Perinatal herpesvirus infections. Herpes simplex, varicella, and cytomegalovirus

Infectious Disease Clinics of North America

Volumn 11, Issue 1, 1997, Pages 27-54

  Scott, L L ^a   Hollier, L M ^a   Dias, K ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT; FAMCICLOVIR; GANCICLOVIR; VALACICLOVIR; VIRUS VACCINE;

CHICKENPOX; CYTOMEGALOVIRUS INFECTION; FEMALE; GENITAL HERPES; HERPES SIMPLEX; HERPES ZOSTER; HUMAN; NEWBORN INFECTION; PERINATAL INFECTION; PREGNANCY; REVIEW; VIRUS PNEUMONIA; VIRUS TRANSMISSION;

EID: 0030933488     PISSN: 08915520     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0891-5520(05)70340-8     Document Type: Review

References (145)

1. K. Adler-Storthz G.R. Dreesman R.H. Kaufman A prospective study of herpes simplex virus infection in a defined population in Houston, Texas Am J Obstet Gynecol 151 1985 582
2. A.L. Alkalay J.J. Pomerance D.L. Rimoin Fetal varicella syndrome J Pediatr 111 1987 320
3. American Academy of Pediatrics, American College of Obstetricians and Gynecologists Guidelines for Perinatal Care ed 3 1992 AAP Elk Grove Village, IL
4. American Academy of Pediatrics Report of the Committee on Infectious Diseases ed 21 1988 AAP Elk Grove Village, IL
5. American College of Obstetricians and Gynecologists Perinatal herpes simplex virus infections. ACOG Technical Bulletin 122 1988 ACOG Washington, DC
6. A. Andreou H. Basiakos I. Hatzikoumi Fetal varicella syndrome with manifestations limited to the eye Am J Perinatol 12 1995 347
7. Anonymous Varicella vaccine The Medical Letter 37 1995 55
8. Arvin A.M. P.A. Hensleigh C.G. Prober Failure of antepartum maternal cultures to predict the infant's risk of exposure to herpes simplex virus at delivery N Engl J Med 315 1986 796
9. A.M. Arvin C.G. Prober Herpes simplex virus infections Pediatr Infect Dis J 9 1990 765
10. R. Ashley A. Cent V. Maggs Inability of enzyme immtmoassays to discriminatebetween infections with herpes simplex virus types 1 and 2 Ann Intern Med 15 1991 520
11. L.M. Beauchamp G.F. Orr deMiranda P. Amino acid prodrugs of acyclovir Antiviral Chemistry & Chemotherapy 3 1992 157
12. J. Benedetti L. Corey R. Ashley Recurrence rates in genital herpes after symptomatic first-episode infection Ann Intern Med 121 1994 847
13. Blanchier H. J.M. Huraux C. Huraux-Rendu Genital herpes and pregnancy: Preventive measures Eur J Obstet Gynecol 53 1994 33
14. R.J. Bolognese S.L. Cosen D.A. Fuallo Herpes virus hominis type II infections in asymptomatic pregnant women Obstet Gynecol 48 1976 507
15. M.K. Breinig L.A. Kingsley J.A. Armstrong Epidemiology. of genital herpes in Pittsburgh: Serologic, sexual and racial correlates of apparent and inapparent herpes simplex infection J Infect Dis 162 1990 299
16. W.J. Britt C.A. Alford Cytomegalovirus Fields B.V. Knipe D.M. Howley P.M. Fields Virology ed 3 1996 Lippincott-Raven Philadelphia 2493
17. Brock B.V. S. Selke J. Benedetti Frequency of asymptomatic shedding of herpes simplex virus in women with genital herpes JAMA 263 1990 418
18. Z.A. Brown L.A. Vontver J. Benedetti Effects on infants of a first episode of genital herpes during pregnancy N Engl J Med 312 1987 1246
19. Z.A. Brown L.A. Vontver J. Benedetti Genital herpes in pregnancy: Risk factors associated with recurrences and asymptomatic viral shedding Am J Obstet Gynecol 153 1985 24
20. Z.A. Brown J. Benedetti R. Ashley Neonatal herpes simplex virus infections in relation to asymptomatic maternal infection at the time of labor N Engl J Med 324 1991 1247
21. Z.A. Brown D.A. Baker Acyclovir therapy during pregnancy Obstet Gynecol 73 1989 526
22. Y. Bryson M. Dellon D.I. Bernstein Risk of acquisition of genital herpes simplex virus type 2 in sex partners of persons with genital herpes: A prospective couple study J Infect Dis 167 1993 942
23. S.K. Burchett L. Corey K.M. Mohan Diminished interferon-γ, and lymphocyte proliferation in neonatal and postpartum primary herpes simplex virus infection J Infect Dis 165 1992 813
24. V. Catanzarite W. Danker Prenatal diagnosis of congenital cytomegalovirus infection: False negative amniocentesis at 20 weeks' gestation Prenatal Diagnosis 13 1993 1021
25. Centers for Disease Control Genital herpes infection, United States, 1966-1979 MMWR 31 1982 137
26. Centers for Disease Control Genital herpes simplex virus infections MMWR 42 1993 22
27. Centers for Disease Control Pregnancy outcomes following systemic prenatal acyclovir exposure: June 1, 1984-June 30, 1993 MMWR 42 1993 806
28. Centers for Disease Control and Prevention Recommendations of the immunization practices advisory committee: Varicella-zoster immune globulin for the prevention of chicken pox MMWR 33 1984 84
29. G.P.M. Clark P.M. Dobson A. Thickett Chicken pox pneumonia, its complications and management: A report of three cases, including the use of extracorporeal membrane oxygenation Anaesthesia 46 1991 376
30. R.W. Cone A.C. Hobson J. Palmer Extended duration of herpes simplex virus DNA in genital lesions detected by the polymerase chain reaction J Infect Dis 164 1991 757
31. R.W. Cone A.C. Hobson Z. Brown Frequent detection of genital herpes simplex virus DNA by polymerase chain reaction among pregnant women JAMA 272 1994 792
32. L. Corey The current trend in genital herpes: Progress in prevention Sex Transm Dis 21 2 suppl 1994 S38
33. L. Corey H.G. Adams Z.A. Brown Genital herpes simplex virus infections: Clinical manifestations, course and complications Ann Intern Med 98 1983 958
34. S.M. Cox F.G. Cunningham J. Luby Management of varicella pneumonia complicating pregnancy Am J Perinatol 7 1990 300
35. J.E. Cradock-Watson M.K.S. Rideholgh M.S. Bourne Specific immunoglobulin responses after varicella and herpes zoster Journal of Hygiene (London) 82 1979 319
36. G. Cuthbertson C.P. Weiner R.H. Giller Prenatal diagnosis of second-trimester congenital varicella syndrome by virus-specific immunoglobulin M J Pediatr 111 1987 592
37. DaSilva O. O. Hammerberg G.W. Chance Fetal varicella syndrome Pediatr Infect Dis J 9 1990 854
38. L.E. Davis G.V. Tweed T.D.Y. Chin Intrauterine diagnosis of cytomegalovirus infection: Viral recovery from amniocentesis fluid Am J Obstet Gynecol 109 1971 1217
39. G. Demmler Infectious Diseases Society of America and Centers for Disease Control. Summary of a workshop on surveillance for congenital cytomegalovirus disease Rev Infect Dis 13 1991 315
40. G.J. Demmler G.J. Buffone C.M. Schimbor Detection of cytomegalovirus in urine from newborns by using polymerase chain reaction DNA amplification J Infect Dis 158 1988 1177
41. C. Donner C. Liesnard J. Content Prenatal diagnosis of 52 pregnancies at risk for congenital cytomegalovirus infection Obstet Gynecol 82 1993 481
42. G. Enders Management of varicella-zoster contact and infection in pregnancy using a standardized varicella-zoster ELISA test Postgrad Med J 61 S4 1985 23
43. K.B. Fowler S. Stagno R. Pass The outcome of congenital cytomegalovirus infection in relation to maternal antibody status N Engl J Med 326 1992 663
44. Frederick I.B. R.J. White S.W. Braddock Excretion of varicella-herpes zoster virus in breast milk Am J Obstet Gynecol 154 1986 1116
45. B.J. Freij J.L. Sever Herpesvirus infections in pregnancy: Risks to embryo, fetus, and neonate Clin Perinatol 15 1988 203
46. L.M. Frenkel E.M. Garatty J.P. Shen Clinical reactivation of herpes simplex virus type 2 infection in seropositive women with no history of genital herpes Ann Intern Med 118 1993 414
47. L.M. Frenkel Z.A. Brown Y.J. Bryson Pharmacokinetics of acyclovir in the term human pregnancy and neonate Am J Obstet Gynecol 164 1991 569
48. Gibbs R.S. M.S. Amstey R.L. Sweet Management of genital herpes infection in pregnancy Obstet Gynecol 71 1988 779
49. Gilbert G.L. Varicella Infectious Disease in Pregnancy and the Newborn Infant 1991 Harwood Academic Chur, Switzerland 339
50. L.C. Gilstrap R.E. Bawdon S.W. Roberts The transfer of the nucleoside analog ganciclovir across the perfused human placenta Am J Obstet Gynecol 170 1994 967
51. E. Goff B. Griffith J. Booss Delayed amplification of cytomegalovirus infection in the placenta and maternal tissues during late gestation Am J Obstet Gynecol 156 1987 1265
52. I. Gold E. Azizi G. Eshel Neurogenic bladder due to herpes zoster infection in an infant Eur J Pediatr 148 1989 468
53. L.H. Goldberg R. Kaufman T.O. Kurtz Long-term suppression of recurrent genital herpes with acyclovir Arch Dermatol 129 1993 582
54. P.D. Griffiths C. Baboonian D. Rutter Congenital and maternal cytomegalovirus infection in a London population Br J Obstet Gynaecol 98 1991 135
55. Grose C. C. Weiner Prenatal diagnosis of congenital cytomegalovirus infection: Two decades later Am J Obstet Gynecol 163 1990 447
56. Z. Hagay G. Biran A. Ornoy Congenital cytomegalovirus infection: A longstanding problem still seeking a solution Am J Obstet Gynecol 174 1996 241
57. G.D.V. Hankins L.C. Gilstrap A. Patterson Acyclovir treatment of varicella pneumonia in pregnancy Crit Care Med 15 1987 336
58. K. Hanngren M. Grandien G. Granstrom Effect of zoster immunoglobulin for varicella prophylaxis in the newborn Scand J Infect Dis 17 1985 343
59. J.B. Hanshaw Cytomegalovirus infections Pediatr Rev 16 1995 43
60. R.E. Harris E.R. Rhoades Varicella pneumonia complicating pregnancy: Report of a case and review of the literature Obstet Gynecol 25 1965 734
61. C.J. Harrison W.J. Britt N.M. Chapman Reduced congenital cytomegalovirus (CMV) infection after maternal immunization with a guinea pig CMV glycoprotein before gestational primary CMV infection in the guinea pig model J Infect Dis 172 1995 1212
62. P.A. Hensleigh Undocumented history of maternal genital herpes followed by neonatal herpes meningitis J Perinatol 14 1994 216
63. K. Higa K. Dan H. Manage Varicella-zoster virus infections during pregnancy: Hypothesis concerning the mechanisms of congenital malformations Obstet Gynecol 69 1987 214
64. M.S. Hirsch M.N. Swartz Antiviral agents N Engl J Med 302 1980 949
65. R.A.V. Hodge Famciclovir and penciclovir: The mode of action of famciclovir including its conversion to penciclovir Antiviral Chemistry & Chemotherapy 4 1993 67
66. W.A. Hogge G.J. Buffone J.S. Hogge Prenatal diagnosis of cytomegalovirus (CMV) infection: A preliminary report Prenatal Diagnosis 13 1993 121
67. Hohlfeld P. Y. Vial C. Maillard-Brignon Cytomegalovirus fetal infection: Prenatal diagnosis Obstet Gynecol 78 1991 615
68. C. Hutto A. Arvin R. Jacobs Intrauterine herpes simplex virus infections J Pediatr 110 1987 97
69. Johnson L.G. L.R. Saldana Herpes simplex virus hepatitis in pregnancy J Reprod Med 39 1994 544
70. G.R. Kinghorn Epidemiology of genital herpes J Int Med Res 22 suppl 1 1994 14A
71. E. Klemola L. Kaarianinen Cytomegalovirus as a possible cause of a disease resembling infectious mononucleosis BMJ 2 1965 1099
72. D.M. Koelle J. Benedetti A. Langenberg Asymptomatic reactivation of herpes simplex virus in women after the first episode of genital herpes Arm Intern Med 116 1992 433
73. L.A. Koutsky C.E. Stevens K.K. Holmes Underdiagnosis of genital herpes by current clinical and viral isolation procedures N Engl J Med 326 1992 1533
74. S. Kroon Management Strategies in Herpes: Limiting the Continued Spread of Genital Herpes 1994 PPS Europe Ltd Worthing, United Kingdom 17 22
75. S. Kroon R. Whitley Management Strategies in Herpes: Can We Improve Management of Perinatal HSV Infections? 1995 PPS Europe Ltd Worthing
76. E.G. LaForet C.L. Lynch Multiple congenital defects following maternal varicella N Engl J Med 236 1947 534
77. S.R. Lambert D. Taylor A. Kriss Ocular manifestations of the congenital varicella syndrome Arch Ophthalmol 107 1989 52
78. M. Lamy K. Mulongo J. Gadisseux Prenatal diagnosis of fetal cytomegalovirus infection Am J Obstet Gynecol 166 1992 91
79. F. Lecurn R. Taurelle J.P. Bernard Varicella zoster virus infection during pregnancy: The limits of prenatal diagnosis Eur J Obstet Gynecol Reprod Biol 56 1994 67
80. L. Lynch F. Daffos D. Emanuel Prenatal diagnosis of fetal cytomegalovirus infection Am J Obstet Gynecol 165 1991 714
81. M. Maccato Herpes in pregnancy Clin Obstet Gynecol 36 1993 869
82. K.A. Martin A.K. Junker E.E. Thomas Occurrence of chickenpox during pregnancy in women seropositive for varicella-zoster virus J Infect Dis 170 1994 991
83. J.A. McGregor S. Mark G.P. Crawford Varicella zoster antibody testing in the care of pregnant women exposed to varicella Am J Obstet Gynecol 157 1987 281
84. P.B. Mead Proper methods of culturing herpes simplex virus J Reprod Med 31 suppl 1986 390
85. N.A. Menkhaus B. Lanphear C.C. Linnemann Airborne transmission of varicella-zoster virus in hospitals [letter] Lancet 336 1990 1315
86. G.J. Mertz D. Schmidt J.L. Jourden Frequency of acquisition of first-episode genital infection with herpes simplex virus from symptomatic and asymptomatic source contacts Sex Transm Dis 12 1985 33
87. G.J. Mertz J. Benedette R. Ashley Risk factors for the sexual transmission of genital herpes Ann Intern Med 116 1992 197
88. G.J. Mertz Epidemiology and diagnosis of genital herpes infections Current Opinion in Infectious Diseases 6 1993 17
89. Mertz G.J. Genital herpes simplex virus infections Med Clin North Am 74 1990 1433
90. G.J. Mertz Epidemiology of genital herpes infections Infect Dis Clin North Am 7 1993 825
91. G.J. Mertz R. Ashley R.L. Burke Double-blind, placebo-controlled trial of a herpes simplex virus type 2 glycoprotein vaccine in persons at high risk for genital herpes infection J Infect Dis 161 1990 653
92. E. Miller J.E. Cradock-Watson M.K.S. Ridehalgh Outcome of newborn babies given anti-varicella-zoster immunoglobulin after perinatal infection with varicella-zoster virus Lancet ii 1989 371
93. G.T. Nahass B.A. Goldstein W.Y. Zhu Comparison of Tzanck smear, viral culture, and DNA methods in detection of herpes simplex and varicella-zoster infection JAMA 2268 1992 2541
94. A.J. Nahmias Exogenous reinfection with herpes-simplex virus N Engl J Med 285 1971 236
95. Nahmias A.J. A.M. Visintine C.B. Reimer Herpes simplex virus infection of the fetus and newborn Krugman S. Gershon A.A. Infections of the Fetus and the Newborn Infant 1975 Alan R. Liss New York 63 77
96. A.J. Nahmias W.E. Josey Z.M. Naib Perinatal risk associated with maternal genital herpes simplex virus infection Am J Obstet Gynecol 110 1971 825
97. A.J. Nahmias B. Roizman Infection with herpes-simplex viruses 1 and 2 (third of three parts) N Engl J Med 289 1973 781
98. A.J. Nahmias C.A. Alford S.B. Korones Infection in the newborn with herpes virus hominis Adv Pediatr 17 1970 185
99. U. Nicolini A. Kustermarm B. Tassis Prenatal diagnosis of congenital human cytomegalovirus infection Prenatal Diagnosis 14 1994 903
100. R. Pass G. Myers Outcome of symptomatic congenital cytomegalovirus infection: Results of long-term longitudinal follow-up Pediatrics 66 1980 758
101. S.A. Plotkin T. Furukawa N. Zygraich Candidate cytomegalovirus strain for human vaccination Infect Immun 12 1975 521
102. A. Porath R. McNutt L. Smiley Effectiveness and cost benefit of a proposed live cytomegalovirus vaccine in the prevention of congenital disease Rev Infect Dis 12 1990 31
103. S.R. Preblud Varicella: Complications and costs Pediatrics 78 1986 728
104. Preblud S.R. S.L. Cochi W.A. Orenstein Varicella-zoster infection in pregnancy N Engl J Med 315 1986 1416
105. Pretorius D.H. I. Hayward K.L. Jones Sonographic evaluation of pregnancies with maternal varicella infection J Ultrasound Med 11 1992 459
106. C.G. Prober L. Corey Z.A. Brown The management of pregnancies complicated by genital infections with herpes simplex virus Clin Infect Dis 15 1992 1031
107. Prober C.G. Herpetic vaginitis in 1993 Clin Obstet Gynecol 36 1993 177
108. C.G. Prober P.A. Hensleigh F.D. Boucher Use of routine viral cultures at delivery to identify neonates exposed to herpes simplex virus N Engl J Med 318 1988 887
109. C.G. Prober W.M. Sullendar L.L. Yasukawa Low risk of herpes simplex virus infections in neonates exposed to the virus at the time of vaginal delivery to mothers with recurrent genital herpes simplex virus infections N Engl J Med 316 1987 240
110. C.G. Prober A.A. Gershon C. Grose Consensus: Varicella-zoster infections in pregnancy and the perinatal period Pediatr Infect Dis J 9 1990 865
111. E. Puchhammer-Stöckl C. Kunz C. Wagner Detection of varicella virus (VZV) DNA in fetal tissue by polymerase chain reaction J Perinatol Med 22 1994 65
112. S.M. Ramin L.C. Gilstrap Varicella zoster in pregnancy Pastorek J.G. Obstetric and Gynecologic Infectious Disease 1994 Raven Press New York 343
113. R.C. Randel D.B. Kearns M.P. Nespeca Vocal cord and paralysis as a presentation of intrauterine infection with varicella-zoster virus Pediatrics 97 1996 127
114. A.G. Randolph A.E. Washington C.G. Prober Caesarean delivery for women presenting with genital herpes lesions. Efficacy, risks, and costs JAMA 270 1993 77
115. D.W. Reynolds S. Stagno K.G. Stubbs Inapparent congenital cytomegalovirus infection with elevated cord IgM levels: Causal relationship with auditory and mental deficiency N Engl J Med 209 1974 291
116. S.W. Roberts S.M. Cox J. Dax Genital herpes during pregnancy: No lesions, no caesarean Obstet Gynecol 85 1995 261
117. D.J. Rouse M. Gardner S.J. Allen Management of the presumed susceptible varicella (chickenpox)-exposed gravida: A cost effectiveness/cost-benefit analysis Obstet Gynecol 87 1996 932
118. A. Scharf O. Scherr G. Enders Virus detection in the fetal tissue of a premature delivery with a congenital varicella syndrome: A case report J Perinat Med 18 1990 317
119. L.L. Scott P.J. Sanchex G.R. Jackson Acyclovir suppression to prevent cesarean delivery after first-episode genital herpes Obstet Gynecol 87 1996 69
120. Scott LL, Wendel G, Frequency of herpes simplex virus (HSV) recovery among women with cesarean sections for genital herpes [abstract]. Presented at the 42nd Annual Clinical Meeting of the American College of Obstetricians and Gynecologists, Orlando, FL, 1994.
121. Sever J.A. L.R. White Intrauterine vital infections Annu Rev Med 19 1969 471
122. M. Siegel H.T. Fuerst N.S. Peress Comparative fetal mortality in maternal virus disease N Engl J Med 274 1966 768
123. R.A. Smego M.O. Asperilla Use of acyclovir for varicella pneumonia during pregnancy Obstet Gynecol 78 1991 1112
124. S. Stagno G. Cloud R. Pass Factors associated with primary cytomegalovirus infection during pregnancy J Med Virol 13 1984 347
125. S. Stagno R. Pass G. Cloud Primary cytomegalovirus infection in pregnancy: Incidence, transmission to fetus, and clinical outcome JAMA 256 1986 1904
126. S. Stagno R. Whitley Herpesvirus infections of pregnancy. Part I. Cytomegalovirus and Epstein-Barr virus infections N Engl J Med 313 1985 1270
127. S. Stagno M. Tinker C. Elrod Immunoglobulin M antibodies detected by enzyme-linked immunosorbent assay and radioimmunoassay in the diagnosis of cytomegalovirus infections in pregnant women and newborn infants J Clin Microbiol 21 1985 930
128. Stanberry L.R. The concept of immune-based therapies in chronic viral infections J Acquir Immune Defic Syndr 7 suppl1 1994 S1
129. D.W. Steyn H.J. Odendaal Fetal resuscitation in a patient with varicella pneumonia and preterm labor Int J Gynecol Obstet 30 1989 171
130. K.M. Stone C.A. Brooks M.E. Guinan National surveillance for neonatal herpes simplex virus infections Sex Transm Dis 16 1989 152
131. S.E. Straus M. Seidlen H. Takeff Effect of oral acyclovir treatment on symptomatic and asymptomatic virus shedding in recurrent genital herpes Sex Transm Dis 16 1989 107
132. S.E. Straus L. Corey R.L. Burke Placebo-controlled trial of vaccination with recombinant glycoprotein D of herpes simplex virus type 2 for immunotherapy of genital herpes Lancet 343 1994 1460
133. B. Stray-Pedersen Acyclovir in late pregnancy to prevent neonatal herpes simplex Lancet 336 1990 756
134. B. Stray-Pedersen Genital herpes in pregnant women in Oslo, Norway [abstract]. In Programs and Abstracts of the First European Congress for Infectious Diseases in Obstetrics and Gynecology 1992 Taormina-Giardini Naxos Italy
135. M. Stronati M.G. Revello R.M. Cerbo Ganciclovir therapy of congenital human cytomegalovirus hepatitis Acta Paediatr 84 1995 340
136. Sullivan-Bolyai J. H.F. Hull C. Wilson Neonatal herpes simplex infection in King County, Washington: Increasing incidence and epidemiological correlates JAMA 50 1983 3059
137. R.L. Sweet R.S. Gibbs Herpes simplex virus infection Infectious Diseases of the Female Genital Tract ed 2 1990 Williams & Wilkins Baltimore 144 157
138. Vontver L.A. D.E. Hickock Z. Brown Recurrent genital herpes simplex virusinfection in pregnancy: Infant outcome and frequency of asymptomatic recurrences Am J Obstet Gynecol 143 1982 75
139. S. Weller M.R. Blum M. Doucette Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single- and multiple-dose administration to normal volunteers Clin Pharmacol Ther 54 1993 595
140. K.J. Whaley R.A. Barratt L. Zeitlin Nonoxynol-9 protects mice against vaginal transmission of genital herpes infections J Infect Dis 168 1993 1009
141. Whaley K.J. L. Zietlin R.A. Barratt Passive immunization of the vagina protects mice against vaginal transmission of genital herpes infection J Infect Dis 169 1994 647
142. R.J. Whitley A.J. Nahmias A.M. Visintine The natural history of herpes simplex virus infection of mother and newborn Pediatrics 66 1980 489
143. R.J. Whitley L. Corey A. Arvin Changing presentation of herpes simplex virus infection in neonates J Infect Dis 158 1988 109
144. R. Whitley A. Arvin C. Prober A controlled trial comparing vidarabine with acyclovir in neonatal herpes simplex virus infection N Engl J Med 324 1991 444
145. M.D. Yow Congenital cytomegalovirus disease: A now problem J Infect Dis 159 1989 163