lukeis R, Ball D, Irving L, Garson OM, Hasthorpe S (1993): Chromosome abnormalities in non-small cell lung cancer pleural effusions: Cytogenetic indicators of disease subgroups. Genes Chromosom Cancer 8:262-269.
31. Testa JR, Siegfried JM, Liu Z, Hunt JD, Feder MM, Litwin S. Zhou JY, Taguchi T, Keller SM (1994): Cytogenetic analysis of 63 non-small cell lung carcinomas: Recurrent chromosome alterations amid frequent and widespread genomic upheaval. Genes Chromosom Cancer 11:178-194.
32. Johansson M, Dietrich C, Mandahl N, Hambraeus G, Johansson L, Clausen PP, Mitelman F, Heim S (1994): Karyotypic characterization of bronchial large cell carcinomas. Inter J Cancer 57:463-467.
33. . Johansson M, Karauzum SB, Dietrich C, Mandahl N, Hambraeus G, Johansson L, Clausen PP, Mitelman F, Heim S (1994): Karyotypic abnormalities in adenocarcinomas of the lung. Inter J Oncol 5:17-26.
34. Johansson M, Jin Y, Mandahl N, Hambraeus G, Johansson L. Mitelman F, Heim S (1995): Cytogenetic analysis of shortterm cultured squamous cell carcinomas of the lung. Cancer Genet Cytogenet 81:46-55.
35. Testa JR and Siegfried JM (1992): Chromosome abnormalities in human non-small cell lung cancer. Cancer Res 52: 2702s-2706s.
36. Kallioniemi A. Kallioniemi OP. Sudar D, Rutovitz D. Gray JW, Waldman F, Pinkel D (1992): Comparative genomic hybridization for molecular Cytogenetic analysis of solid tumors. Science 258:818-821.
37. Boring CC. Squires TS, Tong T (1992): Cancer statistics. 1992. CA-Cancer J Clin 42:19-38.
38. Siegfried JM (1987): Detection of human lung epithelial cell growth factors produced by a lung carcinoma cell line: Use in culture of primary solid lung tumors. Cancer Res 47: 2903-2910.
39. Siegfried JM, Resau J. Miura I. Testa JR (1991): Primary culture of solid lung tumors for chromosomal analysis. In: Advanced Techniques in Chromosome Research. Adolph KW, ed., Marcel Dekker, New York, pp. 411-425.
40. Siegfried JM, Hunt JD, Zhou JY, Keller SM, Testa JR (1993): Cytogenetic abnormalities in non-small cell lung carcinoma: Similarity of findings in conventional and feeder cell layer cultures. Genes Chromosom Cancer 6:30-38.
41. Siegfried JM, Ellison DJ, Resau JH, Miura I, Testa JR (1991): Correlation of modal chromosome number of cultured nonsmall cell lung carcinomas with DNA index of solid tumor tissue. Cancer Res 51:3267-3673.
42. Lukeis RE (1994): Characterisation and Significance of Chromosome Abnormalities in Non-Small Cell Lung Cancer. Ph.D. thesis. University of Melbourne.
43. du Manoir S, Speicher MR, Joos S, Schrock E, Popp S, Dohner H, Kovacs G, Robert-Nicoud M, Lichter P, Cremer T (1993): Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization. Hum Genet 90:590-610.
44. Ried T, Petersen I, Holtgreve-Grez H, Speicher MR, Schrock E, du Manoir S, Cremer T (1994): Mapping of multiple DNA gains and losses in primary small cell lung carcinomas by comparative genomic hybridization. Cancer Res 34:1801-1806.
45. Speicher MR, Gwyn Ballard S, Ward DC (1996): Karyotyping human chromosomes by combinatorial multi-fluor FISH. Nature Genet 12:368-375.
46. Schrock E, du Manoir S, Veldman T, Schoell B, Wienberg J, Ferguson-Smith MA, Ning Y, Ledbetter DH, Bar-Am I, Soenksen D, Garini Y, Ried T (1996): Multicolor spectral karyotyping of human chromosomes. Science 273:494-497.
47. Testa JR, Graziano SL (1993): Molecular implications of recurrent cytogenetic alterations in human small cell lung cancer. Cancer Detect Prevent 17:267-277.
48. de Leij L, Postmus PE, Buys CH, Elema JD, Ramaekers F, Poppema S, Brouwer M, van der Veen AY, Mesander G, The TH (1985); Characterization of three new variant type cell linos derived from small cell carcinoma of the lung. Cancer Res 45:6024-6033.
49. Falor WH, Ward-Skinner R, Wegryn S (1985): A 3p deletion in small cell lung carcinoma. Cancer Genet Cytogenet 16: 175-177.
50. Bepler G, Jaques G, Koehler A, Gropp C, Havemann K (1985): Markers and characteristics of human SCLC cell lines. Neuroendocrine markers, classical tumor markers, and chromosomal characteristics of permanent human small cell lung cancer cell lines. J Cancer Res Clin Oncol 113:253-259.
51. Graziano SL, Cowan BY, Carney DN, Bryke CR, Mitter NS, Johnson BE, Mark GE, Planas AT, Catino JJ, Comis RL, Poiesz BJ (1987): Small cell lung cancer cell line derived from a primary tumor with a characteristic deletion of 3p. Cancer Res 47:2148-2155.
52. Graziano SL, Pfeifer AM, Testa JR, Mark GE, Johnson BE, Hallinan EJ, Pettengill OS, Sorenson GD, Tatum AH, Brauch H, Zbar B, Flejter WL, Ehrlich GD, Poiesz BJ (1991): Involvement of the RAF1 locus, at band 3p25, in the 3p deletion of small-cell lung cancer. Genes Chromosom Cancer 3:283-293.
53. Brauch H, Johnson B, Hovis J, Yano T, Gazdar A, Pettengill OS, Graziano S, Sorenson GD, Poiesz BJ, Minna J, Linehan M, Zbar B (1987): Molecular analysis of the short arm of chromosome 3 in small-cell and non-small-cell carcinoma of the lung. N Engl J Med 317:1109-1113.
54. Naylor SL, Johnson BE, Minna JD, Sakaguchi AY (1987): Loss of heterozygosity of chromosome 3p markers in smallcell lung cancer. Nature 329:451-454.
55. Cavenee WK, Dryja TP, Phillips RA, Benedict WF, Godbout R, Gallie BL, Murphree AL, Strong LC, White RL (1983): Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature 305:779-784.
56. Kok K, Osinga J, Carritt B, Davis MB, van der Hout AH, van der Veen AY, Landsvater RM, de Leij LF, Berendsen HH, Postmus PE, Poppema S, Buys CHCM (1987): Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer. Nature 330:578-581.
57. Ibson JM, Waters JJ, Twentyman PR, Bleehen NM, Rabbitts PH (1987): Oncogene amplification and chromosomal abnormalities in small cell lung cancer. J Cell Biochem 33:267-288.
58. Sithanandam G, Dean M, Brennscheidt U, Beck T, Gazdar A, Minna JD, Brauch H, Zbar B, Rapp UR (1989): Loss of heterozygosity at the c-raf locus in small cell lung carcinoma. Oncogene 4:451-455.
59. Brauch H, Tory K, Kotler F, Gazdar AF, Pettengill OS, Johnson B, Graziano S, Winton T, Buys CH, Sorenson GD, Poiesz BJ, Minna JD, Zbar B (1990): Molecular mapping of deletion sites in the short arm of chromosome 3 in human lung cancer. Genes Chromosom Cancer 1:240-246.
60. Rabbitts P, Bergh J, Douglas J, Collins F, Waters J (1990): A submicroscopic homozygous deletion at the D3S3 locus in a cell line isolated from a small cell lung carcinoma. Genes Chromosom Cancer 2:231-238.
61. Latif F, Tory K, Modi WS, Graziano SL, Gamble G, Douglas J, Heppell-Parton AC, Rabbitts PH, Zbar B, Lerman MI (1992): Molecular characterization of a large homozygous deletion in the small cell lung cancer cell line U2020: A strategy for cloning the putative tumor suppressor gene. Genes Chromosom Cancer 5:119-127.
62. Todd S, Roche J, Hahner L, Bolin R, Drabkin HA, Gemmill RM (1995): YAC contigs covering an 8-megabase region of 3p deleted in the small-cell lung cancer cell line U2020. Genomics 25:19-28.
63. Roche J, Boldog F, Robinson M, Robinson L, Varella-Garcia M, Swanton M, Waggoner B, Fishel R, Franklin W, Gemmil R, Drabkin H (1996): Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin. Oncogene 12:1289-1297.
64. Sekido Y, Bader S, Latif F, Chen J-Y, Duh F-M, Wei M-H, Albanesi JP, Lee C-C, Lerman MI, Minna JD (1996): Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns. Proc Natl Acad Sci USA 93:4120-4125.
65. Wei MH, Latif F, Bader S, Kashuba V, Chen JY, Duh FM, Sekido Y, Lee CC, Geil L, Kuzmin I, Zabarovsky E, Klein G, Zbar B, Minna JD, Lerman MI (1996): Construction of a 600kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: Progress toward the isolation of a lung cancer TSG. Cancer Res 56:1487-1492.
66. Yamakawa K, Takahashi T, Horio Y, Murata Y, Takahashi E, Hibi K, Yokoyama S, Ueda R, Takahashi T, Nakamura Y (1993): Frequent homozygous delations in lung cancer cell lines detected by a DNA marker located at 3p21.3-p22. Oncogene 8:327-330.
67. Murata Y, Tamari M, Takahashi T, Horio Y, Hibi K, Yokoyama S, Inazawa J, Yamakawa K, Ogawa A, Takahashi T, Nakamura Y (1994): Characterization of an 800 kb region at 3p22-p21.3 that was homozygously deleted in a lung cancer cell line. Hum Molec Genet 3:1341-1344.
68. Sozzi G, Veronese ML, Negrini M, Baffa R, Cotticelli MG, Inoue H, Tornielli S, Pilotti S, De Gregorio L, Pastorino U, Pierotti MA, Ohta M, Huebner K, Croce CM (1996): The FHITgene 3p14.2 is abnormal in lung cancer. Cell 85:17-26.
69. Sekido Y, Bader S, Latif F, Gnarra JR, Gazdar AF, Linehan WM, Zbar B, Lerman MI, Minna JD (1994): Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines. Oncogene 9:1599-1604.
70. Cannizzaro LA, Skolnik EY, Margolis B, Croce CM, Schlesinger J, Huebner K (1991): The human gone encoding phosphatidylinositol-3 kinase associated p85 alpha is at chromosome region 5q12-13. Cancer Res 51:3818-3820.
71. Escobedo JA, Navankasattusas S, Kavanaugh WM, Milfay D, Fried VA, Williams LT (1991): cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of P13-kinase to the PDGF beta-receptor. Cell 65:75-82.
72. Bishop DT, Westbrook C (1990): Report of the committee on the genetic constitution of chromosome 5. Cytogenet Cell Genet 55:111-117.
73. Nishisho I, Nakamura Y, Miyoshi Y, Miki Y, Ando H, Horii A, Koyama K, Utsunomiya J, Baba S, Hedge P (1991): Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 253:665-669.
74. D'Amico D, Carbone DP, Johnson BE, Meltzer SJ, Minna JD (1992): Polymorphic sites within the MCC and APC loci reveal very frequent loss of heterozygosity in human small cell lung cancer. Cancer Res 52:1996-1999.
75. Wieland I, Bohm M, Bogatz S (1992): Isolation of DNA sequences deleted in lung cancer by genomic difference cloning. Proc Natl Acad Sci USA 89:9705-9709.
76. Motegi T, Komatsu M, Nakazato Y, Ohuchi M, Minoda K (1982): Retinoblastoma in a boy with a de novo mutation of a 13/18 translocation: The assumption that the retinoblastoma locus is at 13q14.1, particularly at the distal portion of it. Hum Genet 60:193-195.
77. Friend SH, Bernards R, Rogelj S, Weinberg RA, Rapaport JM, Albert DM, Dryja TP (1986): A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323:643-646.
78. Harbour JW, Lai SL, Whang-Peng J, Gazdar AF, Minna JD, Kaye FJ (1988): Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science 241:353-357.
79. Yokota J, Wada M, Shimosato Y, Terada M, Sugimura T (1987): Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung. Proc Natl Acad Sci USA 84:9252-9256.
80. Takahashi T, Nau MM, Chiba I, Birrer MJ, Rosenberg RK, Vinocour M, Levitt M, Pass H, Gazdar AF, Minna JD (1989): p53: A frequent target for genetic abnormalities in lung cancer. Science 246:491-494.
81. Nigro JM, Baker SJ, Preisinger AC, Jessup JM, Hostetter R, Cleary K, Bigner SH, Davidson N, Baylin S, Devilee P, Glover T, Collins FS, Weston A, Modali R, Harris CC, Vogelstein B (1989): Mutations in the p53 gene occur in diverse human tumour types. Nature 342:705-708.
82. Kaufman RJ, Brown PC, Schimke RT (1979): Amplified dihydrofolate reductase genes in unstably methotrexate resistant cells are associated with double minute chromosomes. Proc Natl Acad Sci USA 76:5669-5673.
83. Lin CC, Alitalo K, Schwab M, George D, Varmus HE, Bishop JM (1985): Evolution of karyotypic abnormalities and C-MYC oncogene amplification in human colonic carcinoma cell lines. Chromosoma 92:11-15.
84. Little CD, Nau MM, Carney DN, Gazdar AF, Minna JD (1983): Amplification and expression of the c-myc oncogene in human lung cancer cell lines. Nature 306:194-196.
85. Nau MM, Brooks BJ, Battey J, Sausville E, Gazdar AF, Kirsch IR, McBride OW, Bertness V, Hollis GF, Minna JD (1985): L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer. Nature 318:69-73.
86. Nau MM, Brooks BJ Jr., Carney DN, Gazdar AF, Battey JF, Sausville EA, Minna JD (1986): Human small-cell lung cancers show amplification and expression of the N-myc gene. Proc Natl Acad Sci USA 83:1092-1096.
87. Wong AJ, Ruppert JM, Eggleston J, Hamilton SR, Baylin SB, Vogelstein B (1986): Gene amplification of c-myc and N-myc in small cell carcinoma of the lung. Science 233:461-464.
88. Brennan J, O'Connor T, Makuch RW, Simmons AM, Russell E, Linnoila RI, Phelps RM, Gazdar AF, Ihde DC, Johnson BE (1991); myc family DNA amplification in 107 tumors and tumor cell lines from patients with small cell lung cancer treated with different combination chemotherapy regimens. Cancer Res 51:1708-1712.
89. Elfving P, Lundgren R, Cigudosa JC, Heim S, Mandahl N, Mitelman F (1992): Trisomy 7 in non neoplastic kidney tissue cultured with and without epidermal growth factor [letter]. Cancer Genet Cytogenet 64:99-100.
90. Elfving P, Cigudosa JC, Lundgren R, Limon J Mandahl N, Kristoffersson U, Heim S, Mitelman F (1990): Trisomy 7, trisomy 10, and loss of the Y chromosome in short-term cultures of normal kidney tissue. Cytogenet Cell Genet 53:123-125.
91. Dal Cin P, Aly MS, Delabie J, Ceuppens JL, Van Gool S, Van Damme B, Baert L, Van Poppel H, van den Berghe H (1992): Trisomy 7 and trisomy 10 characterize subpopulations of tumor-infiltrating lymphocytes in kidney tumors and in the surrounding kidney tissue. Proc Natl Acad Sci USA 89: 9744-9748.
92. Weston A, Willey JC, Modali R, Sugimura H, McDowell EM, Resau J, Light B, Haugen A, Mann DL, Trump BF, Harris CC (1989): Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, largecell carcinoma, and adenocarcinoma of the human lung. Proc Natl Acad Sci USA 86:5099-5103.
93. Rabbitts P, Douglas J, Daly M, Sundaresan V, Fox B, Haselton P, Wells F, Albertson D, Waters J, Bergh J (1989): Frequency and extent of allelic loss in the short arm of chromosome 3 in nonsmall-cell lung cancer. Genes Chromosom Cancer 1:95-105.
94. Viallet J, Minna JD (1990): Dominant oncogenes and tumor suppressor genes in the pathogenesis of lung cancer. Am J Respir Cell Molec Biol 2:225-232.
95. Olopade OI, Buchhagen DL, Malik K, Sherman J, Nobori T, Bader S, Nau MM, Gazdar AF, Minna JD, Diaz MO (1993): Homozygous loss of the Interferon genes defines the critical region on 9p that is deleted in lung cancers. Cancer Res 53:2410-2415.
96. de Vos S, Miller CW, Takeuchi S, Gombart AF, Cho SK, Koeffler HP (1995): Alterations of CDKN2 (p16) in non-small cell lung cancer. Genes Chromosom Cancer 14:164-170.
97. Washimi O, Nagatake M, Osada H, Ueda R, Koshikawa T, Seki T, Takahashi T, Takahashi T (1995): In vivo occurrence of p16 (MTS1) and p15 (MTS2) alterations preferentially in non-small cell lung cancers. Cancer Res 5:514-517.
98. Yokota J, Wada M, Yoshida T, Noguchi M, Terasaki T, Shimosato Y, Sugimura T, Terada M (1988): Heterogeneity of lung cancer cells with respect to the amplification and rearrangement of myc family oncogenes. Oncogene 2:607-611.
99. Gemma A, Nakajima T, Shiraishi M, Noguchi M, Gotoh M, Sekiya T, Niitani H, Shimosato Y (1988): myc family gene abnormality in lung cancers and its relation to xenotransplantability. Cancer Res 48:6025-6028.
100. Miyaki M, Sato C, Matsui T, Koike M, Mori T, Kosaki G, Takai S, Tonomura A, Tsuchida N (1985): Amplification and enhanced expression of cellular oncogens c-Ki-ras-2 in a human epidermoid carcinoma of the lung. Jpn J Cancer Res 76:260-265.
101. Tsuchiya E, Nakamura Y, Weng SY, Nakagawa K, Tsuchiya S, Sugano H, Kitagawa T (1992): Allelotype of non-small cell lung carcinoma-Comparison between loss of heterozygosity in squamous cell carcinoma and adenocarcinoma. Cancer Res 52:2478-2481.
102. Taguchi T, Zhou J-Y, Feder M, Litwin S, Klein-Szanto AJP, Testa JR (1996): Detection of aneuploidy in interphase nuclei from non-small cell lung carcinomas by fluorescence in situ hybridization using chromosome-specific repetitive DNA probes. Cancer Genet Cytogenet 89:120-125.
103. Levin NA, Brzoska P, Gupta N, Minna JD, Gray JW, Christman MF (1994): Identification of frequent novel genetic alterations in small cell lung carcinoma. Cancer Res 54: 5086-5091.
104. Levin NA, Brzoska PM, Warnock ML, Gray JW, Christman MF (1995): Identification of novel regions of altered DNA copy number in small cell lung tumors. Genes Chromosom Cancer 13:175-185.