Effect of the anticholinergic drug with calcium antagonistic activity, (±)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate, on lower urinary tract function in decerebrated dogs

Arzneimittel-Forschung/Drug Research

Volumn 47, Issue 2, 1997, Pages 182-189

  Kimura, Yutaka ^a   Fukui, Hisashi ^a   Hamada, Kozo ^a   Ogasawara, Takashi ^a   Yamazaki, Chiemi ^a   Ukai, Yojiro ^a   Yoshikuni, Yoshiaki ^a   Kimura, Kiyoshi ^a  

^a NIPPON SHINYAKU CO LTD   (Japan)

Author keywords

( ) 4 diethylamino 1,1 dimethylbut 2 yn 1 yl 2 cyclohexyl 2 hydroxy 2 phenylacetate monohydrochloride monohydrate; anticholinergic drugs, with calcium antagonistic activity; CAS 129927 33 4; lower urinary tract, dog; NS 21, metabolite; RCC 36, effect on urodynamics

Indexed keywords

2 CYCLOHEXYL 2 HYDROXY 2 PHENYLACETIC ACID 4 ETHYLAMINO 1,1 DIMETHYL 2 BUTYNYL ESTER; ATROPINE; CHOLINERGIC RECEPTOR BLOCKING AGENT; DRUG METABOLITE; OXYBUTYNIN; PROPIVERINE; TEMIVERINE; TERODILINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER CAPACITY; BLADDER DYSFUNCTION; BLADDER FUNCTION; BLADDER PRESSURE; CONTROLLED STUDY; CYSTOMETRY; DECEREBRATION; DOG; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MICTURITION; NONHUMAN; POLLAKISURIA; RESIDUAL URINE; URINARY TRACT FUNCTION; URINE INCONTINENCE; URODYNAMICS;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CHOLINERGIC ANTAGONISTS; DECEREBRATE STATE; DOGS; ELECTROMYOGRAPHY; PHENYLACETATES; URINARY BLADDER; URINARY TRACT; URINATION; URODYNAMICS;

EID: 0030933601     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Husted, S., Andersson, K-E., Sommer, L. et al., Acta Pharmacol. Toxicol. 46 (Suppl. I), 20 (1980)
2. Aida, Y., Kaneko, Y., Kasama, T., Folia Pharmacol. Jpn. 87, 629 (1986)
3. Haruno, A., Yamasaki, Y., Miyoshi, K. et al., Folia Pharmacol. Jpn. 94, 145 (1989)
4. Nishizawa, O., Fukuda, T., Matsuzaki, A. et al., J. Urol. 134, 1259 (1985)
5. Nishizawa, O., Sugaya, K., Noto, H. et al., J. Urol. 140, 872 (1988)
6. Tsuchiya, K., Nagai, M., Nakajima, M. et al., J. Auton. Nerv. Syst. 21, 63 (1984)
7. Mayuzumi, K., Watanabe, K., Tamaru, K. et al., Folia Pharmacol. Jpn. 87, 557 (1986)
8. Abe, M., Ono, Y., Yamazaki, Y. et al., Folia Pharmacol. Jpn. 89, 291 (1987)
9. Kaneko, S., Haruno, A., Suzuki, N. et al., Folia Pharmacol. Jpn. 93, 55 (1989)
10. Nishizawa, O., Moriya, I., Nakamura, H. et al., J. Smooth Muscle Res. 22, 347 (1986)
11. Nishizawa, O., Sugaya, K., Kohama, T. et al., Neurourol. Urodyn. 8, 513 (1989)
12. Hattori, T., Yasuda, K., Diagnosis and Treatment of Neurogenic Bladder, p. 35, Igakushoin, Tokyo (1985)
13. Tsuchida, S., Nishizawa, O., Noto, H. et al., Acta Urol. Jpn. 36, 915 (1990)
14. Sjögren, G., Acta Pharmacol. Toxicol. 39, 167 (1976)
15. Kaneko, S., Kitazato, K., Yamazaki, Y. et al., Folia Pharmacol. Jpn. 95, 55 (1990)