Thiotepa and etoposide treatment of recurrent malignant gliomas: Phase I study

Cancer Chemotherapy and Pharmacology

Volumn 40, Issue 1, 1997, Pages 72-74

  Balmaceda, Casilda ^a   Fetell, Michael R ^a   Hesdorffer, Charles ^b  

^a New York Presbyterian Hospital Columbia University Medical Center   (United States)

^b NewYork Presbyterian Hospital   (United States)

Author keywords

Chemotherapy; Etoposide; Malignant glioma; Thiotepa

Indexed keywords

CARMUSTINE; ETOPOSIDE; THIOTEPA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; GLIOBLASTOMA; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LEUKOPENIA; PHASE 1 CLINICAL TRIAL; PNEUMOCYSTIS PNEUMONIA; PRIORITY JOURNAL; RECURRENT CANCER;

ADOLESCENT; ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRAIN NEOPLASMS; ETOPOSIDE; FEMALE; GLIOMA; HUMANS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; THIOTEPA;

EID: 0030933487     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050628     Document Type: Article

References (21)

1. Ahmed T, Feldman E, Helson L, Biguzzi S, Szalyga A (1990) Phase I-II trial of high-dose thiotepa (HDT) with autologous hone marrow transplantation (ABMT) and localized radiotherapy (RT) for patients (pts) with astrocytoma grade III-IV (abstract). Proc Am Assoc Cancer Res 31:172
2. Cavalli F (1982) VP-16-213 (etoposide). A critical review of its activity. Cancer Chemother Pharmacol 7:81-85
3. D'Incalci M, Farina P, Sessa C, Mangioni C, Conter V, et al. (1982) Pharmacokinetics of VP-16-213 given by different administration methods. Cancer Chemother Pharmacol 7:141-145
4. Dwyer P, LaCreta F, Ensgstrom P, Peter R, Tartaglia L (1991) Phase I/pharmacokinetic evaluation of thiotepa. Cancer Res 51:3171-3176
5. Edwards M, Levin V, Seager M, Pischer T, Wilson C (1979) Phase II evaluation of thiotepa for treatment of central nervous system tumors. Cancer Treat Rep 63:1419-1421
6. Fine H, Dear K, Loeffler J, et al. (1990) Meta-analysis of adjuvant chemotherapy for malignant gliomas in adults. Proc Am Soc Clin Oncol 10:367-372
7. Finlay J, August C, Packer R, et al. (1990) High-dose multi-agent chemotherapy followed by bone marrow "rescue" for malignant astrocytomas of childhood and adolescence. J Neurooncol 9:239-248
8. Friedman H, Colvin O, Ludeman S, Schold S, Boyd V, Muhlbaier L (1986) Experimental chemotherapy of human medulloblastoma with classical alkylators. Cancer Res 46:2827-2833
9. Friedman H, Colvin O, Skapek S, Ludeman S, Elion G, Schold S (1988) Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenographs with bifunctional alkylating agents. Cancer Res:4189-4195
10. Hardt R (1981) One day VATH therapy for advanced breast cancer refractory to prior chemotherapy. Cancer 48:1522-1527
11. Heideman R, Cole D, Balis F, Sato J, Reaman G (1989) Phase I and pharmacokinetic evaluation of thiotepa in the cerebrospinal fluid of plasma of pediatric patients: evidence for dose-dependent plasma clearance of thiotepa. Cancer Res 49:736-741
12. Heideman R, Packer R, Reaman G, Allen J, Lange B (1993) A phase II evaluation of thiotepa in pediatric central nervous system malignancies. Cancer 72:272-275
13. Kornblith P, Walker M (1988) Chemotherapy for malignant gliomas. J Neurosurg 68:1-17
14. Lesser G, Grossman S (1993) The chemotherapy of adult primary brain tumors. Cancer Treat Rev 19:261-281
15. Long J, Leff R, Daly M (1989) Phase II trial of high-dose etoposide and autologous hone marrow transplantation for treatment of progressive glioma. Proc Am Soc Clin Oncol 8:92
16. Masters J (1986) Intravesical chemotherapy Lancet 1:740
17. Ng S, Waxman D (1991) N,N′,N″-triethylenethiophosphoramide (thio-TEPA) oxygenation by constitutive hepatic P450 enzymes and modulation of drug metabolism and clearance in vivo by P450-inducing agents. Cancer Res 51:2340-2345
18. Stewart D, Richard M, Hugenholtz H, Dennery J, Belanger R (1984) Penetration of VP-16 (etoposide) into human intracerebral and extracerebral tumors. J Neurooncol 2:133-139
19. Tirelli U, D'Incalci M, Canetta R, Tumolo S, Franchin G (1984) Etoposide (VP-16-213) in malignant brain tumors: a phase II study. J Clin Oncol 2:432-437
20. Van Maanen JMS, Retel J, De Vries J, Pinedo HA (1988) Mechanism of action of antitumor drug etoposide: a review. J Natl Cancer Inst 80:1526-1533
21. Wolf S, Phillips G, Fay J, Giannone L, LeMaistre C (1987) Highdose chemotherapy with autologous marrow transplantation for gliomas of the central nervous system. In: Dicke KA, Spitzer G, Jagannath S (eds) Autologous bone marrow transplantation. Proceddings Third International Symposium. The University of Texas M.D. Anderson Cancer Center, Houston 1987. pp 557-563